ABSTRACT
Posttraumatic and postsurgical sensory disturbance is a known complication of almost all zygomaticomaxillary (ZMC) complex fractures involving the infraorbital nerve, for which few treatments are effective. Our study used neurosensory assessments to evaluate the efficacy of melatonin on pain and nerve healing following ZMC surgery. Sixty-four randomly allocated ZMC fracture patients were prophylactically administered either oral melatonin or an identical placebo for 15 consecutive days. Pre- and postsurgical clinical parameters included subjective pain, numbness, and objective neurosensory function. Melatonin significantly reduced subjective pain perception in the early postoperative days, with a significant difference in VAS scores between the groups from postoperative day 3 (p = 0.048) until day 7 (p = 0.002). The VAS assessment of subjective numbness perception showed significantly lower self-perceived neurosensory disturbance for patients in the interventional group from the first month (p = 0.039) until the third month (p = 0.005). Objective neurosensory assessment using the pinprick test and two-point discrimination showed statistically significant improvement to almost normal sensation by the first month (p = 0.014) to fully normal sensation by the third month (p = 0.001). The study findings suggest that the prophylactic administration of melatonin confers significant clinical benefits in terms of reduced postoperative pain and improved sensory recovery.
Subject(s)
Maxillary Fractures , Melatonin , Pain, Postoperative , Zygomatic Fractures , Humans , Melatonin/therapeutic use , Zygomatic Fractures/surgery , Pain, Postoperative/prevention & control , Pain, Postoperative/drug therapy , Male , Female , Adult , Maxillary Fractures/surgery , Middle Aged , Pain Measurement , Young Adult , Double-Blind Method , Hypesthesia/etiology , Recovery of Function/drug effectsABSTRACT
INTRODUCTION: Although numerous syndromic and non-syndromic odontogenic lesions of the jaws have been documented in the literature, there are very few cases of simultaneous benign and malignant jaw lesions. PATIENT CONCERNS: We present a case of right maxillary squamous cell carcinoma along with several benign odontogenic cystic lesions of the jaws and skeletal abnormalities that meet the criteria for Gorlin-Goltz syndrome. TAKEAWAY LESSONS: With a review of the literature, the specifics of management and follow-up are discussed.
Subject(s)
Basal Cell Nevus Syndrome , Maxillary Neoplasms , Odontogenic Cysts , Humans , Basal Cell Nevus Syndrome/pathology , Basal Cell Nevus Syndrome/complications , Odontogenic Cysts/diagnostic imaging , Odontogenic Cysts/pathology , Maxillary Neoplasms/pathology , Maxillary Neoplasms/diagnostic imaging , Carcinoma, Squamous Cell/pathology , Male , Neoplasms, Multiple Primary/pathology , Neoplasms, Multiple Primary/diagnostic imaging , Radiography, Panoramic , FemaleABSTRACT
Haemangiomas of the oral cavity are common benign vascular tumours of infancy. Several treatment modalities are described for haemangiomas, including sclerotherapy, embolisation, laser surgery and cryotherapy. Cryotherapy is the application of varying extremes of low temperatures to destroy abnormal tissue. Since cryosurgery is effective, simple and easy to perform, it is used in the treatment of lesions in both medicine and dentistry. Cryosurgery provides many advantages such as easy operation, absence of intraoperative bleeding and low infection rate. In this case, the cryosurgical treatment of a young patient who suffered from multiple haemangiomas of the oral cavity that was refractory to medical treatment is presented.
