ABSTRACT
Primary squamous cell carcinoma (SCC) of ampulla has seldom been reported. However, metastatic SCC to ampulla of Vater is well known. We report a case of primary SCC of ampulla of Vater coexistent with well-differentiated adenocarcinoma of the distal pancreatic duct. A 50-year-old female presented with evidence of obstructive jaundice. Endoscopic retrograde cholangio-pancreatography revealed bulging papilla with ulcero-infiltrative growth at the ampulla of Vater. An initial endoscopic biopsy of the ampullary mass showed a well-differentiated SCC. The patient underwent Whipple's operation. Thorough sampling of the dilated portion of the pancreatic duct showed presence of well-differentiated adenocarcinoma of the distal pancreatic duct. Immunohistochemical study with synaptophysin and chromogranin was done with negative result, ruling out neuroendocrine differentiation. Also, a detailed clinical, endoscopic and radiological examination was carried out, that excluded the presence of primary SCC elsewhere.
Subject(s)
Ampulla of Vater/pathology , Carcinoma, Pancreatic Ductal/diagnosis , Common Bile Duct Neoplasms/diagnosis , Neoplasms, Multiple Primary/diagnosis , Pancreatic Neoplasms/diagnosis , Pancreaticoduodenectomy/methods , Ampulla of Vater/surgery , Biopsy , Carcinoma, Pancreatic Ductal/surgery , Carcinoma, Squamous Cell , Cholangiopancreatography, Endoscopic Retrograde , Common Bile Duct Neoplasms/surgery , Diagnosis, Differential , Female , Follow-Up Studies , Humans , Middle Aged , Neoplasms, Multiple Primary/surgery , Pancreatic Neoplasms/surgeryABSTRACT
INTRODUCTION: Extra-cranial meningioma or ectopic meningioma is a rare tumor. This tumor has been reported in various anatomic sites in the head and neck, mediastinum, skin and soft tissues. We report a rare case of ectopic meningioma in the submandibular region detected by using fine-needle aspiration cytology, histopathology and immunohistochemistry. This case represents another unusual site for extra-cranial meningioma, which prompted us to report it. CASE PRESENTATION: An 18-year-old Dravidian woman presented with swelling in the right submandibular region. The computed tomographic scan findings were suggestive of a neoplastic mass lesion in the right submandibular region. Fine-needle aspiration cytology led to the differential diagnosis of a monomorphic adenoma of a salivary gland or an ectopic meningioma. The patient underwent excision of the submandibular gland and tumor. The histological examination and immunohistochemistry studies confirmed that the lesion was an extra-cranial meningioma. At her two-year follow-up examination, there was no recurrence of the tumor. CONCLUSION: Our experience with this case indicates that, although rare, meningioma should be entertained in the differential diagnosis of a mass lesion in the head and neck region.
ABSTRACT
Massive retinal gliosis (MRG) is a rare, benign intraocular condition that results from the proliferation of well-differentiated glial cells. Immunohistochemically, these cells show positivity for glial fibrillary acid protein (GFAP), neuron specific enolase (NSE), and S-100 protein. We encountered a case of a 45-year-old female with loss of vision in the left eye. She had a history of trauma to that eye two years ago. Enucleation was carried out, because malignancy was suspected due to retinal calcification. On the basis of light microscopy and immunohistochemistry (IHC) performed on the enucleated eye, it was diagnosed as massive retinal gliosis.
Subject(s)
Gliosis/diagnosis , Gliosis/metabolism , Immunohistochemistry , Retinal Diseases/diagnosis , Retinal Diseases/metabolism , Blindness/etiology , Blindness/surgery , Eye Enucleation , Female , Glial Fibrillary Acidic Protein/metabolism , Gliosis/complications , Gliosis/physiopathology , Humans , Middle Aged , Phosphopyruvate Hydratase/metabolism , Retinal Diseases/complications , Retinal Diseases/physiopathology , S100 Proteins/metabolism , Severity of Illness Index , Tomography, X-Ray Computed , Vision, MonocularABSTRACT
The study was carried out to find out predictors of axillary lymph node metastasis in breast cancer and to evaluate its significance in selecting the group of patients in whom axillary dissection could be avoided. Ninety-five breast cancer patients who underwent mastectomy and axillary dissection were included in the study. Factors like patient's age, tumor size, histopathological type, histological grade and estrogen and progesterone receptor status were correlated with the axillary metastases. Out of 95 cases axillary metastasis was found in 47 (49.47%) cases. There was no correlation between patient's age and tumor size with axillary metastasis (p > 0.05). Based on histopathological typing tumors like ductal carcinoma in situ, tubular carcinoma and mucinous carcinoma showed less tendency for axillary metastasis (p < 0.046). Association was found between histological grade and estrogen receptor and progesterone receptor positivity with presence of axillary metastasis (p < 0.001 and 0.002 respectively). The findings in this study indicate that breast cancer patients having favorable histological type, grade I tumors and estrogen and progesterone receptor negative tumor are good candidates to avoid axillary dissection.
ABSTRACT
We report a rare case of ascariasis of gall bladder. The unusual features in this case were the presence of eggs of Ascaris lumbricoides in the lumen. Some of the eggs had evoked a foreign body reaction indicating chronicity. The bladder wall was unevenly thickened with yellowish white nodules and showed maximum thickness around the neck region. Microscopy showed predominantly xanthogranulomatous inflammation in the thickened parts of the wall.
