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Rodgers, T R; LaMontagne, M P; Markovac, A; Ash, A B.

J Med Chem ; 20(4): 591-4, 1977 Apr.

Article in English | MEDLINE | ID: mdl-850246

ABSTRACT

A series of 27 hydantoins was prepared and tested as antitumor agents. These were variously substituted in the 5 position but with special emphasis on the substituents (chloro, acetyl, chloroacetyl, and methyl) in the 1 and/or 3 positions. The most active compound was 5,5-bis(4-chlorophenyl)-1,3-dichlorohydantoin with a T/C value of 190% against P-388 lymphocytic leukemia in mice.

Subject(s)

Antineoplastic Agents/chemical synthesis , Hydantoins/chemical synthesis , Animals , Antineoplastic Agents/therapeutic use , Hydantoins/pharmacology , Hydantoins/therapeutic use , Leukemia L1210/drug therapy , Leukemia, Experimental/drug therapy , Methods , Mice

New reactivators of phosphonylated acetylcholinesterase.

Steinberg, G M; Cramer, J; Ash, A B.

Biochem Pharmacol ; 26(5): 439-41, 1977 Mar 01.

Article in English | MEDLINE | ID: mdl-849335

Subject(s)

Acetylcholinesterase/metabolism , Organophosphonates/pharmacology , Pyridinium Compounds/pharmacology , Animals , Cholinesterase Inhibitors , Eels , Enzyme Activation/drug effects , Kinetics , Mathematics , Oximes/pharmacology , Structure-Activity Relationship

Antimalarials. 3. 2,6-Bis(aryl)-4-pyridinemethanols with trifluoromethyl substituents.

Markovac, A; LaMontagne, M P; Blumbergs, P; Ash, A B; Stevens, C L.

J Med Chem ; 15(9): 918-22, 1972 Sep.

Article in English | MEDLINE | ID: mdl-5051009

Subject(s)

Antimalarials/chemical synthesis , Pyridines/chemical synthesis , Animals , Antimalarials/therapeutic use , Fluorine , Malaria/drug therapy , Methanol/chemical synthesis , Methanol/therapeutic use , Methylation , Mice , Pyridines/therapeutic use , Structure-Activity Relationship

Antimalarials. 2. 2,6-Bis(aryl)-4-pyridinemethanols.

Blumbergs, P; LaMontagne, M P; Markovac, A; Moehring, J G; Ash, A B; Stevens, C L.

J Med Chem ; 15(8): 808-12, 1972 Aug.

Article in English | MEDLINE | ID: mdl-5044296

Subject(s)

Antimalarials/chemical synthesis , Pyridines/chemical synthesis , Animals , Antimalarials/therapeutic use , Benzene Derivatives/chemical synthesis , Benzene Derivatives/therapeutic use , Malaria/drug therapy , Methanol/chemical synthesis , Methanol/therapeutic use , Mice , Pyridines/therapeutic use , Structure-Activity Relationship

Antimalarials. 1. 2-Quinolinemethanols.

Markovac, A; Stevens, C L; Ash, A B.

J Med Chem ; 15(5): 490-3, 1972 May.

Article in English | MEDLINE | ID: mdl-5035268

Subject(s)

Antimalarials/chemical synthesis , Quinolines/chemical synthesis , Animals , Antimalarials/pharmacology , Antimalarials/therapeutic use , Malaria/drug therapy , Methanol/chemical synthesis , Methanol/therapeutic use , Mice , Microbial Sensitivity Tests , Plasmodium/drug effects , Quinolines/pharmacology , Quinolines/therapeutic use , Structure-Activity Relationship

Nucleotide synthesis. I. Derivatives of thymidine containing p-nitrophenyl phosphate groups.

Glinski, R P; Ash, A B; Stevens, C L; Sporn, M; Lazarus, H M.

J Org Chem ; 36(2): 245-9, 1971 Jan 29.

Article in English | MEDLINE | ID: mdl-5545351

Subject(s)

Nucleotides/chemical synthesis , Thymidine , Chromatography, Paper , Cyanides , Deoxyribonucleases , Nitrobenzenes , Ribonucleases , Spectrum Analysis , Staphylococcus/enzymology

Amino ketone rearrangements. VI. Synthesis of 2-alkylamino-2-phenylcyclohexanones.

Stevens, C L; Ash, A B; Thuillier, A; Amin, J H; Balys, A; Dennis, W E; Dickerson, J P; Glinski, R P; Hanson, H T; Pillai, M D; Stoddard, J W.

J Org Chem ; 31(8): 2593-601, 1966 Aug.

Article in English | MEDLINE | ID: mdl-5917446

Subject(s)

Ketones , Chemistry, Organic , Organic Chemistry Phenomena

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