ABSTRACT
BACKGROUND AND OBJECTIVE: To study the effects of dexmedetomidine (DEX) on perioperative blood glucose levels in adult diabetes mellitus (DM) patients undergoing cardiac surgery. METHODS AND MATERIAL: A prospective, observational study was conducted on 100 adult diabetic patients aged between 18 and 75 years undergoing cardiac surgery with cardiopulmonary bypass (CPB). The patients were divided into two groups (group D and group C) of 50 each. Group D patients received DEX infusion, whereas the group C patients received 0.9% normal saline infusion. RESULTS: The blood glucose levels, heart rate, mean arterial pressure, and serum potassium levels at different time points were comparable between the two groups (P > 0.05). The mean dose of insulin required in the combined population as well as in both controlled and uncontrolled DM patients was significantly less in group D than in group C (combined population - 36.03 ± 22.71 vs 47.82 ± 30.19 IU, P = 0.0297; uncontrolled DM - 37.36 ± 23.9 IU vs 48.16 ± 25.15 IU, P = 0.0301; controlled DM - 34.7 ± 21.5 IU vs 47.63 ± 35.25 IU, P = 0.0291). Duration of mechanical ventilation and VIS were comparable between the two groups. The incidence of arrhythmias (20% vs 46%, P = 0.0059) and delirium (6% vs 20%, P = 0.0384) was significantly less in group D than in group C. None of the patients in either group had stroke, myocardial ischemia, and mortality. CONCLUSION: The results suggested that DEX infusion during the intraoperative period was very effective for perioperative glycemic control and reduction of insulin requirement in DM patients undergoing cardiac surgery.
Subject(s)
Blood Glucose , Cardiac Surgical Procedures , Dexmedetomidine , Diabetes Mellitus , Glycemic Control , Humans , Dexmedetomidine/therapeutic use , Male , Female , Middle Aged , Cardiac Surgical Procedures/methods , Prospective Studies , Adult , Blood Glucose/drug effects , Blood Glucose/analysis , Aged , Glycemic Control/methods , Perioperative Care/methods , Young Adult , Adolescent , InsulinABSTRACT
New onset regional wall motion abnormality (RWMA) following coronary artery bypass grafting adversely affects the patient outcome. Early detection and addressing the cause of RWMA improves overall morbidity and mortality of the patient. We report a rare case of early myocardial ischemia detected by intraoperative transesophageal echocardiography due to mechanical compression of a vein graft by a pericardial drain tube.
Subject(s)
Coronary Artery Bypass , Drainage/instrumentation , Echocardiography, Transesophageal/methods , Graft Occlusion, Vascular/diagnostic imaging , Intraoperative Complications/diagnostic imaging , Myocardial Ischemia/diagnostic imaging , Graft Occlusion, Vascular/complications , Graft Occlusion, Vascular/physiopathology , Humans , Intraoperative Complications/etiology , Intraoperative Complications/physiopathology , Male , Middle Aged , Myocardial Ischemia/etiology , Myocardial Ischemia/physiopathology , PericardiumABSTRACT
Iatrogenic valvular regurgitation following cardiac surgery has been reported as a result of leaflet perforation or entrapment. Due to its central location, the aortic valve is one of the most vulnerable structures for iatrogenic injuries. Proper assessment of the aortic valve by transesophageal echocardiography (TEE) should be done after a cardiac surgery in the periaortic area. We hereby report a case of iatrogenic aortic regurgitation which was developed after primary closure of perimembranous ventricular septal defect. It was timely diagnosed by TEE after termination of cardiopulmonary bypass and helped in further management.
