Subject(s)
Hemangioma/pathology , Skin Neoplasms/pathology , Adolescent , Hemangioma/congenital , Humans , Leg , Male , Skin Neoplasms/congenitalABSTRACT
This case has been presented as pellagra, which is very rare in children. Pellagra is due dietary deficiency of niacin. Usually seen in alcoholics, malabsorption syndromes occur very rarely in children. A 11-y-old girl presented with well-defined, hyperpigmented, hyperkeratotic, symmetrical, thick scaly plaques surrounded by erythema on the dorsum of the hands, arms, feet, legs up to knees, and along the sides of the neck. The child was given 100 mg of Nicotinamide. Skin lesions resolved rapidly with the treatment and the child improved.
Subject(s)
Niacin/deficiency , Pellagra/diagnosis , Pellagra/drug therapy , Child , Erythema/physiopathology , Female , Humans , Malabsorption Syndromes/complications , Malabsorption Syndromes/drug therapy , Niacinamide/therapeutic use , Pellagra/complications , Skin Diseases/diagnosis , Skin Diseases/drug therapy , Skin Diseases/etiologySubject(s)
Leprosy, Borderline/pathology , Leprosy, Tuberculoid/pathology , Psoriasis/pathology , Adult , Humans , Leprosy, Borderline/complications , Leprosy, Borderline/drug therapy , Leprosy, Tuberculoid/complications , Leprosy, Tuberculoid/drug therapy , Male , Psoriasis/complications , Psoriasis/drug therapyABSTRACT
OBJECTIVE: Cutaneous drug reactions are the most common type of adverse drug reactions. Adverse cutaneous drug reactions form 2-3% of the hospitalized patients. 2% of these are potentially serious. This study aims to detect the drugs commonly implicated in Steven Johnson Syndrome-Toxic Epidermal Necrosis (SJS-TEN). MATERIALS AND METHODS: A retrospective analysis was done in all patients admitted in the last five years in SDM hospital with the diagnosis of SJS-TEN. RESULTS: A total of 22 patients with SJS-TEN were studied. In 11 patients anti-epileptics was the causal drug and in 7, anti-microbials was the causal drug. Recovery was much faster in case of anti epileptics induced SJS-TEN as compared to that induced by ofloxacin. CONCLUSION: SJS-TEN induced by ofloxacin has a higher morbidity and mortality compared to anti convulsants.
Subject(s)
Anti-Bacterial Agents/adverse effects , Anticonvulsants/adverse effects , Ofloxacin/adverse effects , Stevens-Johnson Syndrome/chemically induced , Stevens-Johnson Syndrome/etiology , Adolescent , Adult , Aged , Aged, 80 and over , Child , Child, Preschool , Female , Humans , India , Infant , Male , Middle Aged , Retrospective Studies , Young AdultABSTRACT
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a rare and life-threatening delayed drug hypersensitivity reaction characterized by skin eruption, fever, lymphadenopathies, and visceral involvement. Here, we are presenting a 12 year old boy, who developed rare but life threatening DRESS syndrome due to Lamotrigine. Early detection and treatment led to his rapid recovery. This case is presented to highlight the importance of early detection of rare fatal syndrome.
Subject(s)
Anticonvulsants/adverse effects , Drug Hypersensitivity/etiology , Eosinophilia/chemically induced , Hypersensitivity, Delayed/chemically induced , Triazines/adverse effects , Child , Humans , Lamotrigine , Male , SyndromeABSTRACT
Fixed drug eruption (FDE) is mainly characterized by skin lesions that recur at the same anatomic sites upon repeated exposures to an offending agent. It represents the most common cutaneous adverse drug reaction pattern in Indian patients. Here, we report an FDE to fluconazole.
