Synthesis and biological studies of pyrimidine derivatives targeting metabolic enzymes.

Novel synthesized pyrimidine derivatives were investigated against carbonic anhydrase isoenzymes I and II (hCA I and II), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), α-glycosidase, and aldose reductase (AR) enzymes associated with some common diseases such as epilepsy, glaucoma, Alzheimer's disease, diabetes, and neuropathy. When the results were examined, novel synthesized pyrimidine derivatives were found to have effective inhibition abilities toward the metabolic enzymes. IC50 values and Ki values were calculated for each pyrimidine derivative and compared to positive controls. The synthesized novel pyrimidine derivatives exhibited Ki values in the range of 39.16 ± 7.70-144.62 ± 26.98 nM against hCA I, 18.21 ± 3.66-136.35 ± 21.48 nM toward hCA II, which is associated with different pathological and physiological processes, 33.15 ± 4.85-52.98 ± 19.86 nM on AChE, and 31.96 ± 8.24-69.57 ± 21.27 nM on BChE. Also, Ki values were determined in the range of 17.37 ± 1.11-253.88 ± 39.91 nM against α-glycosidase and 648.82 ± 53.74-1902.58 ± 98.90 nM toward AR enzymes. Within the scope of the study, the inhibition types of the novel synthesized pyrimidine derivatives were evaluated.

The impact of quinoa flour on some properties of ayran.

In this study, some physical, chemical, microbiological, and sensory properties of ayran produced from quinoa flour addition at different ratios (0.1, 0.2, 0.3, and 0.4%, w/v) were investigated. The effect of quinoa addition and storage time on pH, titration acidity, serum separation, L values and microorganism counts were statistically significant (p < .05). The counts of Streptococcus salivarus subsp. thermophilus and Lactobacillus delbruecki subps. bulgaricus had a wide range between 7.13 and 7.52 log CFU/mL and 3.62 and 3.98 log CFU/mlL At the end of the storage, the general appreciation score of the sample containing 0.2% quinoa flour was found to be higher than the other samples.

NAM Therapy-Evidence-Based Results.

Many orthodontists working on patients with cleft lip and palate (CLP) have shown great enthusiasm for presurgical infant orthopedics (PSIO) to improve surgical outcomes with minimal intervention. Even though every clinician aims to use the best treatment modality for their patients, PSIO effects can be confounded by surgical type and timing of the primary repair, as is discussed in many studies. In such cases, one should be cautious when evaluating the particular outcomes for patients with CLP since it is difficult to differentiate the sole effect of an individual surgical or orthodontic intervention. As with any treatment methodology, nasoalveolar molding (NAM) has both benefits and limitations. Commonly cited concerns with NAM, and PSIO in general, include increased cost, increased burden of care, and a negative impact on maxillary growth. However, NAM cannot be deemed as having apparent long-term negative or positive effects on skeletal or soft tissue facial growth, based on previous studies. A review of the literature suggests that NAM does not alter skeletal facial growth when compared with the samples that did not receive PSIO. Nevertheless, the published studies on NAM show evidence of benefits to the patient, caregivers, the surgeon, and society. These benefits include documented reduction in severity of the cleft deformity prior to surgery and as a consequence improved surgical outcomes, reduced burden of care on the care givers, reduction in the need for revision surgery, and consequent reduced overall cost of care to the patient and society.

Relationship between internet addiction and alexithymia among university students.

PURPOSE: Epidemiological studies concerning internet addiction found that 50% of internet addicts also have other kinds of psychiatric disorders. This study aims to examine the relationship between alexithymia and internet addiction levels among Turgut Özal University students in Ankara, Turkey. METHOD: University students (1,107 students; 452 students from 12 associate degree programs and 655 students from 10 undergraduate programs) participated in the study. The researchers used the personal information form, the Toronto Alexithymia Scale and the Internet Addiction Scale. The approval for the current study was received from the Turgut Özal University Medical Faculty Clinical Studies Ethics Committee. RESULTS: The number of the alexithymic students was 12.5% whereas the number of the students who were internet addicts was 13.5%. The internet addiction scores were higher among alexithymic individuals than the non-alexithymic (p.

Minimally Invasive Plate Osteosynthesis in Open Pediatric Tibial Fractures.

OBJECTIVES: The aim of this study is to investigate the effectiveness and reliability of limited-contact locking plates in minimally invasive percutaneous osteosynthesis (MIPO) of the lateral tibia. DESIGN: A retrospective study. PATIENTS AND METHODS: The retrospective study included 14 patients who were operatively treated with an MIPO technique due to open tibial fractures between 2006 and 2012. The patients were 11 males and 3 females with a mean age of 13.2 (range, 9 to 16) years. The patients were followed up for a mean period of 2.4 (range, 1 to 5) years. The mechanism of the injuries included a motor vehicle accident (n=11), a shotgun injury (n=2), and a fall from height (n=1). According to the Gustilo-Anderson classification, 10 patients had type I (72%), 2 had type II (14%), and 2 had type III (14%) open fractures. RESULTS: The mean time to radiologic union was 18 (range, 11 to 32) weeks. No infection was detected that would require implant removal. No complications such as early epiphyseal closure, angulation, or limb-length inequality were observed. CONCLUSIONS: Limited-contact locking plates in MIPO of the lateral tibia is an effective alternative method in the treatment of open pediatric tibial fractures. LEVEL OF EVIDENCE: Level IV-therapeutic.

Use of corn oil in the production of Turkish white cheese.

The use of corn oil in white cheese production instead of milk fat was investigated and its effects on the quality parameters of cheese were studied. It was demonstrated that the use of corn oil significantly affected the levels of dry matter, fat in dry matter, protein, salt in dry matter and titratable acidity and pH value of samples (p < 0.05). The water-soluble nitrogen based ripening indices of cheeses increased throughout the ripening period. However, there were not large quantitative differences among the peptide profiles of all the cheese samples. The polyunsaturated fatty acids (PUFA), the polyunsaturated to saturated fatty acid ratios (PUFA/SFA) and total cis fatty acid contents were found to be higher whilst the saturated fatty acid and trans fatty acid content were found to be lower than those of the control cheese (p < 0.05). It was found that the use of corn oil instead of milk fat in cheese production decreased the cholesterol content of the cheese samples (p < 0.05). The sensory scores of corn oil cheese were almost similar to the control cheese. The results indicated that corn oil utilization in cheese production has commercial potential in overcoming the defects related to fat reduction.

Cephalometric investigation of first cervical vertebrae morphology and hyoid position in young adults with different sagittal skeletal patterns.

The aim of this retrospective study was to examine hyoid bone position and C1 (atlas) morphology in males and females and analyze these parameters with respect to different sagittal skeletal patterns via cephalometry, with the goal of identifying cephalometric norms. Lateral cephalometric radiographs from 120 individuals (average age: 21.1 ± 2.9 years) were classified according to their ANB angle (Class I, II, or III) and used to assess 14 parameters. Class I and II patients showed significant differences in Hy-NSL, Hy-PD, Hy-CVT, Lum, and a-p measurements. These parameters were consistently larger in males than in females. Intergroup comparisons among males showed significant differences in the SNA, ANB, Hy-CVT, X, and Z measurements. The hyoid was positioned more inferiorly and anteriorly and was more prominent in males than in females in all groups. Among participants exhibiting a Class I skeletal pattern, C1 was also larger in the anterior-posterior direction in males than in females. In the sagittal plane, the hyoid was positioned similarly in males with either Class I or III skeletal patterns but was positioned posteriorly in males with a Class II skeletal pattern. In addition, the vertical position of C1 varied with sagittal skeletal pattern in males.

Prevalence of refraction errors and color blindness in heavy vehicle drivers.

AIM: To investigate the frequency of eye disorders in heavy vehicle drivers. METHODS: A cross-sectional type study was conducted between November 2004 and September 2006 in 200 driver and 200 non-driver persons. A complete ophthalmologic examination was performed, including visual acuity, and dilated examination of the posterior segment. We used the auto refractometer for determining refractive errors. RESULTS: According to eye examination results, the prevalence of the refractive error was 21.5% and 31.3% in study and control groups respectively (P<0.05). The most common type of refraction error in the study group was myopic astigmatism (8.3%) while in the control group simple myopia (12.8%). Prevalence of dyschromatopsia in the rivers, control group and total group was 2.2%, 2.8% and 2.6% respectively. CONCLUSION: A considerably high number of drivers are in lack of optimal visual acuity. Refraction errors in drivers may impair the traffic security.

Prevalence of refraction errors and color blindness in heavy vehicle drivers / 国际眼科杂志(Guoji Yanke Zazhi)

AIM:To investigate the frequency of eye disorders in heavy vehicle drivers.METHODS:A cross-sectional type study was conducted between November 2004 and September 2006 in 200 drivers and 200 non-driver persons.A complete ophthalmologic examination was performed,including visual acuity and dilated examination of the posterior segment.We used the auto refractometer for determining refractive errors.RESULTS:According to eye examination results,the prevalence of the refractive errors was 21.5% and 31.3% in study and control groups respectively (P<0.05).The most common type of refraction errors in the study group was myopic astigmatism (8.3%) while in the control group simple myopia(12.8%).Prevalence of dyschromatopsia in the drivers,control group and total group was 2.2%,2 8% and 2.6% respectively.CONCLUSION:A considerably high number of drivers are in lack of optimal visual acuity.Refraction errors in drivers may impair the traffic security.

Longitudinal profile changes in an Anatolian Turkish population.

The goal of this study was to assess longitudinal changes in the facial soft tissue profile in relation to age and gender in young Anatolian Turkish subjects. A total of 30 subjects (15 females and 15 males) with an Angle Class I occlusal relationship and normal antero-posterior (ANB, 2-4 degrees) skeletal relationships were selected from the archive of Dicle University. All subjects were of Anatolian Turkish heritage, and none had any apparent facial disharmony or had undergone orthodontic therapy. Lateral cephalometric radiographs taken at T1 (mean age 8.8 years), T2 (mean age 13.8 years), and T3 (mean age 17.8 years) were separately investigated. Non-gender-specific research was also carried out at the same time periods. In total, 24 measurements were analysed longitudinally. Differences between the genders were determined using independent t-tests. Repeated measures analysis of variance tests were used to evaluate repeated measurements, and paired sample t-tests to compare inside effects between the genders. Significant increases (P < 0.05) were found with age for both females and males. Generally, the increases were greater in males than in females. Nasal prominence increased more than chin prominence, resulting in a tendency to have convex profiles.

Mixed-dentition analysis in a Turkish population.

OBJECTIVE: To study the reliability of the Tanaka-Johnston mixed-dentition analysis in Turkish individuals and develop a new population-adjusted regression equation for predicting the size of unerupted canines and premolars. The new regression equations were tested to establish their validity in Turkish children. METHODS: The mesiodistal dimensions of teeth on study casts of 12- to 14-year-old Turkish children were measured. The actual tooth measurements were then compared with predicted values using the Tanaka-Johnston equation. Subsequently, the new regression equations were tested in a group of 50 individuals to determine their validity. RESULTS: The Tanaka-Johnston regression equations overestimated the actual mesiodistal widths of permanent canines and premolars. With the new regression equations, no statistically significant differences were observed between actual and predicted widths. CONCLUSION: The Tanaka-Johnston prediction method is not accurate when applied to a Turkish population. The new equations are reliable for predicting the width of unerupted canines and premolars in Turkish individuals.

One-year follow-up of the effect of fixed orthodontic treatment on colonization by oral Candida.

The aim of this study was to assess quantitative and qualitative alterations in the carrier rate of Candida spp. in south-eastern Turkey among adolescents, and to investigate the effect of fixed orthodontic appliances on the Candida count in a 1-year follow-up study. In the first phase of the study, the oral Candida carriage rate of 72 patients was evaluated. Samples were collected from the dorsal surface of the tongue, the mid-palate and saliva. In the second phase of the study, 42 patients who were determined to be carriers of oral Candida were treated with fixed orthodontic appliances, and from these patients a second set of samples were collected from the saliva and the orthodontic brace surfaces of eight teeth adjacent to the enamel surfaces. The saliva samples were collected before and during orthodontic treatment at 1st, 6th and 12th month, and samples from the braces were collected during the 1st, 6th and 12th month of treatment. Forty-two of the 72 patients (58.5%) were oral Candida carriers. The distribution of Candida spp. in these patients was as follows: (i) Candida albicans was identified in 31 patients (73.8%), (ii) C. tropicalis, C. krusei and C. kefyr were found in three patients each (7.14%) and (iii) C. parapsilosis occurred in two patients (4.76%). During orthodontic treatment, the micro-organism count increased both in the saliva and on tooth surfaces. The results indicate that the prevalence of oral Candida spp. is high in young adults in south-eastern Turkey and that the Candida counts increase when braces are involved.

Comparison of facial proportions and anthropometric norms among Turkish young adults with different face types.

BACKGROUND: This study aimed to determine the prevalence of three different face types among Turkish young adults based on facial indices, to assess and compare the vertical and horizontal dimensions for each type, and to establish anthropometric norms for Turkish adults. METHODS: A total of 173 healthy young adults (83 females and 90 males) 17 to 25 years of age were examined. Using anthropometric landmarks, 8 horizontal and 10 vertical direct measurements were made with a millimetric compass. RESULTS: Using facial indices, 59 of the 173 subjects were classified as euryprosopic, 49 as mesoprosopic, and 65 as leptoproposic. In the total evaluation of both groups, all the parameters were higher in the males except forehead heights 1 and 2. A comparison of face types in females and males separately showed no significant differences between the parameters. CONCLUSIONS: The data presented in this study may help plastic surgeons and orthodontists objectively determine the relationships between facial structures for different face types. Additionally, the facial anthropometric norms derived from this study may be useful in the treatment of Turkish patients.

Effects on the sagittal pharyngeal dimensions of protraction and rapid palatal expansion in Class III malocclusion subjects.

This study examined the effects of rapid palatal expansion (RPE) and maxillary protraction headgear therapy in 18 patients with a skeletal Class III malocclusion (11 girls and seven boys; mean age 10.9 years) on upper airway dimensions compared with an untreated control group (nine girls and eight boys; mean age 10.9 years). Pre- and post-treatment cephalometric radiographs were traced and analysed at similar time intervals. The average treatment time was 6.94 +/- 0.56 months. Wilcoxon's test was used for intragroup comparisons and the Mann-Whitney U-test for intergroup comparisons. A significant increase occurred in the maxillary forward position. Mandibular forward movement and downward and backward rotation were inhibited. In addition, the upper incisors were proclined (P < 0.001), and the lower incisors were significantly retroclined (P < 0.05). When the treatment and control groups were compared, the upper airway linear measurements (pns-ad1, pns-ad2, APW-PPW, APW'-PPW') and the nasopharyngeal area had increased in the treatment group. These results demonstrated that maxillary expansion together with protraction of the maxilla improved naso- and oropharyngeal airway dimensions in the short term.

Longitudinal changes in dental arches from mixed to permanent dentition in a Turkish population.

INTRODUCTION: Orthodontists can benefit from understanding occlusal changes during every stage of human development. The growth and development period is influenced by environmental factors, nutrition, and ethnic variations; systemic health and individual variations can also occur. Our aim in this study was to investigate the longitudinal changes in dental arch dimensions during the transition from mixed dentition (T1) to permanent dentition (T2) in children living in Turkey. METHODS: Sixty-five patients (36 girls, 29 boys) with complete records from the mixed dentition to the early permanent dentition stages were included in this study (total, 130 dental casts). All casts (T1 and T2) had been prepared in centric relation by wax bites, and 14 parameters were measured on these casts. RESULTS: The initial parameters in this Turkish population showed sexual dimorphism; however, during the observation period (T2-T1), there was no sexual dimorphism in arch dimension changes. There were significant changes in arch width parameters (especially in girls), overjet, and overbite in Turkish children between the midmixed and the permanent dentitions. CONCLUSIONS: These results should be useful in planning orthodontic treatment for patients in the mixed and early permanent dentition.

Effects of estrogen deficiency on tooth movement after force application: an experimental study in ovariectomized rats.

OBJECTIVE: The aim of this study was to investigate the effects of estrogen deficiency on tooth movement in ovariectomized rats. MATERIAL AND METHODS: Forty-two adult female Sprague-Dawley rats were assigned at random to one of the following groups: test group (n=20), ovariectomized rats (or estrogen-deficient rats); control group (n=22), non-ovariectomized rats. Two months after ovariectomy, expansion springs exerting 10 g of force were inserted between the upper central incisors in both groups. The amount of movement was measured daily until tooth movement began and then at intervals of 3 days. The rats were sacrificed 18 days after applying the expansion spring and histomorphometric analysis was performed along the left upper central incisor root towards the apex of the alveolar bone. RESULTS: The amount and speed of movement was observed to be greater in ovariectomized rats. On histomorphometric analysis, osteoblast and osteocyte counts on the pressure side were higher in the non-ovariectomized group than in the ovariectomized group (p<0.001). In contrast, the osteoclast count was significantly higher (p<0.01) in the ovariectomized group than in the non-ovariectomized group. The osteoblast and osteocyte counts were significantly higher (p<0.001) on tension side in the non-ovariectomized group than in the ovariectomized group. CONCLUSION: Estrogen deficiency increased orthodontic tooth movements but counts of osteoblasts, which are responsible for new bone formation, were lower in regions of tension and of pressure.

The prevalence of diabetes and impaired glucose tolerance in Sivas, Central Anatolia, Turkey.

OBJECTIVE: The aim of this study was to determine type 2 diabetes, impaired glucose tolerance (IGT), and impaired fasting glucose (IFG) prevalence in Sivas, Turkey. RESEARCH DESIGN AND METHODS: This cross-sectional study was conducted in the city center of Sivas. The study population of 771 subjects was selected by the cluster sampling method from 115,998 individuals aged > or =30 years. Participants with fasting venous plasma glucose concentrations <100 mg/dl were classified as "normal." Diabetes was diagnosed in participants if they had fasting blood glucose levels > or =126 mg/dl. An oral glucose tolerance test (OGTT) was performed in subjects with fasting blood glucose levels > or =100 mg/dl and <126 mg/dl. RESULTS: According to the fasting blood glucose levels of the 771 subjects, 44 (5.7%) had diabetes. OGTTs were performed in 80 (10.4%) subjects. According to OGTT results, there were 5 subjects with diabetes, 20 subjects with IGT (2.6%), and 55 subjects with IFG (7.1%). The combined prevalence of IFG and IGT was 9.7%. After OGTT, the total number of diabetic subjects was determined to be 49 (6.4%). Twenty-four (3.1%) of the subjects had a previous diagnosis of diabetes. Multivariate analyses showed that age, sex, hypertension, cigarette smoking, obesity, and family history of diabetes were risk factors for type 2 diabetes (P < 0.05). CONCLUSIONS: Diabetes incidence increases with changes in dietary habits and lifestyle. Education is particularly important for public health, as the community may then have required knowledge about the disease and its risk factors.

Correction of a severe Class III malocclusion.

The success of early orthopedic treatment in patients with Class III anomalies depends on facial skeletal development and type of treatment. This case report describes the treatment of a 12.6-year-old girl who had a severe Class III malocclusion with a 6-mm anterior crossbite, a deep overbite, a narrow maxilla, and unerupted maxillary canines. The treatment plan included rapid palatal expansion to expand the maxilla, reverse headgear to correct the maxillary retrognathia, a removable anterior inclined bite plane to correct the anterior crossbite and the deep overbite, and fixed edgewise appliances to align the teeth. One canine was brought into alignment, but the other was placed in occlusion in its transposed position. Ideal overjet and overbite relationships were established, and the final esthetic result was pleasing.