ABSTRACT
Studies of sodium nitrite metabolism and correlation between NaNO2 metabolism and methemoglobin formation in the blood of rats exposed to radiation have been carried out. It has been shown that, along with radiation-induced damage of OHb----MHb dynamic system, an increase in NaNO2 uptake rate by the blood is the factor causing intensification of methemoglobin formation in irradiated animals.
Subject(s)
Nitrites/blood , Radiation Injuries, Experimental/blood , Sodium Nitrite/blood , Animals , Male , Methemoglobinemia/etiology , RatsABSTRACT
Methemoglobin formation was studied in irradiated and intact rats treated with sodium nitrite (7 mg/100 g bw). During combined exposure to two factors (sodium nitrite and irradiation), the biological effect assessed according to blood methemoglobin concentration exceeded the expected value derived upon summation of separate exposures, i.e. the effect appeared to be greater than the additive one.