[A respiratory splash of monocytes and neutrophils in familial Mediterranean fever].

AIM: To study spontaneous chemotaxis-, phagocytosis-, and proteinkinase C-mediated respiratory splash (RS) of neutrophils and monocytes in colchicin-untreated patients with familial Mediterranean fever (FMF). MATERIAL AND METHODS: Of 17 FMF patients, 8 ones were examined during the attack, 9 patients--in fever-free period. Spontaneous and induced RS of peripheral blood neutrophils and monocytes was investigated with quantitative flow-cytofluorimetric method. RESULTS: Compared to healthy donors, RS is characterized with activation of both spontaneous and induced production of free radicals. The activity and intensity of the RS in FMF was low in the attack vs in the attack-free period but monocytes population has a stable high activity of the RS. CONCLUSION: Activation of neutrophilic RS in FMF patients is characterized by periodicity the direction of which is opposite to induced monocyte activation in the attack and in attack-free interval.

[Effectiveness of using immunomodulators in combined treatment of patients with chronic gastritis and ulcer disease]. / Effektivnost' primeneniia immunomoduliatorov v kompleksnom lechenii bol'nykh khronicheskim gastritom i iazvennoi bolezn'iu.

Clinical and instrumental-laboratory investigations have been conducted in 372 patients with chronic antral gastritis (CAG, n = 131), diffuse gastritis (DG, n = 108) and ulcer disease (UD, n = 135). Immunomodulators tactivin and levamisol were added to standard treatment of 75 CAG, 63 DG and 85 UD patients. Healing of the lesions was observed, on the average, on the treatment day 24.3 +/- 0.5 and 18.4 +/- 0.6 in the standard treatment and with the added immunomodulator, respectively. Adjuvant levamisol diminished the number of recurrences of chronic gastritis and UD.

[Somatic vascular and psycho-emotional disorders in some gastrointestinal diseases and the correction with physical factors]. / Vegetativno-sosudistye i psikhoémotsional'nye narusheniia pri nekotorykh zabolevaniiakh organov pishchevareniia i ikh korrektsiia fizicheskimi faktorami.

Vegetovascular disorders are obligatory and even leading clinical manifestations of chronic gastrointestinal diseases. Physiotherapy in combination with psychotherapy produce a normalizing effect on functional-morphological condition of the gastrointestinal organs, correct alterations in the neuropsychic sphere and autonomic nervous system.

[Clinico-endoscopic data and the status of local immunity in intestinal lesions in patients with periodic disease]. / Kliniko-éndoskopicheskie dannye i sostoianie mestnogo immuniteta pri porazhenii kishechnika u bol'nykh periodicheskoi bolezn'iu.

Clinicoendoscopic and immunological evaluation of periodic disease patients shows that the disease-related inflammation of the colon is pathogenetically coupled with secretory IgA hypoproduction and abnormal intestinal eubiotic microflora. These facts should be allowed for when making differential diagnosis between periodic disease and gastrointestinal inflammations.

[Medicinal leeches: their medical use in the therapy clinic]. / Meditsinskie piiavki: ikh lechebnoe primenenie v terapevticheskoi klinike.

The authors analyze the laboratory and instrumental data obtained before and after single administration of leeches. Demonstrate that the animal's saliva corrects the coagulation properties of the circulating blood; inhibits platelet aggregation; that it may be used for blood letting; possesses hypotensive and anti-sclerotic properties; improves myocardial supply and its contractility. Based on a large clinical material the authors provide evidence for advisability of the use of hirudotherapy in patients suffering from coronary heart disease, essential hypertension, atherosclerosis, chronic cer pulmonale, and circulatory decompensation.

[Selective involvement of the gastrointestinal tract in amyloidosis in a female patient with periodic disease and intact kidneys]. / Izbiratel'noe porazhenie zheludochno-kishechnogo trakta pri amiloidoze u bol'noi periodicheskoi bolezn'iu s intaktnymi pochkami.

The authors describe a rare case of amyloidosis in a female patient suffering from periodic disease (PD) for 18 years without any clinico-laboratory signs of renal impairment but with marked clinical, (malabsorption, cachexia), endoscopic, x-ray and other manifestations of gastrointestinal amyloidosis. This case is of interest since patients suffering from amyloidosis due to PB develop malabsorption very rarely, namely in 2-3% of cases. As a rule, it develops in patients with pronounced chronic renal failure on hemodialysis or with a history of kidney transplantation. In this particular case, the patient demonstrated selective marked damage to the gastrointestinal tract, with the kidneys remaining practically intact. A possibility of the indicated variety of amyloidosis should be considered in specification of the genesis of persistent diarrhea in PB patients.

[Gastroenteropathies in patients with periodic disease and amyloidosis]. / Gastroénteropatii u bol'nykh periodicheskoi bolezn'iu i amiloidozom.

The reported and the authors' data are provided on the pathogenesis, morphofunctional characteristics and clinical manifestations of acute and chronic gastroenteropathies in patients suffering from periodic disease with and without amyloidosis. Under discussion is the significance of changes in the gastrointestinal tract for the diagnosis of periodic disease, its association with other diseases and early recognition of amyloidosis.

[Structural and functional changes in the parathyroid glands in patients with periodic disease]. / Strukturno-funktsional'nye izmeneniia okoloshchitovidnykh zhelez u bol'nykh periodicheskoi bolezn'iu.

The results obtained during radioimmunoassay, biochemistry and morphological studies in patients with periodic disease point to the development of hypoparathyroid hormonemia, reduction of the substrate of the parathyroid parenchyma, responsible for the synthesis of parathyroid hormone. These alterations became aggravated in the course of the development of amyloidosis. The latter is not always related to amyloidosis of the parathyroid glands themselves.

[Immunomorphological evaluation of intestinal function in periodic disease patients]. / Immunomorfologicheskaia otsenka sostoianiia kishechnika u bol'nykh periodicheskoi bolezn'iu.

Based on clinico-endoscopic, x-ray, immunological and immunohistochemical studies the authors demonstrate the role of disorders in the components of humoral and cellular immunity in the development of intestinal inflammation and amyloidosis in patients with periodical disease. Circulatory disorders, congestive hyperemia, edema of the intestinal mucosa, and spasmodic intestinal dyskinesia that develop during an attack of periodical disease are the initial components in the pathogenesis of inflammatory intestinal lesions seen during periodical disease.