1.
Am J Kidney Dis
; 33(2): E8, 1999 Feb.
Article
in English
| MEDLINE
| ID: mdl-10074608
ABSTRACT
In some individuals, chronic lymphocytic leukemia (CLL) may be associated with glomerular disease from membranous nephropathy with resultant nephrotic syndrome. CLL is characterized by abnormal immunoregulation with a malignant clonal proliferation of lymphocytes. The association between the abnormal clone and nephrotic syndrome is suggested in some cases by the remission of proteinuria with a reduction in abnormal lymphocyte number after treatment with antineoplastic agents. For the first time, we describe a patient with CLL and associated membranous glomerulopathy whose nephrotic syndrome remitted after treatment with fludarabine, a new purine analogue used in the treatment of refractory CLL.
Subject(s)
Antineoplastic Agents/therapeutic use , Glomerulonephritis, Membranous/drug therapy , Leukemia, Lymphocytic, Chronic, B-Cell/complications , Vidarabine/analogs & derivatives , Biopsy , Female , Glomerulonephritis, Membranous/diagnosis , Glomerulonephritis, Membranous/etiology , Humans , Kidney/pathology , Vidarabine/therapeutic use
2.
Perit Dial Int
; 15(8): 367-9, 1995.
Article
in English
| MEDLINE
| ID: mdl-8785237
3.
Chest
; 99(3): 724-9, 1991 Mar.
Article
in English
| MEDLINE
| ID: mdl-1995229