Disease burden attributable to respiratory syncytial virus outbreaks in long-term care.

Background: Respiratory syncytial virus (RSV) disease burden is significant among children; however, RSV can also cause excess morbidity and mortality among older adults. Populations in long-term care homes (LTCHs) may be at greater risk of exposure and increased infection severity. The objectives of this article are to identify evidence regarding disease burden and outcome severity attributable to RSV outbreaks among residents and staff in LTCHs; and to highlight reported population and outbreak characteristics. Methods: All types of evidence were eligible for inclusion. Data utilized by included studies was between the end of the 2010 H1N1 influenza pandemic and the beginning of the coronavirus disease 2019 (COVID-19) pandemic. Evidence from the following countries was considered: G7, the European Union, Australia and New Zealand. A total of 167 articles were identified; 58 full texts were analyzed and four sources of evidence were eligible for inclusion. Data related to population characteristics, outbreak type and resident and staff outcomes were manually charted. Results: There is a paucity of evidence sources pertaining to RSV outbreak burden among residents and staff in LTCHs. Outbreak duration ranged from 13 to 21 days. For each outbreak, 4-7 residents had confirmed RSV infection. Attack rates ranged from 12% to 38%. A spectrum of disease attributable to RSV outbreaks in LTCHs was identified, ranging from mild cold-like symptoms to death. Conclusion: Integration of RSV into existing respiratory pathogen surveillance programs is important to characterize susceptibility, transmissibility and virulence of RSV in at-risk populations. There is a need for public health organizations to publish the findings from outbreak investigations to provide evidence to inform RSV outbreak prevention and response in LTCH settings.

Epidemiological characteristics of human infections with avian influenza A(H5N6) virus, China and Laos: A multiple case descriptive analysis, February 2014-June 2023.

Background: The first human infection with highly pathogenic avian influenza A(H5N6) virus was reported in 2014. From then until June 30, 2023, 85 human cases with confirmed A(H5N6) infection have been reported worldwide. Objective: To address the present gap in knowledge of the overall epidemiology of human A(H5N6) infections, the epidemiological characteristics of human infection with A(H5N6) in China from February 2014 to June 2023 are described. Methods: Considering the severity of human infections with A(H5N6) virus (case fatality rate: 39%), the increased frequency of case reports from 2021 to present day, and lack of comprehensive epidemiologic analysis of all cases, we conducted a multiple-case descriptive analysis and a literature review to create an epidemiologic profile of reported human cases. Case data was obtained via a literature search and using official intelligence sources captured by the Public Health Agency of Canada's International Monitoring and Assessment Tool (IMAT), including Event Information Site posts from the World Health Organization. Results: Most human A(H5N6) cases have been reported from China (China: 84; Laos: 1), with severe health outcomes, including hospitalization and death, reported among at-risk populations. The majority (84%) of cases reported contact with birds prior to illness onset. Cases were detected throughout the course of the year, with a slight decrease in illness incidence in the warmer months. Conclusion: As A(H5N6) continues to circulate and cause severe illness, surveillance and prompt information sharing is important for creating and implementing effective public health measures to reduce the likelihood of additional human infections.

Multivariate analyses of risk factors associated with laboratory exposure incidents.

Background: Laboratories involved in the study of pathogenic biological agents pose an inherent risk of exposure to the laboratory workforce and the community. Laboratory biosafety and biosecurity activities are fundamental in minimizing the likelihood of unintentional exposure incidents. The objective of this study is to describe the factors that are associated with the occurrence of exposure incidents in a laboratory setting through a predictive model. Methods: The Laboratory Incident Notification Canada is a nationally mandated surveillance system that gathers real-time data from submitted reports of laboratory incidents involving human pathogens and toxins. Data on laboratory exposure incidents were extracted from the system between 2016 and 2020. The occurrence of exposure incidents per month was modelled using a Poisson regression with several potential risk factors, including seasonality, sector, occurrence type, root causes, role and education of people exposed and years of laboratory experience. A stepwise selection method was used to develop a parsimonious model with consideration of the significant risk factors identified in the literature. Results: After controlling for other variables in the model, it was found that 1) for each human interaction related root cause, the monthly number of exposure incidents was expected to be 1.11 times higher compared to the number of incidents without human interaction (p=0.0017) as a root cause and 2) for each standard operating procedure-related root cause, the monthly number of exposure incidents was expected to be 1.13 times higher compared to the number of incidents without a standard operating procedure related root cause (p=0.0010). Conclusion: Laboratory biosafety and biosecurity activities should target these risk factors to reduce the occurrence of exposure incidents. Qualitative studies are needed to provide better reasoning for the association of these risk factors with the occurrence of exposure incidents.

Rapid review of multisystem inflammatory syndrome in paediatrics: What we know one year later.

BACKGROUND: : Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19) is an emerging condition that was first identified in paediatrics at the onset of the COVID-19 pandemic. The condition is also known as pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (PIMS-TS or PIMS), and multiple definitions have been established for this condition that share overlapping features with Kawasaki Disease and toxic shock syndrome. METHODS: : A review was conducted to identify literature describing the epidemiology of MIS-C, published up until March 9, 2021. A database established at the Public Health Agency of Canada with COVID-19 literature was searched for articles referencing MIS-C, PIMS or Kawasaki Disease in relation to COVID-19. RESULTS: : A total of 195 out of 988 articles were included in the review. The median age of MIS-C patients was between seven and 10 years of age, although children of all ages (and adults) can be affected. Multisystem inflammatory syndrome in children disproportionately affected males (58% patients), and Black and Hispanic children seem to be at an elevated risk for developing MIS-C. Roughly 62% of MIS-C patients required admission to an intensive care unit, with one in five patients requiring mechanical ventilation. Between 0% and 2% of MIS-C patients died, depending on the population and available interventions. CONCLUSION: : Multisystem inflammatory syndrome in children can affect children of all ages. A significant proportion of patients required intensive care unit and mechanical ventilation and 0%-2% of cases resulted in fatalities. More evidence is needed on the role of race, ethnicity and comorbidities in the development of MIS-C.

Surveillance of laboratory exposures to human pathogens and toxins, Canada 2020.

BACKGROUND: The Laboratory Incident Notification Canada surveillance system monitors laboratory incidents reported under the Human Pathogens and Toxins Act and the Human Pathogens and Toxins Regulations. The objective of this report is to describe laboratory exposures that were reported in Canada in 2020 and the individuals who were affected. METHODS: Laboratory incident exposures occurring in licensed Canadian laboratories in 2020 were analyzed. The exposure incident rate was calculated and the descriptive statistics were performed. Exposure incidents were analyzed by sector, activity type, occurrence type, root cause and pathogen/toxin. Affected persons were analyzed by education, route of exposure sector, role and laboratory experience. The time between the incident and the reporting date was also analyzed. RESULTS: Forty-two incidents involving 57 individuals were reported to Laboratory Incident Notification Canada in 2020. There were no suspected or confirmed laboratory acquired infections. The annual incident exposure rate was 4.2 incidents per 100 active licenses. Most exposure incidents occurred during microbiology activities (n=22, 52.4%) and/or were reported by the hospital sector (n=19, 45.2%). Procedural issues (n=16, 27.1%) and sharps-related incidents (n=13, 22.0%) were the most common occurrences. Most affected individuals were exposed via inhalation (n=28, 49.1%) and worked as technicians or technologists (n=36, 63.2%). Issues with standard operating procedures was the most common root cause (n=24, 27.0%), followed by human interactions (n=21, 23.6%). The median number of days between the incident and the reporting date was six days. CONCLUSION: The rate of laboratory incidents were lower in 2020 than 2019, although the ongoing pandemic may have contributed to this decrease because of the closure of non-essential workplaces, including laboratories, for a portion of the year. The most common occurrence type was procedural while issues with not complying to standard operating procedures and human interactions as the most cited root causes.

COVID-19: A case for the collection of race data in Canada and abroad.

Racialized populations have consistently been shown to have poorer health outcomes worldwide. This pattern has become even more prominent in the wake of the coronavirus disease 2019 (COVID-19) pandemic. In countries where race disaggregated data are routinely collected, such as the United States and the United Kingdom, preliminary reports have identified that racialized populations are at a heightened risk of COVID-19 infection and mortality. Similar patterns are emerging in Canada but rely on proxy measures such as neighbourhood diversity to account for race, in the absence of person-level data. It follows that the collection of race disaggregated data in Canada is a crucial element in identifying individuals at risk of poorer COVID-19 outcomes and developing targeted public health interventions to mitigate risk among Canada's racialized populations. Given this continuing gap, advocating for timely access to this data is of great importance owing to the challenges that the COVID-19 pandemic has highlighted amongst racialized populations in Canada and worldwide.

Epidemiologic and clinical characteristics of multisystem inflammatory syndrome in adults: a rapid review.

Multisystem inflammatory disease in children (MIS-C) is one of the severe presentations of the coronavirus disease 2019 (COVID-19) that has been described in the literature since the beginning of the pandemic. Although MIS-C refers to children, cases with similar clinical characteristics have been recently described in adults. A description of the epidemiologic and clinical characteristics of multisystem inflammatory disease in adults (MIS-A) is a starting point for better knowledge and understanding of this emerging disease. We identified nine case reports of MIS-A in the literature, five from the United States, two from France and two from the United Kingdom. The case descriptions revealed similarities in clinical features, including occurrence during post-acute disease phase, fever, digestive symptoms, cardiac involvement and elevated inflammatory markers. All the patients were hospitalized, three required admission to the intensive care unit and one died. The most common treatments were intravenous immunoglobulin, prednisolone and aspirin. These findings suggest that MIS-A is a severe complication of COVID-19 disease that can lead to death. Further studies to improve our understanding of the pathogenesis of MIS-A, which will help improve treatment decisions and prevent sequelae or death.

Serum antibody response in COVID-19-recovered patients who retested positive.

BACKGROUND: Research studies comparing antibody response from coronavirus disease 2019 (COVID-19) cases that retested positive (RP) using reverse transcription polymerase chain reaction (RT-PCR) and those who did not retest positive (NRP) were used to investigate a possible relationship between antibody response and retesting status. METHODS: Seven data bases were searched. Research criteria included cohort and case-control studies, carried out worldwide and published before September 9, 2020, that compared the serum antibody levels of hospitalized COVID-19 cases that RP after discharge to those that did NRP. RESULTS: There is some evidence that immunoglobulin G (IgG) and immunoglobulin M (IgM) antibody levels in RP cases were lower compared with NRP cases. The hypothesis of incomplete clearance aligns with these findings. The possibility of false negative reverse transcription polymerase chain reaction (RT-PCR test results during viral clearance is also plausible, as concentration of the viral ribonucleic acid (RNA) in nasopharyngeal and fecal swabs fluctuate below the limits of RT-PCR detection during virus clearance. The probability of reinfection was less likely to be the cause of retesting positive because of the low risk of exposure where cases observed a 14 day-quarantine after discharge. CONCLUSION: More studies are needed to better explain the immune response of recovered COVID-19 cases retesting positive after discharge.

Impact of school closures and re-openings on COVID-19 transmission.

BACKGROUND: Globally, the education of students at primary and secondary schools has been severely disrupted by the implementation of school closures to reduce the spread of coronavirus disease 2019 (COVID-19). The effectiveness of school closures in reducing transmission of COVID-19 and the impact of re-opening schools are unclear. METHODS: Research criteria for this rapid review included empirical studies, published or pre-published worldwide before January 25, 2021, that assessed the effectiveness of school closures in reducing the spread of COVID-19 and the impact of school re-openings on COVID-19 transmission. RESULTS: Twenty-four studies on the impact of school closures and re-openings on COVID-19 transmission were identified through the seven databases that were searched. Overall the evidence from these studies was mixed and varied due to several factors such as the time of implementation of public health measures, research design of included studies and variability among the levels of schooling examined. CONCLUSION: Preliminary findings suggest that school closures have limited impact on reducing COVID-19 transmission, with other non-pharmaceutical interventions considered much more effective. However, due to the limitations of the studies, further research is needed to support the use of this public health measure in response to the COVID-19 pandemic.

Effets projetés des mesures de santé publique non pharmacologiques visant à prévenir la recrudescence de la transmission du SRAS-CoV-2 au Canada.

CONTEXTE: Il faudra prendre des mesures continues contre la transmission communautaire du coronavirus du syndrome respiratoire aigu sévère 2 (SRAS-CoV-2) pour prévenir d'autres vagues d'infection. Nous avons exploré les effets des interventions non pharmacologiques sur la transmission projetée du SRAS-CoV-2 au Canada. MÉTHODES: Nous avons créé un modèle de la population canadienne à base d'agents intégrant l'âge qui simule les effets des mesures de santé publique, selon leur intensité actuelle et projetée, sur la transmission du SRAS-CoV-2. Les mesures étudiées sont le dépistage et l'isolement des cas, la recherche de contacts et la mise en quarantaine, l'éloignement sanitaire et la fermeture des espaces partagés. Nous avons évalué l'effet des mesures prises individuellement et celui des mesures combinées. RÉSULTATS: En l'absence de mesures, 64,6 % (intervalle de crédibilité [ICr] à 95 % : 63,9 %­65,0 %) des Canadiens contracteraient le SRAS-CoV-2 (taux d'attaque global), et 3,6 % (ICr à 95 % 2,4 %­3,8 %) des personnes infectées en mourraient. En poursuivant le dépistage et la recherche de contacts à la même intensité que pendant la période de référence, sans maintenir l'éloignement sanitaire ou refermer certains endroits, le pays connaîtrait un taux d'attaque global de 56,1 % (ICr à 95 % 0,05 %­57,1 %); si ces mesures étaient accrues, le taux d'attaque chuterait à 0,4 % (ICr à 95 % 0,03 %­23,5 %). En combinant ce dernier scénario et le maintien de l'éloignement sanitaire, le taux tomberait à 0,2 % (ICr à 95 % 0,03 %­1,7 %). Ce scénario est le seul qui garderait la demande en soins hospitaliers et intensifs sous la capacité, qui préviendrait presque tous les décès et qui mettrait fin à l'épidémie. La prolongation de la fermeture des écoles aurait un effet minime, mais réduirait la transmission en milieu scolaire. Par contre, la prolongation de la fermeture des lieux de travail et des lieux publics réduirait de manière marquée le taux d'attaque et mettait habituellement ou toujours fin à l'épidémie, selon les différents scénarios simulés. INTERPRÉTATION: Le contrôle de la transmission du SRAS-CoV-2 passera par l'amélioration et le maintien des mesures, tant communautaires qu'individuelles. Autrement, il y aura une recrudescence de l'épidémie, et un risque de surcharger le système de santé.

Assessing the progression of the COVID-19 pandemic in Canada using testing data and time-dependent reproduction numbers.

OBJECTIVES: To compare a mathematical tool and time-dependent reproduction number (Rt) estimates to assess the COVID-19 pandemic progression in a Canadian context. METHODS: Total number of reported cases were plotted against total number of tests for COVID-19 performed over time, with and without smoothing, for Canada and some Canadian provinces individually. Changes in curvature profile were identified as either convex or concave as indicators of pandemic acceleration or deceleration, respectively. Rt estimates were calculated on an exponential growth rate. RESULTS: For Canada as a whole, the testing graphs had a slightly concave profile and a coincident decrease in Rt estimates. Saskatchewan more recently had a convex profile with a gradual shift to a concave profile and also demonstrated a gradual decline in Rt estimates. Curves and Rt estimates for Alberta, British Columbia, Manitoba, Nova Scotia, Ontario and Quebec displayed a gradual shift towards concavity over time and an overall decrease in Rt estimates, which is suggestive of a positive impact of public health interventions implemented federally and provincially. CONCLUSION: The present analyses compared a mathematical tool to Rt estimates to ascertain the status of the pandemic in Canada. Caution should be taken when interpreting results due to factors such as varying testing protocols, available testing data unique to each province and limitations inherent to each method, which may generate different results using the two approaches. Analysis of testing data may complement metrics obtained from surveillance data to allow for a weight-of-evidence approach to assess the status of the COVID-19 pandemic.

RéSUMé: OBJECTIFS: Comparer un outil mathématique aux estimations du taux de reproduction en fonction du temps (Rt) pour évaluer la progression de la pandémie de la COVID-19 dans le contexte canadien. MéTHODES: Le nombre total de cas signalés a été comparé au nombre total de tests à la COVID-19 effectués au fil du temps, avec et sans lissage, pour le Canada et certaines provinces canadiennes individuellement. Les modifications du profil de courbure identifiées comme étant convexes ou concaves seraient des indicateurs respectivement d'une accélération ou d'une décélération de la pandémie. Le calcul des estimations du Rt a été réalisé en fonction du taux de croissance exponentiel. RéSULTATS: Pour l'ensemble du Canada, la légère concavité des graphiques relatifs aux tests coïncidait avec la diminution des estimations du Rt. Plus récemment, la Saskatchewan avait un profil convexe avec un passage progressif à un profil concave et a également démontré une baisse progressive des estimations du Rt. Les courbes et les estimations du Rt pour l'Alberta, la Colombie-Britannique, le Manitoba, la Nouvelle-Écosse, l'Ontario et le Québec ont montré un glissement progressif vers la concavité au fil du temps et une diminution globale des estimations du Rt, ce qui suggère un impact positif des interventions de santé publique mises en œuvre au niveau fédéral et provincial. CONCLUSION: Les présentes analyses ont comparé un outil mathématique aux estimations de Rt pour déterminer l'état de la pandémie au Canada. Les résultats doivent être interprétés avec prudence en raison de certains facteurs tels que les différences entre provinces en ce qui concerne les protocoles de réalisation des tests et la disponibilité des données relatives aux tests. De plus, une limite inhérente à la méthodologie de cette étude est la possibilité d'obtenir des résultats différents en fonction de l'approche utilisée. L'analyse des données des tests pourrait être complémentaire à celle des données de surveillance pour permettre une approche fondée sur le poids de la preuve dans le cadre de l'évaluation de l'état de la pandémie de la COVID-19.

Projected effects of nonpharmaceutical public health interventions to prevent resurgence of SARS-CoV-2 transmission in Canada.

BACKGROUND: Continual efforts to eliminate community transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will be needed to prevent additional waves of infection. We explored the impact of nonpharmaceutical interventions on projected SARS-CoV-2 transmission in Canada. METHODS: We developed an age-structured agent-based model of the Canadian population simulating the impact of current and projected levels of public health interventions on SARS-CoV-2 transmission. Interventions included case detection and isolation, contact tracing and quarantine, physical distancing and community closures, evaluated alone and in combination. RESULTS: Without any interventions, 64.6% (95% credible interval [CrI] 63.9%-65.0%) of Canadians will be infected with SARS-CoV-2 (total attack rate) and 3.6% (95% CrI 2.4%-3.8%) of those infected and symptomatic will die. If case detection and contact tracing continued at baseline levels without maintained physical distancing and reimplementation of restrictive measures, this combination brought the total attack rate to 56.1% (95% CrI 0.05%-57.1%), but it dropped to 0.4% (95% CrI 0.03%-23.5%) with enhanced case detection and contact tracing. Combining the latter scenario with maintained physical distancing reduced the total attack rate to 0.2% (95% CrI 0.03%-1.7%) and was the only scenario that consistently kept hospital and intensive care unit bed use under capacity, prevented nearly all deaths and eliminated the epidemic. Extending school closures had minimal effects but did reduce transmission in schools; however, extending closures of workplaces and mixed-age venues markedly reduced attack rates and usually or always eliminated the epidemic under any scenario. INTERPRETATION: Controlling SARS-CoV-2 transmission will depend on enhancing and maintaining interventions at both the community and individual levels. Without such interventions, a resurgent epidemic will occur, with the risk of overwhelming our health care systems.

Factors associated with the healthcare-seeking behaviour of older people in Nigeria.

This study aimed to examine the factors associated with healthcare-seeking behaviour of Nigeria's older adult population. Data were retrieved from the Nigeria General Household Survey (GHS - year 2013) database, representative at the national level. Bivariate analysis and Poisson regression were performed. Among 3587 adults aged 50 years and over, 850 reported having been sick in the previous four weeks, and 53% of those had consulted a health practitioner in that period. Those consulting were more likely to be women (PR = 1.30, 95% CI [1.1-1.15]), older than 65 (PR = 1.25, 95% CI [1.1-1.5]), and unemployed (PR = 1.24, 95% CI [1.0-1.4]), whereas lack of education (PR = 0.73, 95% CI [0.6 0-0.8]), low household income (PR = 0.72, 95% CI [0.5-0.9]) and living in the South East (PR = 0.59 95% CI [0.4-0.7]) and in the South South zones (PR = 0.60 95% CI [0.4-0.7]) were associated with lower consultation rates. Our results suggest that improving older adults' healthcare-seeking behaviour in Nigeria will require the lifting of financial barriers and improvements to education. More studies are needed to better understand geographic differences and the low consultation rate by men.

Characterisation of the rural indigent population in Burkina Faso: a screening tool for setting priority healthcare services in sub-Saharan Africa.

BACKGROUND: In Africa, health research on indigent people has focused on how to target them for services, but little research has been conducted to identify the social groups that compose indigence. Our aim was to identify what makes someone indigent beyond being recognised by the community as needing a card for free healthcare. METHODS: We used data from a survey conducted to evaluate a state-led intervention for performance-based financing of health services in two districts of Burkina Faso. In 2015, we analysed data of 1783 non-indigents and 829 people defined as indigents by their community in 21 villages following community-based targeting processes. Using a classification tree, we built a model to select socioeconomic and health characteristics that were likely to distinguish between non-indigents and indigents. We described the screening performance of the tree using data from specific nodes. RESULTS: Widow(er)s under 45 years of age, unmarried people aged 45 years and over, and married women aged 60 years and over were more likely to be identified as indigents by their community. Simple rules based on age, marital status and gender detected indigents with sensitivity of 75.6% and specificity of 55% among those 45 years and over; among those under 45, sensitivity was 85.5% and specificity 92.2%. For both tests combined, sensitivity was 78% and specificity 81%. CONCLUSION: In moving towards universal health coverage, Burkina Faso should extend free access to priority healthcare services to widow(er)s under 45, unmarried people aged 45 years and over, and married women aged 60 years and over, and services should be adapted to their health needs. ETHICS CONSIDERATIONS: The collection, storage and release of data for research purposes were authorised by a government ethics committee in Burkina Faso (Decision No. 2013-7-066). Respondent consent was obtained verbally.

User fees exemptions alone are not enough to increase indigent use of healthcare services.

The aim of this study was to assess whether user fees exemptions increased healthcare services use among indigents in the Ouargaye district in Burkina Faso. In this pre-post study, we surveyed 1224 indigents in 2010 about their healthcare services use over the preceding 6 months. Of these, 540 subsequently received a user fees exemption card. A follow-up survey was conducted 1 year later with a 55.3% retention rate. Analyses were performed in accordance with Andersen and Newman's model (Societal and individual determinants of medical care utilization in the United States. Milbank Q 1973;51:95-124) to explain healthcare services use by considering predisposing and facilitating factors and health needs indicators. Logistic regression analyses were performed.Among indigents exempted from user fees, 46.2% increased their healthcare services use in 2011, as opposed to 42.1% among the non-exempted. Being exempted was not associated with increased use of services (odds ratio, OR = 1.1, 95% confidence interval, CI [0.80-1.51]). Regardless of whether they were exempted or not, the indigents most likely to have increased their healthcare services use were older than 69 years of age (OR = 1.66, 95% CI [1.05-2.64]), male (OR = 1.44, 95% CI [0.99-2.08]), in low-income households (OR = 1.71, 95% CI [1.15-2.54]), and had received financial support from their families to obtain healthcare (OR = 1.59, 95% CI [1.1-2.28]). The indigents' increased healthcare services use was not attributable to user fees exemptions. Some contamination of the intervention is conceivable. Interventions combining user fees exemptions with actions targeting other obstacles to healthcare access would probably be more effective in increasing indigents' use of healthcare centres.

Is the process for selecting indigents to receive free care in Burkina Faso equitable?

BACKGROUND: In Burkina Faso, patients are required to pay for healthcare. This constitutes a barrier to access for indigents, who are the most disadvantaged. User fee exemption systems have been created to facilitate their access. A community-based initiative was thus implemented in a rural region of Burkina Faso to select the worst-off and exempt them from user fees. The final selection was not based on pre-defined criteria, but rather on community members' tacit knowledge of the villagers. The objective of this study was to analyze the equitable nature of this community-based selection process. METHOD: Based on a cross-sectional study carried out in 2010, we surveyed 1,687 indigents. The variables collected were those that determine healthcare use according to the Andersen-Newman model (1969): sociodemographic variables; income; occupation; access to financial, food or instrumental assistance; presence of chronic illness; and disabilities related to vision, muscle strength, or mobility. Bivariate analyses and logistic regression were performed. RESULTS: User fee exemptions were given mainly to indigents who were widowed (OR = 1.40; CI 95% [1.10-1.78]), had no financial assistance from their household for healthcare (OR = 1.58; CI 95% [1.26-1.97], lived alone (OR = 1.28; CI 95% [1.01-1.63]), lived with their spouses, (OR = 2.00; CI 95% [1.35-2.96], had vision impairments (OR = 1.45; CI 95% [1.14-1.84]), or had poor muscle strength and good mobility (OR = 1.73; CI 95% [1.28-2.33]). The indigent selection was not determined by household income, self-reported chronic illness, or previous use of services. CONCLUSION: The community selection process took into account factors related to social vulnerability and functional limitations. However, we cannot affirm that the selection process was perfectly equitable, as it was very restrictive due to the limited budget available and the State's lack of engagement in this matter. Exemption processes should be temporary solutions, and the State should make a commitment to move toward universal healthcare coverage.

Gender differences in cognitive impairment and mobility disability in old age: a cross-sectional study in Ouagadougou, Burkina Faso.

This study aims to examine differences in cognitive impairment and mobility disability between older men and women in Ouagadougou, Burkina Faso, and to assess the extent to which these differences could be attributable to gender inequalities in life course social and health conditions. Data were collected on 981 men and women aged 50 and older in a 2010 cross-sectional health survey conducted in the Ouagadougou Health and Demographic Surveillance System. Cognitive impairment was assessed using the Leganés cognitive test. Mobility disability was self-reported as having any difficulty walking 400 m without assistance. We used logistic regression to assess gender differences in cognitive impairment and mobility disability. Prevalence of cognitive impairment was 27.6% in women and 7.7% in men, and mobility disability was present in 51.7% of women and 26.5% of men. The women to men odds ratio (95% confidence interval) for cognitive impairment and mobility disability was 3.52 (1.98-6.28) and 3.79 (2.47-5.85), respectively, after adjusting for the observed life course social and health conditions. The female excess was only partially explained by gender inequalities in nutritional status, marital status and, to a lesser extent, education. Among men and women, age, childhood hunger, lack of education, absence of a partner and being underweight were independent risk factors for cognitive impairment, while age, childhood poor health, food insecurity and being overweight were risk factors for mobility disability. Enhancing nutritional status and education opportunities throughout life span could prevent cognitive impairment and mobility disability and partly reduce the female excess in these disabilities.

Combining user fees exemption with training and supervision helps to maintain the quality of drug prescriptions in Burkina Faso.

To improve access to health care services, an intervention was implemented in Burkina Faso granting full exemption from user fees. Two further components, staff training and supervision, were added to support the intervention. Our aim in this study was to examine how this tripartite intervention affected the quality of drug prescriptions. Using a mixed methodology, we first conducted an interrupted time series over 24 months. Nine health centres were studied that had previously undergone a process analysis. A total of 14 956 prescriptions for children 0-4 years old were selected by interval sampling from the visit registries from 1 year before to 1 year after the intervention's launch. We then interviewed 14 prescribers. We used three World Health Organization (WHO) indicators to assess drug prescription quality. Analysis was carried out using linear regression and logistic regression. The prescribers' statements underwent content analysis, to understand their perceptions and changes in their practice since the subsidy's introduction. One effect of the intervention was a reduced use of injections (odd ratio (OR) = 0.28 [0.17; 0.46]) in cases of acute lower respiratory tract infections (ALRTI) without comorbidity. Another was a reduction in the inappropriate use of antibiotics in malaria without comorbidity (OR = 0.48 [0.33; 0.70]). The average number of drugs prescribed also decreased (coefficient = -0.14 [-0.20; -0.08]) in cases of ALRTI without comorbidity. The prescribers reported that their practices were either maintained or improved. The user fees exemption programme, combined with health staff training and supervision, did not lead to any deterioration in the quality of drug prescriptions.