Cellular junction dynamics and Alzheimer's disease: a comprehensive review.

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by progressive neuronal damage and cognitive decline. Recent studies have shed light on the involvement of not only the blood-brain barrier (BBB) dysfunction but also significant alterations in cellular junctions in AD pathogenesis. In this review article, we explore the role of the BBB and cellular junctions in AD pathology, with a specific focus on the hippocampus. The BBB acts as a crucial protective barrier between the bloodstream and the brain, maintaining brain homeostasis and regulating molecular transport. Preservation of BBB integrity relies on various junctions, including gap junctions formed by connexins, tight junctions composed of proteins such as claudins, occludin, and ZO-1, as well as adherence junctions involving molecules like vascular endothelial (VE) cadherin, Nectins, and Nectin-like molecules (Necls). Abnormalities in these junctions and junctional components contribute to impaired neuronal signaling and increased cerebrovascular permeability, which are closely associated with AD advancement. By elucidating the underlying molecular mechanisms governing BBB and cellular junction dysfunctions within the context of AD, this review offers valuable insights into the pathogenesis of AD and identifies potential therapeutic targets for intervention.

The impact of zinc on the molecular signaling pathways in the diabetes disease.

Since there's been an upsurge in people with diabetes or pre-diabetes conditions, many studies have been conducted to evaluate approaches for reducing the complications of diabetes. One of the most common therapeutic elements suggested for this purpose is zinc (Zn). Zn has long been shown to positively improve complications of both type 1 and type 2 diabetes. This review aims to provide comprehensive information about the influence of Zn on the various signaling pathways in multiple tissues with diabetic conditions, with great attention to the treatment period and effective dose of Zn.

Performance evaluation and siting index of the stabilization ponds based on environmental parameters: a case study in Iran.

Stabilization ponds are open pools that remove total suspended solids, organic matters, microbial and pathogenic agents using physical, chemical, and biological processes. If the stabilization ponds are not well designed, they can produce odors, breed many insects, increase suspended solids concentration in the effluent and pollute groundwater. Consideration of environmental factors is critical for operation and maintenance. In this study, first, information on wastewater treatment plants and meteorological parameters were collected, and simultaneously, specialists were selected to score the effect of environmental factors on stabilization pond efficiency. A geographic information system was used to sit for suitable locations for stabilization ponds. The results showed that 23.6 % of Iran's treatment plants are stabilization ponds, which based on climate, evaporation, sunny hours, ice days, wind speed, and temperature parameters, 33.33 %, 37.3 %, 14 %, 50 %, 64 and 26 % of the stabilization ponds have obtained good points, respectively. The results also showed that 50 % of the stabilization ponds obtained an acceptable score considering all environmental parameters' simultaneous effect. A preliminary study based on considering all the environmental parameters showed that the central and southern regions are the best areas for establishing waste stabilization ponds; in contrast, northern and northeastern regions can have high operation and maintenance costs with lower efficiency. This study has shown that setup and design of the new waste stabilization ponds in Iran need to take into account by considering environmental factors because these factors have the main effect on algae growth which are one of main biological treatment.