ABSTRACT
BACKGROUND: Patient safety is a challenge for health care. The aim of this study is to identify the dimensions with the greatest impact on patient safety culture of healthcare staff in a medium-stay hospital; to asses its evolution over time and to check the sensitivity of monitoring indicators. METHODS: Two cross-sectional studies (2013 to 2015) were conducted. The safety culture assessment tool used was the Spanish version of the "Hospital Survey on Patient Safety" (AHRQ). Outcome variable is high perception of safety (score = 75th percentile). INDEPENDENT VARIABLES: socio-demographic characteristics and perceptions of the evaluated dimensions. The association between variables was quantified by Odds Ratio. RESULTS: The mean of perceived safety was similar in both studies: (7.81 and 7.48, N2013= 66; N2015=92). The best aspects evaluated were: "Supervisor actions" and "Teamwork within unit"; the worst evaluated were: "Staffing", "Management support" and "Teamwork across units". Socio-demographic variables had little significance, while a positive perception in some of the considered dimensions was associated with high perceived safety. The most strongly associated aspects were: "Supervisor actions", "Communication openness" and "Problems in transitions". In the comparative study, indicators based on individual dimensions detected changes better than the assessment of the degree of perceived safety. CONCLUSION: The regular assessment of Patient Safety Culture makes it possible to know the status and evolution of professionals' perceptions. The choice of appropriate indicators optimises the information obtained through these surveys.
Subject(s)
Attitude of Health Personnel , Patient Safety , Safety Management/trends , Adult , Cross-Sectional Studies , Female , Health Care Surveys , Hospitals , Humans , Length of Stay , Male , Middle AgedABSTRACT
Fundamento: La seguridad del paciente es un reto para la asistencia sanitaria. El objetivo de este estudio es identificar las dimensiones con mayor impacto sobre la cultura de seguridad en un hospital de media-larga estancia, monitorizar su evolución y comprobar la sensibilidad de los indicadores de seguimiento. Material y métodos: Se realizaron 2 estudios transversales (2013-2015), utilizando la versión española del cuestionario «Hospital Survey on Patient Safety» (AHRQ). Variable resultado: alto grado de seguridad percibida (puntuación ≥ al percentil 75). Variables predictoras: características socio-demográficas y percepciones de las dimensiones evaluadas. La asociación entre variables se cuantificó mediante OddsRatio. Resultados: El grado de seguridad percibida fue similar en ambos estudios: (7,81-7,48; N2013=66; N2015=92). Los aspectos mejor evaluados fueron: «Acciones de los supervisores» y «Trabajo en equipo en la unidad»; los peor evaluados fueron: «Dotación de personal», «Apoyo de la dirección» y «Trabajo en equipo entre unidades». Las variables socio-demográficas presentaron escasa significación, mientras que una percepción positiva de algunas dimensiones consideradas, sí que se asociaba a un alto grado de seguridad percibida. Los aspectos más fuertemente asociados fueron: «Acciones de los supervisores», «Franqueza en la comunicación» y «Problemas en los cambios de turno». En el estudio comparativo de los resultados, los indicadores basados en las dimensiones individuales detectaron mejor los cambios que el grado de seguridad percibida. Conclusiones: La evaluación periódica de la cultura de seguridad permite conocer el estado y la evolución de las percepciones de los profesionales. La elección de indicadores apropiados optimiza la información obtenida a través de estas encuestas (AU)
Background: Patient safety is a challenge for health care. The aim of this study is to identify the dimensions with the greatest impact on patient safety culture of healthcare staff in a medium-stay hospital; to asses its evolution over time and to check the sensitivity of monitoring indicators. Methods: Two cross-sectional studies (2013 to 2015) were conducted. The safety culture assessment tool used was the Spanish version of the «Hospital Survey on Patient Safety» (AHRQ). Outcome variable is high perception of safety (score ≥ 75th percentile). Independent variables: socio-demographic characteristics and perceptions of the evaluated dimensions. The association between variables was quantified by Odds Ratio. Results: The mean of perceived safety was similar in both studies: (7.81 and 7.48, N2013= 66; N2015=92). The best aspects evaluated were: «Supervisor actions» and «Teamwork within unit»; the worst evaluated were: «Staffing», «Management support» and «Teamwork across units». Socio-demographic variables had little significance, while a positive perception in some of the considered dimensions was associated with high perceived safety. The most strongly associated aspects were: «Supervisor actions», «Communication openness» and «Problems in transitions». In the comparative study, indicators based on individual dimensions detected changes better than the assessment of the degree of perceived safety. Conclusion: The regular assessment of Patient Safety Culture makes it possible to know the status and evolution of professionals' perceptions. The choice of appropriate indicators optimises the information obtained through these surveys (AU)
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Patient Safety/standards , Organizational Culture , Health Organizations , Quality Assurance, Health Care/organization & administration , Quality of Health Care/organization & administration , Quality of Health Care/standards , Follow-Up Studies , Surveys and Questionnaires , Length of StayABSTRACT
Olomoucine (2-(2-hydroxyethylamino)-6-benzylamino-9-methylpurine) has been recently described as a competitive inhibitor (ATP-binding site) of the cell cycle regulating p34cdc2/cyclin B, p33cdk2/cyclin A and p33cdk2/cyclin E kinases, the brain p33cdk5/p35 kinase and the ERK1/MAP-kinase. The unusual specificity of this compound towards cell cycle regulating enzymes suggests that it could inhibit certain steps of the cell cycle. The cellular effects of olomoucine were investigated in a large variety of plant and animal models. This compound inhibits the G1/S transition of unicellular algae (dinoflagellate and diatom). It blocks Fucus zygote cleavage and development of Laminaria gametophytes. Stimulated Petunia mesophyl protoplasts are arrested in G1 by olomoucine. By arresting cleavage it blocks the Laminaria gametophytes. Stimulated Petunia mesophyl protoplasts are arrested in G1 by olomoucine. By arresting cleavage it blocks the development of Calanus copepod larvae. It reversibly inhibits the early cleavages of Caenorhabditis elegans embryos and those of ascidian embryos. Olomoucine inhibits the serotonin-induced prophase/metaphase transition of clam oocytes; furthermore, it triggers the the release of these oocytes from their meiotic metaphase I arrest, and induces nuclei reformation. Olomoucine slows down the prophase/metaphase transition in cleaving sea urchin embryos, but does not affect the duration of the metaphase/anaphase and anaphase/telophase transitions. It also inhibits the prophase/metaphase transition of starfish oocytes triggered by various agonists. Xenopus oocyte maturation, the in vivo and in vitro phosphorylation of elongation factor EF-1 are inhibited by olomoucine. Mouse oocyte maturation is delayed by this compound, whereas parthenogenetic release from metaphase II arrest is facilitated. Growth of a variety of human cell lines (rhabdomyosarcoma cell lines Rh1, Rh18, Rh28 and Rh30; MCF-7, KB-3-1 and their adriamycin-resistant counterparts; National Cancer Institute 60 human tumor cell lines comprising nine tumor types) is inhibited by olomoucine. Cell cycle parameter analysis of the non-small cell lung cancer cell line MR65 shows that olomoucine affects G1 and S phase transits. Olomoucine inhibits DNA synthesis in interleukin-2-stimulated T lymphocytes (CTLL-2 cells) and triggers a G1 arrest similar to interleukin-2 deprivation. Both cdc2 and cdk2 kinases (immunoprecipitated from nocodazole- and hydroxyurea-treated CTLL-2 cells, respectively) are inhibited by olomoucine. Both yeast and Drosophila embryos were insensitive to olomoucine. Taken together the results of this Noah's Ark approach show that olomoucine arrests cells both at the G1/S and the G2/M boundaries, consistent with the hypothesis of a prevalent effect on the cdk2 and cdc2 kinases, respectively.
Subject(s)
Cyclin-Dependent Kinases/antagonists & inhibitors , Enzyme Inhibitors/pharmacology , Growth Inhibitors/pharmacology , Purines/pharmacology , Animals , Cell Cycle/drug effects , Humans , In Vitro Techniques , Kinetin , Lymphocyte Activation/drug effects , Mitosis/drug effects , Oocytes/drug effects , T-Lymphocytes/drug effects , Tumor Cells, Cultured/drug effectsSubject(s)
Retinal Detachment/surgery , Sutures , Animals , Polydioxanone , Polyesters , Polyglactin 910 , Polyglycolic Acid , RabbitsABSTRACT
In a randomized, double-blind study, 12 and 16 mg of metergoline and 5 mg of bromoergocriptine were given daily to three groups of 100 women each for ten consecutive days to prevent lactation. Excellent or good results were obtained in 86%, 90% and 83%, respectively. Serum prolactin (PRL) levels were evaluated in three settings. The first was after a single dose in four groups of patients (4, 6 and 8 mg of metergoline and 2.5 mg of bromoergocriptine were studied for ten hours). Second, for a study of the suckling reflex, PRL levels were measured 15, 30 and 60 minutes after breast stimulation in four groups of five patients each: two groups on the fourth postpartum day with and without metergoline treatment and two groups on the eighth postpartum day (the reflex was suppressed in the two groups treated with metergoline). Third, serum PRL levels rose after the intravenous administration of 200 mg of thyrotropin-releasing hormone (TRH) in another two groups of ten patients, one treated with metergoline and the other not so treated. TRH stimulation was not blocked in the treated groups.
Subject(s)
Ergolines/therapeutic use , Lactation/drug effects , Metergoline/therapeutic use , Prolactin/antagonists & inhibitors , Bromocriptine/therapeutic use , Double-Blind Method , Female , Humans , Pregnancy , Prolactin/blood , Random Allocation , Sucking Behavior/physiology , Time FactorsABSTRACT
The authors study the nyctohemeral changes of prolactin and growth hormone during the evolution of breast cancer and in fibrocystic mastopathy. Prolactin shows a circadian rhythm with higher amounts during sleep in cancer patients. Changes are not significant for fibrocystic mastopathy, although there is a tendency towards higher concentrations than in the control group. No significant changes were observed for the growth hormone.
Subject(s)
Breast Neoplasms/physiopathology , Circadian Rhythm , Pituitary Gland, Anterior/metabolism , Prolactin/metabolism , Adult , Aged , Breast Neoplasms/surgery , Female , Fibrocystic Breast Disease/physiopathology , Growth Hormone/metabolism , Humans , Mastectomy , Menopause , Middle Aged , Postoperative PeriodABSTRACT
Basal and stimulatory tests of FSH, LH and PRL are reported in three cases of hypogonadism-anosmia syndrome (Maestre-Kallmann-De Morsier syndrome), two of whom were brothers. Basal FSH levels were low (mean = 1.7 mU/ml) and did not respond to the first acute stimulation with intravenous LRH (x = 2.3 mU/ml), but after intramuscular LRH, 500 microgram/day for 10 days, a clear-cut response was noted in two patients (from a mean of 7.8 mU/ml to 16.8 mU/ml), while the other patient continued without response. Low basal LH levels (mean 1.8 mU/ml) responded poorly to the first LRH stimulation (mean 4.6 mU/ml), while after intramuscular LRH for 10 days there was a marked increase in all three cases (mean 29.7 mU/ml). In no case was there a response to clomiphene. With regard to PRL, all cases had a clear response to TRH, although it was subnormal in two of them. Opposite results were obtained in one case of Klinefelter's syndrome, namely, elevated basal PRL levels (44 ng/ml) with an exaggerated response to TRH. Chlorpromazine administration caused an elevation of PRL to 43 and 30 ng/ml, respectively, in the two patients with a subnormal response to TRH, while the third case responded less than to TRH. In conclusion, the response to TRH of FSH and LH with lack of response to clomiphene supports the hypothalamic nature of the hypogonadism, while the response of PRL to both TRH and chlorpromazine, along with the normal levels of the remaining pituitary hormones (ACTH, TSH and STH) demonstrate the selectivity of the hypothalamic lesion whereby only gonadotrophin control is impaired.
Subject(s)
Chlorpromazine/therapeutic use , Hypogonadism/drug therapy , Olfaction Disorders/drug therapy , Prolactin/metabolism , Thyrotropin-Releasing Hormone/therapeutic use , Adolescent , Adult , Female , Follicle Stimulating Hormone/metabolism , Humans , Hypogonadism/genetics , Hypogonadism/metabolism , Luteinizing Hormone/metabolism , Male , Olfaction Disorders/genetics , Olfaction Disorders/metabolism , Stimulation, Chemical , SyndromeABSTRACT
The authors review any possible correlation between prolactin and growth hormone in human breast cancer. They find neither a significant relationship between growth hormone and breast cancer nor between prolactin and growth hormone. In many cases however, prolactin levels may be used as a neoplastic marker. The excess of prolactin could originate either in a tumor factor stimulating its secretion by the hypophysis or in an ectopic production of the hormone by tumor tissue.
Subject(s)
Breast Neoplasms/physiopathology , Growth Hormone/physiology , Prolactin/physiology , Adult , Age Factors , Aged , Breast Neoplasms/blood , Breast Neoplasms/surgery , Climacteric , Female , Growth Hormone/blood , Humans , Menopause , Middle Aged , Neoplasm Metastasis , Postoperative Period , Prolactin/bloodABSTRACT
PIP: The authors report on 59 cases of lactation inhibition by different drugs (placebo, etilbestrol, vitamin B6 and bromocriptine). The patients were between 20-30 and did not wish to breastfeed. Relation between basal levels of prolactin (PRLH) and breast turgency, pain, and milk secretion was studied. Examinations were done 24 hours after delivery, and again 7 and 14 days later. There was a significant correlation between basal levels of PRLH and breast turgency at every examination. Pain was related to prolactinemia only 7 and 14 days after delivery, while milk secretion had a significant correlation with prolactinemia 24 hours after delivery, and again 7 days later, but not at the time of the third examination.^ieng
