[The action of sodium oxybutyrate and emoxypin on the functional state of the adrenaline-damaged myocardium in an experiment]. / Deistvie natriia oksibutirata i émoksipina na funktsionnal'noe sostoianie povrezhdennogo adrenalinom miokarda v éksperimente.

The effect of agents possessing antihypoxic and antioxidant activity, namely sodium oxybutyrate and emoxypin, on the functional state of the heart muscle was studied in experiments on dogs with epinephrine necroses of the myocardium. A marked cardioprotective effect was produced by sodium oxybutyrate infused intravenously (200 mg/kg) either 10 min or 2 hrs after myocardial damage had been modelled and by emoxypin (4 mg/kg; 0.4 mg/kg) infused intravenously 30 min after the damage.

[The current possibilities for the pharmacological regulation of myocardial metabolism in experimental catecholamine-induced necroses]. / Sovremennye vozmozhnosti farmakologicheskoi reguliatsii metabolizma miokarda pri éksperimental'nykh katekholaminovykh nekrozakh.

Catecholamine-induced myocardial necroses have their own peculiarities but the disorders in myocardial metabolism occurring in them do not differ in quality from those encountered in necroses caused by occlusion of the coronaries. Pharmacological regulation of the metabolism of a myocardium damaged by catecholamines may be accomplished by the same drugs which are used in necroses caused by coronary occlusion, but agents with antihypoxic and antioxidant activity are preferable.