[Effect of fatty component in ration and coenzyme Q10 on indices of rat lipid metabolism in ontogenesis].

The studies made on rats of 1, 3, 6 and 12 months with fish, palm and linseed oil included in the ration in combination of KoQ10, showed that beginning from young age till 12 months fatty acid composition of liver depended of fat component in the ration. Long-term consumption of fish fat with age results in significant increase in omega 3 fatty acids. In this case the omega 6 fatty acids level remained rather high being indicative of organism adaptation and inclusion of compensatory mechanisms supporting the required level of omega 6. With rat age the content of of KoQ10 in liver of rats of the control group and animals fed by of KoQ10 and palm oil with of KoQ10 decreased by 15-27%, while the consumption of linseed oil and fish fat with tended to increase the content of KoQ10 by 30 and 35%, respectively.

[Role of polyunsaturated fatty acids in diet therapy of children with allergic diseases]. / Rol' polinenasyshchennykh zhirnykh kislot v lechebnom pitanii detei s allergicheskimi zabolevaniiami.

135 pediatric patients receiving hypoallergic diet were included into the study group. The control group consisted of 20 children. The impact of PUFA omega-3 biologically active supplements (polyen, prima-Oil) was studied in hypoallergic rations. Biochemical indices were simultaneously investigated. The revealed dynamic changes of fatty acid spectrum in plasma and red cell membranes, cellular and humoral immunity status and eicosanoids synthesis were followed by positive clinical changes. Diets enriched with biologically active supplementation (PUPA omega-3) can be recommended for application in pediatric practice.

[Study of the effect of rations containing dietary fiber on the level of total lipids and cholesterol in the blood and liver of the rat during a 6.5-month experiment]. / Izuchenie vliianiia ratsionov, soderzhashchikh pishchevye volokna, na uroven' obshchikh lipidov i kholesterina krovi i pecheni krys v usloviiakh 6.5-mesiachnogo éksperimenta.

The influence of the following food fibers: wheat bran, citrus pectin, microcrystallized cellulose, methyl cellulose, was studied in experiments on male Wistar rats. Basing on the data obtained it has been suggested that the diets with pectin are conducive to secretion of general lipids and sterols from the liver. Comparison of the action of natural food fibers (wheat bran, pectin) with artificial fibers (microcrystallized cellulose, methyl cellulose) has not revealed any changes in the blood cholesterol level. At the same time a lower content of total lipids and cholesterol was recorded in the liver of rats that had received pectin and bran.

[Changes in fatty acid composition of the plasma and erythrocytes in osteochondrosis]. / Izmenenie sostava zhirnykh kislot plazmy krovi i éritrotsitov pri osteokhondroze.

Alteration of fatty acid composition was studied in blood plasma and erythrocytes of 14 patients with osteochondrosis under conditions of relief-diet therapy. During the period of full starvation distinct decrease in content of linoleic and eicosatrienic acids as well as an increase in content of palmitic, oleic and arachidonic acids were detected in blood plasma. Shifts in the ratio linoleic/arachidonic acids towards an increase in content of arachidonic acid appear to occur as a result of adaptation to stress caused by hunger. These alterations in the fatty acid spectrum of blood plasma, observed during starvation, were normalized within two weeks of recreative diet therapy. Deficiency in polyunsaturated fatty acids was not found in erythrocyte membranes under conditions of the relief-diet therapy course used.

[Effect of the ratio of polyunsaturated fatty acids of the omega 6 and omega 3 families in the diet of rats on the cholesterol content of the blood plasma and liver]. / Vliianie sootnosheniia polinenasyshchennykh zhirnykh kislot semeistv omega 6 i omega 3 v ratsione krys na soderzhanie kholesterina v plazme krovi i pecheni.

The influence of polyunsaturated fatty acids omega 6 and omega 3 on the cholesterol level in the blood plasma and liver was studied in rats fed with rations containing no fats during 6 weeks. The total cholesterol content in the blood plasma decreased in the animals given ration with eicosapentaenoic acid (EPA), and the ration containing "Iwashi" sardine fat combined with sunflower oil. In the animals receiving the latter ration the level of free cholesterol in the liver lowered, however, the level of total cholesterol and its esters rose that could be explained by the reduction of the ratio of fatty acids 20:4/18:2 in cholesterol esters.