[Effects of immunologic markers on prognosis in acute lymphoblastic leukemia in young children]. / Vliianie immunologicheskikh markerov na prognoz ostrogo limfoblastnogo leikoza u detei rannego vozrasta.

Altogether 77 children aged up to 3 years with acute lymphoblastic leukemia (ALL) were examined for the immunological phenotype of blast cells. L1, L1/L2, L2/L1, L2 variants of ALL and the undifferentiated one were established in accordance with criteria of the FAB classification. T1, zero and Ia immunosubvariants were recorded most frequently. Mature cell T2 and pre-B variants (3 and 2 cases, respectively) were rare; B-cellular acute lymphoblastic leukemia was lacking; the "common" subvariant was revealed in 28 patients. The patients' age produced the highest effect on the prognosis: the significantly least disease standing and remissions were noted in a group of children under 2 years as compared to those aged 2 to 3 years. As for immunological markers, expression of Thy1-antigen exerted an unfavourable effect on the prognosis and duration of the first remission.

[Monoclonal antibodies ICO-11 in the prognostic evaluation of acute nonlymphoblastic leukemia]. / Monoklonal'nye antitela IKO-11 v otsenke prognoza ostrykh nelimfoblastnykh leikozov.

The antigen detectable with monoclonal antibodies ICO-11 was studied in cells of 33 patients with acute lymphoblastic leukemia (ALL) and 47 patients with acute non-lymphoblastic leukemia (ANLL). The incidence rate of antigen-positive cases in ALL comprised 39.4%, in ANLL 35.4%. The presence of antigen in blasts in ALL did not influence the disease prognosis. The presence of ICO-11+ blasts in ANLL was characteristic of the group of patients with more favourable prognosis: a higher survival rate, due to a higher frequency of remissions, a longer life-time in the absence of remission. Basing on the clinico-hematological data ICO-11+ group could not be identified as more favourable prognostically.

[Immunodiagnosis of acute nonlymphoblastic leukemia in children]. / Immunodiagnostika ostrogo nelimfoblastnogo leikoza u detei.

Seventy-two children with acute nonlymphoblastic leukemia (ANLL) have been studied for expression of different antigens on blast cells with the use of monoclonal antibodies. Myeloid antigens (C3bi; X-hapten) were identified on blast cells most frequently, 58.3%, Ia-like antigen was found in 55% and LFA-1 in 34% of cases. The expression of all antigens except that of LFA-1 was independent on FAB-subtype. It seems necessary in clinical practice to type ANLL cells for the expression of T-cell and myeloid antigens that are of prognostic significance.

[Prognosis of survival time in year prior to the start of radiotherapy of epidermoid carcinoma]. / Prognozirovanie godovoi prodolzhitel'nosti zhizni do nachala luchevoi terapii épidermoidnogo raka.

The results of radiation therapy of 117 patients with squamous cell lung carcinoma taking into account yearly survival were analyzed. Clinico-laboratory and roentgenological factors of prognosis were identified. The use of methods of mathematical statistics and a method of structural risk minimization made it possible to work out a decision rule permitting prognosis of yearly outcome of disease with the minimal probability of 72% even before the start of radiation therapy.

[Individual prognosis of 3-year survival in patients subjected to radical surgery for colonic cancer]. / Individual'noe prognozirovanie 3-letnei vyzhivaemosti radikal'no operirovannykh bol'nykh rakom tolstoi kishki.

A procedure for individual prognosis of surgical treatment of large bowel cancer based on certain clinico-morphological factors is discussed. The procedure is based on the criterion of three-year survival. Computer was used in the evaluation of the prognostic value of each factor using the data available at the Center. The most informative factors were selected to develop a model which gives a reliable prognosis for each case. Application of a multivariate statistical method yielded an optimal combination of prognostic factors and a decision rule was constructed. The credibility of the rule as evaluated on the basis of an additional sample proved to be 91.4%.