ABSTRACT
Pregnant rats (day 14 of gestation) received intraamniotic injections of newborn human serum. Transfer factors (TF) present in injected serum produced significant embryotoxic and teratogenic effects, as well as changes in coordination of motor activity (EMG) in newborn rats. The extent of embryological disturbances and the motor activity of 33- to 34-day old recipient rats depend on TF concentration (at serum dilution 1:2) and on the state of infant's motor functions ("normal" group and "risk" group). The results obtained allow to objectively determine the pathogenic effect of serum TF on embryotoxicity and formation of motor coordination in the donor infant.
Subject(s)
Embryo, Mammalian/drug effects , Prenatal Exposure Delayed Effects , Transfer Factor/blood , Transfer Factor/toxicity , Abnormalities, Drug-Induced/etiology , Amnion , Animals , Animals, Newborn , Electromyography/drug effects , Embryo Loss/chemically induced , Female , Humans , Infant, Newborn , Injections , Pregnancy , Rats , Transfer Factor/administration & dosageABSTRACT
Breach of locomotor functions and spatially oriented behaviour of rats' cubs after intraamniotic administration of the blood serum of children was shown to depend on the ontogenetic maturity and motor disturbances of donors. Injections were carried out on 14-th day of rats pregnancy.