Catalyst-free thiophosphorylation of in situ formed ortho-quinone methides.

A metal-, chloride reagent and base-free thiophosphorylation reaction of in situ formed ortho-quinone methide (o-QM) to synthesize functionalized thiophosphates has been developed. The reaction is an atom-economical process, producing water as the sole byproduct. (EtO)2P(O)SH functions as both a Brønsted acid and nucleophilic thiolate to produce the o-QM intermediate and the thiophosphate product, respectively. The aza o-QMs were also successfully thiophosphorylated in the presence of catalytic TsOH to form sulfonamido thiophosphates.

Selective hydrolysis of phosphorus(V) compounds to form organophosphorus monoacids.

An azide and transition metal-free method for the synthesis of elusive phosphonic, phosphinic, and phosphoric monoacids has been developed. Inert pentavalent P(v)-compounds (phosphonate, phosphinate, and phosphate) are activated by triflate anhydride (Tf2O)/pyridine system to form a highly reactive phosphoryl pyridinium intermediate that undergoes nucleophilic substitution with H2O to selectively deprotect one alkoxy group and form organophosphorus monoacids.

Metal- and chloride reagent-free synthesis of mixed thiophosphates.

A mild, efficient synthetic strategy for the synthesis of mixed thiophosphate compounds from thiophosphates has been developed. A highly reactive thiophosphorylpyridinium salt, generated in situ by treating thiophosphates with Tf2O/pyridine, transiently undergoes a substitution reaction with various arenols to forge potential agrochemicals and pharmaceuticals.

Tf2O-Promoted Activating Strategy of Phosphate Analogues: Synthesis of Mixed Phosphates and Phosphinate.

A metal-, toxic chloride reagent-free activating strategy of various phosphates has been developed. This method enables the facile synthesis of functional phosphates such as alkyl phosphates, aza phosphates, thiophosphate, and mixed diaryl phosphates. A transient phosphorylpyridin-1-ium species in situ generated from phosphates with Tf2O/pyridine readily undergoes a substitution reaction with diverse nucleophiles to form versatile phosphate compounds.

Base-controlled Fe(Pc)-catalyzed aerobic oxidation of thiols for the synthesis of S-S and S-P(O) bonds.

Fe(Pc)-Catalyzed aerobic oxidation of thiols for the synthesis of disulfides has been developed under mild reaction conditions. In addition, an aerobic oxidative cross-dehydrogenative coupling (CDC) reaction of thiols with P(O)-H compounds (H-phosphonates and H-phosphine oxide) for the formation of S-P(O) bonds has been demonstrated under the Fe(Pc) catalysis system with a base additive. Control experiments revealed that the use of a base (DIPA) in this system controls the synthetic pathways in which thiophosphates are formed.

The changing face of academic nursing: Nurturing diversity, inclusivity, and equity.

This paper captures collective experiences of nursing and organizational leaders in creating organizational cultures attentive to diversity, inclusivity, and equity in schools of nursing. Within a cultural proficiency framework, exemplars and leadership lessons are shared. Most importantly, what it takes organizationally to start the ongoing journey towards cultural proficiency is explored. Ensuring the intentional systematic change at multiple levels facilitates sustainability when leadership changes occur.