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Exp Clin Transplant ; 9(1): 68-71, 2011 Feb.
Article in English | MEDLINE | ID: mdl-21605027

ABSTRACT

OBJECTIVES: We report a case of central nervous system coinfection with 2 types of opportunistic organisms-Aspergillus and Mycobacterium tuberculosis-in a 33-year-old woman who underwent a renal transplant. MATERIALS AND METHODS: She developed a high-grade fever and right-sided weakness 1 month after the transplant while on mycophenolate mofetil, prednisolone, and cyclosporine. RESULTS: Brain magnetic resonance imaging revealed multiple mass lesions with peripheral ring enhancement. Colony-stimulating factor polymerase chain reaction was positive for Aspergillus and Mycobacterium tuberculosis. CONCLUSIONS: Broad-spectrum antibiotics, antituberculous agents, and amphotericin were started. Unfortunately, the woman's condition deteriorated, and she died 2 weeks after admission to the hospital.


Subject(s)
Aspergillus/isolation & purification , Immunosuppressive Agents/adverse effects , Kidney Transplantation/adverse effects , Meningoencephalitis/microbiology , Mycobacterium tuberculosis/isolation & purification , Tuberculosis, Meningeal/microbiology , Adult , Anti-Bacterial Agents/therapeutic use , Antifungal Agents/therapeutic use , Antitubercular Agents/therapeutic use , Aspergillus/genetics , Bacteriological Techniques , Cyclosporine/adverse effects , DNA, Bacterial/isolation & purification , DNA, Fungal/isolation & purification , Drug Therapy, Combination , Fatal Outcome , Female , Humans , Magnetic Resonance Imaging , Meningoencephalitis/diagnosis , Meningoencephalitis/drug therapy , Mycobacterium tuberculosis/genetics , Mycophenolic Acid/adverse effects , Mycophenolic Acid/analogs & derivatives , Polymerase Chain Reaction , Prednisolone/adverse effects , Treatment Failure , Tuberculosis, Meningeal/diagnosis , Tuberculosis, Meningeal/drug therapy
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