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6.
Vopr Onkol ; 27(5): 10-3, 1981.
Article in Russian | MEDLINE | ID: mdl-6787799

ABSTRACT

A course of combined therapy (adriablastin, cyclophosphan, vincristine and, in some cases, 5-fluorouracil) was given to 50 breast cancer patients with metastases of different localization. Therapy was conducted in 8 day series spaced by 3--4 week intervals; a total of 135 series were administered. Responses of varying degree was registered in 62% of cases. The said combined chemotherapy is highly effective in treatment of metastatic lesions of bones Out of 19 patients, bone reparation was observed in 8 cases (42.1%) and pronounced symptomatic and subjective improvement -- in 13 cases (68.4%). The suggested schedule of therapy has a low toxic effect and may be recommended for integration with medical practice.


Subject(s)
Breast Neoplasms/drug therapy , Doxorubicin/administration & dosage , Cyclophosphamide/administration & dosage , Drug Evaluation , Drug Therapy, Combination , Female , Fluorouracil/administration & dosage , Humans , Neoplasm Metastasis , Neoplasm Recurrence, Local/drug therapy , Thiotepa/administration & dosage , Time Factors , Vincristine/administration & dosage
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