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Toxicol Lett ; 192(2): 126-33, 2010 Feb 01.
Article in English | MEDLINE | ID: mdl-19850115

ABSTRACT

The aim of the present study was to investigate whether low levels of mono-ortho PCB 118 and di-ortho PCB 153, affect bone composition and strength in ewes (Dala breed) and their foetuses following exposure starting at conception and ending a week before expected delivery. In male foetuses, trabecular bone mineral content at the metaphysis was almost 30% lower in the PCB 118 (49 microg/kg body wt/day) group compared to the control group (corn oil) (ANCOVA, P<0.05). In female foetuses of the PCB 153 (98 microg/kg body wt/day) group trabecular cross-sectional area at the metaphysis was 19% smaller than in the controls (ANCOVA, P<0.05). At the diaphysis a smaller marrow cavity area (up to 24% reduction) was observed in female and male foetuses exposed to PCB 153 compared with controls (ANCOVA, P<0.05). There were also significant differences at the mid diaphyseal measure point between the PCB 153 and the control group females (ANCOVA, P<0.05). Cortical and total bone mineral density, cortical thickness were significantly higher, endosteal circumference shorter and marrow cavity significantly smaller in the PCB 153 group (ANCOVA, P<0.05). In conclusion there were gender dependent effects on bone tissue and cortical bone was more affected than trabecular bone.


Subject(s)
Bone and Bones/drug effects , Environmental Pollutants/toxicity , Fetus/drug effects , Polychlorinated Biphenyls/toxicity , Animals , Bone Density/drug effects , Bone and Bones/metabolism , Diaphyses/drug effects , Diaphyses/metabolism , Environmental Pollutants/metabolism , Female , Fetus/metabolism , Male , Maternal Exposure , Polychlorinated Biphenyls/metabolism , Pregnancy , Sheep, Domestic
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