[Micronuclear and antitumor activities of two newly synthesized pyrimidine derivatives].

Micronuclear and antitumor activities of two newly synthesized iodides of pyrazolo[1,5a]pyrimidines were investigated using mice model. It has been shown that both compounds are slightly toxic and have no antitumor activity in mice with Ehrlich's ascites carcinoma. Only one of them has weak micronuclear activity. Both compounds increase substantially micronuclear as well as antitumor activities of cyclophosphamide.

[Kinetics of the cell proliferation of murine mammary adenocarcinoma under the influence of methylcobalamine]. / Kinetika proliferatsii kletok adenokartsinomy molochnoi zhelezy myshei pod vliianiem metilkobalamina.

The mechanism of the stimulant effect of methylcobalamine on the growth of mouse adenocarcinoma 755 was studied. More rapid growth of adenocarcinoma 755 under the cobalamine coentzyme effect is consequent on an increased proliferative pool with the stable parameters of the mitotic cycle and minimal death of tumour cells. Apparently, inhibition of DNA synthesis in the greater S-phase cell subpopulation potentiated the antitumour effect of methotrexate combined with methylcobalamine.