ABSTRACT
BACKGROUND: Melanocytic tumours which colonise basal cell carcinomas (BCC) may be considered as either lentigo maligna (LM) (in situ) or invasive melanomas. OBJECTIVES: To highlight the diagnostic approach and long-term prognosis of LM which colonises BCC. MATERIALS AND METHODS: Using Satter et al.'s classification, we identified a case of BCC colonised by LM and reviewed similar cases in the literature with long-term follow-up. RESULTS: In the absence of melanocytic extension beyond the lamina propria of the BCC compartment, mixed tumours may be considered as LM colonising the BCC, allowing for less invasive surgery. The absence of long-term relapse in our short series supports this diagnosis, rather than invasive melanomas. CONCLUSION: Our case report, review of the literature, and series follow-up illustrate the most recent assessment of melanocytic/BCC tumours, and guide the physician and the pathologist in their recognition and classification, thus allowing them to make the most appropriate therapeutic decisions.
Subject(s)
Carcinoma, Basal Cell/pathology , Eyelid Neoplasms/pathology , Hutchinson's Melanotic Freckle/pathology , Neoplasms, Complex and Mixed/pathology , Skin Neoplasms/pathology , Aged , Carcinoma, Basal Cell/chemistry , Eyelid Neoplasms/chemistry , Female , Humans , Hutchinson's Melanotic Freckle/chemistry , Neoplasms, Complex and Mixed/chemistry , Skin Neoplasms/chemistryABSTRACT
PURPOSE: The hypothesis of this clinical study was to determine whether glucocorticoid use and immobility were associated with in-hospital nutritional risk. METHODS: One hundred and one patients consecutively admitted to the medical wards were enrolled. Current medical conditions, symptoms, medical history, eating and drinking habits, diagnosis, laboratory findings, medications, and anthropometrics were recorded. The Nutrition Risk Score 2002 (NRS-2002) was used as a screening instrument to identify nutritional risk. RESULTS: The results confirmed that glucocorticoid use and immobility are independently associated with nutritional risk determined by the NRS-2002. Constipation could be determined as an additional cofactor independently associated with nutritional risk. CONCLUSIONS: Glucocorticoid treatment, immobility, and constipation are associated with nutritional risk in a mixed hospitalized population. The presence of long-time glucocorticoid use, immobility, or constipation should alert the clinician to check for nutritional status, which is an important factor in mortality and morbidity.
