Mortality from epilepsy in an onchocerciasis-endemic area in West Uganda.

Mortality from epilepsy was investigated in a rural area of West Uganda where epilepsy is found to be closely linked to onchocerciasis. Thirty-three female and 28 male patients (age range 4-58 years, median 15 years) were identified in a population-wide prevalence survey and were followed from June 1994 to March 2001 (observation period 3,929 person-months). Patients had continuing access to antiepileptic drug (AED) treatment with phenobarbital. Eighteen patients died during the period of observation, corresponding to a standardised mortality ratio (SMR) of 7.2 (95% CI 4.4-11.6; P<0.0001). Adherence to treatment was considered good in 36 of 56 patients receiving regular AEDs, with a SMR of 7.4 in this group compared with a SMR of 8.0 for those 20 patients considered poorly adherent. These findings show high mortality in patients with onchocerciasis-associated epilepsy despite regular AED treatment. Epilepsy appears to have a dramatic impact on this community with high Onchocerca volvulus infestation. If the suspected causal relationship between epilepsy and infection with O. volvulus could be confirmed, this would further underline the importance of sustained control efforts against onchocerciasis.

Clinical and electro-clinical classification of epileptic seizure in west Uganda.

When compared to that of industralised countries, the prevalence of epilepsy in developing countries has generally been found to be higher and in some areas extremely high rates of up to 57 cases per 1000 inhabitants have been reported. The reasons for this difference are still widely unknown and detailed epidemiological as well as clinical data are scarce, especially from rural Africa. The present study was conducted in western Uganda, in an area of high epilepsy prevalence, known to be endemic for onchocerciasis. The seizures of all 91 epilepsy patients diagnosed in this area over the period of two years were classified according to the criteria of the International League against Epilepsy. Based on seizure description alone, the predominant seizure was classified as generalised in 57 patients (63%), as partial in 22 (24%) and unclassified in 12 (13%). An EEG record was analysed in 55 out of 91 patients, showing focal epileptiform activity (EA) in 12, multifocal EA in 9 and primarily generalised EA in 6 patients. When in addition to clinical information, the EEG results in the 27 patients with EA were taken in consideration for seizure classification, the proportion of partial seizures increased to 78% (n = 21); inversely the proportion of generalised seizures fell to 22% (n = 6). The predominance of partial seizures would be compatible with a localised brain lesion as a frequent cause for epileptic seizures in the study area. The findings further corroborate recent observations from several African countries of an association between epilepsy and onchocerciasis.

High incidence of epilepsy related to onchocerciasis in West Uganda.

The incidence of epilepsy was assessed in an onchocerciasis endemic area in West Uganda over a period of 4 years. A high overall crude incidence rate of 215 per 100000 person-years was found (age-adjusted: 156 per 100000 person-years) and the incidence in zones of high onchocerciasis endemicity was significantly higher than in low endemic zones (age adjusted rates: 232 per 100000 person-years versus 77 per 100000 person-years; Yates corrected chi2: P < 0.01). The data constitute a baseline for an ongoing intervention study on the effects of onchocerciasis control on epilepsy incidence in the study area. If a causal relationship between onchocerciasis and epilepsy can be confirmed, this would have significant implications for the concept of morbidity due to onchocerciasis and for the prevention of epilepsy in the endemic areas.

Antiepileptic drug treatment in rural Africa: involving the community.

The vast majority of patients with epilepsy in developing countries do not receive adequate medical treatment and an estimated percentage of 80-90% are without any treatment. Poor infrastructure, insufficient availability of drugs and scarcity of trained medical personnel are relevant factors for this situation. Traditional concepts about epilepsy may also affect acceptance and compliance to modern treatment. We report our experience with anti-epileptic drug (AED) treatment in a rural African community with a high prevalence of epilepsy. After identification of the patients during a prevalence survey on epilepsy, the input of the medical service of the district to the treatment scheme was reduced to a 6-monthly medical visit to the area and long-term provision of AED to the patients. Members of the community were integrated as assistants in the distribution of the drugs and community participation was gradually enhanced over the first year of the programme. A cost-sharing system for the financing of the community assistants was introduced and a self-help committee of epilepsy patients and their families was founded. Within the first 20 months the patients showed good compliance as indicated by a growing number of patients presenting for treatment and a low rate of discontinuation of the treatment. A marked improvement could be observed for most of the patients treated with phenobarbitone in terms of reduction of seizure frequency although complete seizure control was achieved in only a few.

The prevalence of epilepsy follows the distribution of onchocerciasis in a west Ugandan focus.

Epidemiological surveys indicate that the prevalence of epilepsy is higher in developing countries than in industrialized countries. Except for neurocystocercosis due to Taenia solium, little is known about possible underlying causes. This article reports the relationship between epilepsy and onchocerciasis in an Onchocerca volvulus endemic area in West Uganda. Individuals complaining of seizures were identified by means of a population census in 12 villages. Active epilepsy was confirmed in 61 of 4743 inhabitants (crude prevalence rate = 1.3%; age-standardized rate = 1.1%). Distribution of epilepsy in the study area was clustered, ranging from a prevalence of 0.2% to 3.4% in different villages. Age-specific prevalence was highest between 10 and 19 years, with a rate of 3.6% for the study are as a whole, and up to 10.0% in villages of high epilepsy prevalence. The prevalence of onchocerciasis in the 10-19-year-old age group was assessed by skin-snip biopsy and ranged from 15% to 85% in different villages. Epilepsy was significantly more frequent in the three villages with the highest levels of O. volvulus endemicity than in other villages (P < 0.0001). Serological testing for T. solium infection was positive in one and borderline in three of 53 epilepsy patients tested. The significant correlation between epilepsy and onchocerciasis did not change when these four patients were excluded from the analysis. These findings suggest a strong association between epilepsy and onchocerciasis in this area. This could have significant implications for the concept of morbidity due to O. volvulus.

The prevalence of epilepsy follows the distribution of onchocerciasis in a Western Uganda focus

Epidemiological surveys indicate that the prevalence of epilepsy is higher in developing countries than in industrialized countries. Except for neurocystocercosis due to Taenia solium; little is known about possible underlying causes. This article reports the relationship between epilepsy and onchocerciasis in an Onchocerca volvulus endemic area in West Uganda. Individuals complaining of seizures were identified by means of apopulation census in 12 villages. Active epilepsy was confirmed in 61 of 4743 inhabitants (crude prevalence rate = 1.3 ; age-standardized rate = 1.1 ). Distribution of epilepsy in the study area was clustered; ranging from a prevalence of 0.2 to 3.4 in difference villages. Age-specific prevalence was highest between 10 and 19 years; with a rate of 3.6 for the study are as a whole; and up to 10.0 in villages of high epilepsy prevalence. The prevalence of onchocerciasis in the 10-19 -year-old age group was assessed by skin-snip biospy and ranged from 15 to 85 in different villages. Epilepsy was significantlymore frequently more frequent in the three villages with the highest levels of O. volvulus emdemicity than in other villages (P0.0001). Serological testing for T. solium infection was positive in one and borderline in three of 53 epilepsy patients tested. The significant correlation between epilepsy and Onchcerciais did not change when these four patients were excluded from the analysis. These findings suggest a strong association between epilepsy and onchocerciasis in this area. This could have significant implications for the concept of morbidity due to O.volvulus

Rheumatoid esophageal disease.

Esophageal diameters were measured in the roentgenogram in 43 patients with rheumatoid arthritis and in 43 healthy subjects matched by sex and age. The incidence of esophageal dilatation in rheumatoid patients was significantly higher than that of healthy subjects (P LESS THAN 0.01). Higher incidence of esophageal dilatation was seen in groups with pulmonary fibrosis and with subcutaneous nodules (P less than 0.01, P less than 0.05 respectively). An orderly relationship between the incidence of esophageal dilatation and the grades of RA test, stage of joint x-ray, or duration of disease were shown. These results suggest the existence of "rheumatoid esophageal disease".