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2.
Vopr Onkol ; 25(3): 34-7, 1979.
Article in Russian | MEDLINE | ID: mdl-433202

ABSTRACT

By histoautoradiography DNA was determined in the Heren carcinoma cells during the first 6 days after cryosurgery of the tumor. During 2.5 days after cryosurgery no labeled cells in the cryodestructed tissue were detected. The DNA synthesizing cells were revealed in separate portions of some tumors 66 hours and longer following cryosurgery. The absence of labeled cells during 66 hours since the moment of cryoexposure indicates the block of DNA synthesis in cryoresistant tumor cells. It evidences that the cells which remained viable after cryosurgery were the cause of the recurrences observed.


Subject(s)
Cryosurgery , Neoplasms, Experimental/surgery , Animals , Carcinoma, Squamous Cell/metabolism , Carcinoma, Squamous Cell/physiopathology , Carcinoma, Squamous Cell/surgery , Cell Survival , DNA, Neoplasm/biosynthesis , Male , Neoplasm Transplantation , Neoplasms, Experimental/metabolism , Neoplasms, Experimental/physiopathology , Rats , Thymidine/metabolism , Time Factors
3.
Vopr Onkol ; 24(4): 69-72, 1978.
Article in Russian | MEDLINE | ID: mdl-654177

ABSTRACT

The use of pyrogenal associated with radiotherapy in the experiment (rat sarcoma-45) contributes to a successful realization of radiotherapeutic effect, longer life-terms and non-recurrence period, the increased number of completely cured and survived animals. Pyrogenal would produce no adverse side-effects.


Subject(s)
Pyrogens/therapeutic use , Radiotherapy , Sarcoma, Experimental/therapy , X-Ray Therapy , Animals , Drug Evaluation, Preclinical , Pyrogens/administration & dosage , Radiotherapy Dosage , Rats , Sarcoma, Experimental/mortality , Time Factors
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