Synthesis and biological activity of some 4-substituted pyrimidines and fused pyrimidines.

The synthesis of 4-beta-cyanoethylthiopyrimidine 2 and 4-chloropyrimidine 8a was chieved from 4-mercapto-5-acetylpyrimidine (1a). Also the synthesis of thienopyrimidine-7,7-dioxide 6, 4-arylaminopyrimidines 9a-e, 4-alkoxypyrimidines 11a, b, pyrimidoquinazoline 10, thienopyrimidines 19a, b and tetrazolopyrimidine 18 was described.