ABSTRACT
BACKGROUND: This study tested the hypothesis that childhood-onset schizophrenia (COS) is a variant of adult-onset schizophrenia (AOS) by determining if first-degree relatives of COS probands have an increased risk for schizophrenia and schizotypal and paranoid personality disorders. METHODS: Relatives of COS probands (n = 148) were compared with relatives of attention-deficit/hyperactivity disorder (ADHD) (n = 368) and community control (n = 206) probands. Age-appropriate structured diagnostic interviews were used to assign DSM-III-R diagnoses to probands and their relatives. Family psychiatric history was elicited from multiple informants. Diagnoses of relatives were made blind to information about probands' diagnoses. Final consensus diagnoses, which integrated family history, direct interview information, and medical records, are reported in this article. RESULTS: There was an increased lifetime morbid risk for schizophrenia (4.95% +/- 2.16%) and schizotypal personality disorder (4.20% +/- 2.06%) in the parents of COS probands compared with parents of ADHD (0.45% +/- 0.45%, 0.91% +/- 0.63%) and community control (0%) probands. The parents of COS probands diagnosed as having schizophrenia had an early age of first onset of schizophrenia. Risk for avoidant personality disorder (9.41% +/- 3.17%) was increased in the parents of COS probands compared with parents of community controls (1.67% +/- 1.17%). CONCLUSIONS: The psychiatric disorders that do and do not aggregate in the parents of COS probands are remarkably similar to the disorders that do and do not aggregate in the parents of adults with schizophrenia in modern family studies. These findings provide compelling support for the hypothesis of etiological continuity between COS and AOS.
Subject(s)
Family , Paranoid Personality Disorder/epidemiology , Schizophrenia/epidemiology , Schizotypal Personality Disorder/epidemiology , Adolescent , Adult , Age of Onset , Attention Deficit Disorder with Hyperactivity/diagnosis , Attention Deficit Disorder with Hyperactivity/epidemiology , Attention Deficit Disorder with Hyperactivity/genetics , Comorbidity , Family/psychology , Female , Genetic Predisposition to Disease , Humans , Life Tables , Male , Paranoid Personality Disorder/diagnosis , Paranoid Personality Disorder/genetics , Parents/psychology , Personality Disorders/diagnosis , Personality Disorders/epidemiology , Personality Disorders/genetics , Risk , Risk Factors , Schizophrenia/diagnosis , Schizophrenia/genetics , Schizotypal Personality Disorder/diagnosis , Schizotypal Personality Disorder/geneticsABSTRACT
This article summarizes a series of cognitive/neuropsychological studies of children with schizophrenia. One set of studies, which surveyed a broad range of neuropsychological functions, revealed no evidence that children with schizophrenia are consistently impaired in sensory, perceptual, or language functions. Rather, the studies showed that children with schizophrenia performed poorly on tasks requiring sensory, perceptual, and language processing that made extensive demands on information-processing capacity. A second series of studies, which examined visual information processing by manipulating the processing demands of span of apprehension tasks, yielded similar findings. The key characteristic of tasks that elicit impaired performance in children with schizophrenia is that the task makes extensive demands on processing resources. This suggests that these children have limited information-processing capacity. Three hypotheses are proposed concerning the cognitive processes that are impaired in children with schizophrenia: (1) the cognitive processes that seem to be impaired in these children are part of a more general, hierarchically organized attention system; (2) the component processes of the system are subserved by different brain structures; and (3) the structures are part of a network that includes the frontal lobe and thalamus in interaction with the reticular activating system.
Subject(s)
Cognition Disorders/diagnosis , Neurocognitive Disorders/diagnosis , Neuropsychological Tests , Schizophrenia, Childhood/diagnosis , Adolescent , Attention/physiology , Brain/physiopathology , Child , Cognition Disorders/psychology , Female , Follow-Up Studies , Functional Laterality/physiology , Humans , Male , Mental Recall/physiology , Neurocognitive Disorders/physiopathology , Neurocognitive Disorders/psychology , Psychomotor Performance/physiology , Schizophrenia, Childhood/physiopathology , Schizophrenia, Childhood/psychologyABSTRACT
The National Institute of Mental Health Diagnostic Interview Schedule (NIMH-DIS) was administered by trained lay interviewers to a sample of 82 outpatients with clinical diagnoses of DSM-III schizophrenic disorder. Of these subjects, 77 percent were also diagnosed as suffering from DSM-III schizophrenic disorder according to the structured interview (NIMH-DIS) administered by a lay interviewer. The DIS interviews were scrutinized to find the reasons for their discrepancy with the clinical diagnoses. A majority of the DIS-negative schizophrenic subjects acknowledged significant psychopathology in the DIS and missed only one of the six DSM-III criteria items for schizophrenia. Test-retest results showed consistency in the subjects' reporting of lifetime schizophrenic symptoms.
Subject(s)
Psychiatric Status Rating Scales , Schizophrenia/diagnosis , Adult , Delusions/diagnosis , Hallucinations/diagnosis , Humans , MaleABSTRACT
The complex symptomatology of Hispanic Vietnam veterans receiving treatment for post-traumatic stress disorders (PTSD) was explored with the National Institute of Mental Health Diagnostic Interview Schedule, a structured diagnostic interview that yields current and lifetime operational diagnoses (e.g., DSM-III). Social networks and level of acculturation of these veterans were also examined and compared to those of a "control" group and a sample of veterans with DSM-III schizophrenic disorder (both samples included only Hispanic veterans from the Vietnam and post-Vietnam eras). All subjects reported heavy combat stress and met DSM-III criteria for PTSD. Most were very symptomatic and had significant social impairment. PTSD was rarely seen as a discrete entity but appeared instead mixed with symptom clusters cutting across various DSM-III diagnoses. Social networks of PTSD veterans were intermediate in size, frequency of contact with network members, and network density to those of the comparison groups. A distinctive feature of the PTSD group was the high proportion of negative relationships with close family members, especially spouses. "Highly" symptomatic PTSD veterans reported significantly smaller networks, fewer contacts outside the close family circle, and more negative emotionality directed toward family members than "minimally" symptomatic veterans. While all Hispanic groups studied were not significantly different in level of acculturation, PTSD veterans appeared more alienated from their cultural heritage than the other groups. The severe and polymorphous psychopathology found among these veterans suggests that "rap" groups alone may not constitute an adequate therapeutic approach and that more formal psychiatric therapies should be additionally considered in the management of Vietnam-linked PTSD.
