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Matrix Biol ; 20(7): 487-91, 2001 Nov.
Article in English | MEDLINE | ID: mdl-11691588

ABSTRACT

We have identified a novel 14-exon human lysyl oxidase-like gene, LOXL4, on chromosome 10q24. The cDNA and derived amino acid sequence of LOXL4 demonstrates a conserved C-terminal region including the characteristic copper-binding site, lysyl and tyrosyl residues and a cytokine receptor-like domain. One of the four N-terminal SRCR domains contains a 13 amino acid insertion encoded by a short exon not present within the closely homologous LOXL2 and LOXL3 genes. The 3.5-kb LOXL4 mRNA is present in pancreas and testis and at lower levels in several other tissues. Fibroblasts, smooth muscle and osteosarcoma (HOS) cells express LOXL4. No expression was detected in HCT-116 and DLD-1 colon, MCF-7 breast and DU-145 prostate cancer cell lines.


Subject(s)
Amino Acid Oxidoreductases/genetics , Chromosomes, Human, Pair 10 , Cysteine/metabolism , Membrane Proteins , Receptors, Lipoprotein , 3' Untranslated Regions , 5' Untranslated Regions , Amino Acid Oxidoreductases/classification , Amino Acid Oxidoreductases/metabolism , Amino Acid Sequence , Animals , Base Sequence , Binding Sites , Cysteine/genetics , DNA, Complementary , Exons , Humans , Male , Mice , Molecular Sequence Data , Open Reading Frames , Protein Structure, Tertiary , Protein-Lysine 6-Oxidase , Receptors, Immunologic/genetics , Receptors, Immunologic/metabolism , Receptors, Scavenger , Scavenger Receptors, Class B , Tissue Distribution
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