1.
Biomark Med
; 13(1): 27-31, 2019 01.
Article
in English
| MEDLINE
| ID: mdl-30556735
ABSTRACT
BACKGROUND: Immune thrombocytopenia (ITP) is an acquired disease characterized by various pathogenetic mechanisms. We aimed to evaluate the value of TRAF6 as a biomarker of pathogenesis in ITP. METHODS: 85 newly diagnosed ITP patients and 85 controls were included. RESULTS: In the patient group, mean TRAF6 level was 2348 pg/ml and in the control group, TRAF6 level was 25.57 pg/ml. In corticosteroid-responding patients, TRAF6 levels were lower than nonresponding patients. DISCUSSION: TRAF6 levels were observed to be higher than healthy controls, which suggest a solid relation with ITP pathogenesis. The observation that in patients who present with high TRAF6 levels, there was a significant corticosteroid refractoriness and responsiveness.
Subject(s)
Biomarkers/blood , Immunoglobulins, Intravenous/administration & dosage , Immunologic Factors/administration & dosage , Purpura, Thrombocytopenic, Idiopathic/blood , TNF Receptor-Associated Factor 6/blood , Adult , Aged , Aged, 80 and over , Case-Control Studies , Female , Follow-Up Studies , Humans , Intracellular Signaling Peptides and Proteins , Male , Middle Aged , Prognosis , Prospective Studies , Purpura, Thrombocytopenic, Idiopathic/diagnosis , Purpura, Thrombocytopenic, Idiopathic/drug therapy , Young Adult
2.
J Cancer Res Ther
; 11(4): 1043, 2015.
Article
in English
| MEDLINE
| ID: mdl-26881672