Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters










Database
Language
Publication year range
1.
Expert Opin Drug Saf ; 15(12): 1635-1642, 2016 Dec.
Article in English | MEDLINE | ID: mdl-27689239

ABSTRACT

INTRODUCTION: Hypertensive disorders have become increasingly prevalent and complicate an increasing number of pregnancies. Therefore it is essential that the medications used to treat these disorders be well understood. Furthermore the management is complicated by special consideration needed for the physiologic changes of pregnancy as well as the consideration for possible adverse fetal effects. Areas covered: We performed a review of the scientific literature of medications used to treat hypertensive disorders in pregnancy. We reviewed the guidelines used by different societies all over the world. We also discussed the pharmacodynamics, pharmacokinetics and possible adverse effects relating to the antihypertensive medications. Finally, we discussed the long-term maternal implications of these diseases. Expert opinion: Overall, we encourage a step-wise approach to treating hypertensive disorders of pregnancy. While making sure to max out the use of one medications prior to shifting to another. Also, it is imperative not to be aggressive with treatment due to risk of compromising utero-placental blood flow. There is research currently involving biomarkers, nano-medicine and the placenta project with hopes of developing new targeted medications with a good fetal safety profile.


Subject(s)
Antihypertensive Agents/therapeutic use , Hypertension, Pregnancy-Induced/drug therapy , Practice Guidelines as Topic , Antihypertensive Agents/adverse effects , Antihypertensive Agents/pharmacokinetics , Female , Fetus/drug effects , Humans , Hypertension, Pregnancy-Induced/epidemiology , Placenta/blood supply , Postpartum Period , Pregnancy
2.
Hypertension ; 65(2): 430-9, 2015 Feb.
Article in English | MEDLINE | ID: mdl-25452470

ABSTRACT

C-reactive protein (CRP), an innate immune mediator, is elevated in the circulation before symptoms in patients with preeclampsia, a severe hypertensive pregnancy disorder with high mortality and morbidity. However, the specific sources underlying increased CRP and the role of elevated CRP in preeclampsia are undefined. Here, we report that circulating CRP levels are significantly increased in a large cohort of normotensive pregnant individuals when compared with nulligravid women and is further increased in patients with preeclampsia. These findings led us to discover further that placental syncytiotrophoblasts are previously unrecognized cellular sources of CRP and underlie elevated CRP in normotensive pregnant women and the additional increase in patients with preeclampsia. Next, we demonstrated that injection of CRP induces preeclampsia features, including hypertension (157 mm Hg CRP treated versus 119 mm Hg control), proteinuria (35.0 mg/µg CRP treated versus 14.1 mg/µg control), kidney, and placental damage and increased levels of sFlt-1 in pregnant mice but not in nonpregnant mice. Our study implicates that phosphocholine transferase, a placental-specific enzyme post-translationally modifying neurokinin B, is essential for the pathogenic role of CRP in preeclampsia through activation of the neurokinin 3 receptor. Overall, our studies have provided significant new insight on the pathogenic role of CRP in preeclampsia and highlighted innovative therapeutic strategies.


Subject(s)
C-Reactive Protein/physiology , Choline-Phosphate Cytidylyltransferase/physiology , Neurokinin B/metabolism , Pre-Eclampsia/etiology , Receptors, Neurokinin-3/physiology , Animals , Biomarkers , C-Reactive Protein/analysis , C-Reactive Protein/toxicity , Choline-Phosphate Cytidylyltransferase/antagonists & inhibitors , Disease Models, Animal , Double-Blind Method , Female , Humans , Kidney/pathology , Mice , Mice, Inbred C57BL , Phosphorylation , Phosphorylcholine/metabolism , Placenta/pathology , Pre-Eclampsia/chemically induced , Pre-Eclampsia/metabolism , Pre-Eclampsia/pathology , Pregnancy , Protein Binding , Protein Processing, Post-Translational , Quinolines/pharmacology , RNA, Small Interfering/pharmacology , RNA, Small Interfering/therapeutic use , Receptors, Neurokinin-3/antagonists & inhibitors , Receptors, Neurokinin-3/metabolism , Recombinant Proteins/toxicity , Single-Blind Method , Vascular Endothelial Growth Factor Receptor-1/blood
SELECTION OF CITATIONS
SEARCH DETAIL
...