ABSTRACT
A 69-year-old man presented with a 2.4 cm painless mass in his right testis. Inguinal orchiectomy was performed. Histologically a carcinoid tumor of the testis was diagnosed. These neuroendocrine, noninvasive tumors are very rare, representing 0.23% of all testicular neoplasms. In 10% these tumors are associated with carcinoid syndrome and in 20% with metastatic disease.
Subject(s)
Carcinoid Tumor/diagnosis , Testicular Neoplasms/diagnosis , Aged , Diagnosis, Differential , Humans , MaleABSTRACT
Cysts of the esophagus are rare mediastinal tumors presenting a large variety of clinical symptoms. Even with modern methods of examination an exact diagnosis is difficult to obtain and often only possible after histological examination. Complications are perforation, or pulmonary, thoracic or esophageal haemorrhage. First choice of therapy is the exstirpation. We report on a 50 year old man with backache and the initial diagnosis of renal colic. Only the magnetic resonance image showed an isolated mediastinal esophageal cyst as the reason. The cyst was removed by thoracotomy. The operation and treatment were without complications. Symptomatology, diagnostical pitfalls and the therapy are described.
Subject(s)
Back Pain/etiology , Esophageal Diseases/diagnosis , Mediastinal Cyst/diagnosis , Diagnosis, Differential , Esophageal Diseases/surgery , Esophagus/pathology , Esophagus/surgery , Humans , Magnetic Resonance Imaging , Male , Mediastinal Cyst/surgery , Middle AgedABSTRACT
The release of prostanoids from rat brain, gastric mucosa, lungs and kidneys incubated ex vivo has been investigated for up to 5 h after oral administration of 10 mg/kg lysine clonixinate or 1 mg/kg ketorolac tromethamine. Additionally, 60 min after drug administration, a time point of near-maximal inhibition of prostanoid release, the effects of 2.5, 10 and 30 mg/kg lysine clonixinate and of 0.0225, 0.15 and 1 mg/kg ketorolac tromethamine were compared. In all organs investigated both drugs inhibited fatty acid cyclooxygenase (COX) in a dose-dependent manner, but ketorolac tromethamine was more potent and had a longer-lasting effect than lysine clonixinate. While the ID50 values for lysine clonixinate were in the same order of magnitude for all 4 organs investigated, ketorolac tromethamine exhibited some organ selectivity with a particularly high activity in the kidneys. This effect might be related to the renal toxicity of ketorolac tromethamine. On the other hand, the difference in potency was smallest in brain suggesting that inhibition of central prostanoid biosynthesis could contribute to the rapid and effective inhibition of pain by both drugs. IC50 values for inhibition of purified COX-1 and COX-2 in vitro were slightly lower for lysine clonixinate (2.4 and 24.6 micrograms/ml, respectively) than for ketorolac tromethamine (3.7 and 25.6 micrograms/ml, respectively).
Subject(s)
Analgesics/pharmacology , Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Brain/drug effects , Brain/metabolism , Clonixin/analogs & derivatives , Cyclooxygenase Inhibitors/pharmacology , Gastric Mucosa/drug effects , Gastric Mucosa/metabolism , Kidney/drug effects , Kidney/metabolism , Lung/drug effects , Lung/metabolism , Lysine/analogs & derivatives , Prostaglandins/metabolism , Tolmetin/analogs & derivatives , Tromethamine/pharmacology , 6-Ketoprostaglandin F1 alpha/biosynthesis , 6-Ketoprostaglandin F1 alpha/metabolism , Administration, Oral , Animals , Clonixin/pharmacology , Dinoprost/biosynthesis , Dinoprost/metabolism , Dose-Response Relationship, Drug , Drug Combinations , Indomethacin/pharmacology , Isoenzymes/antagonists & inhibitors , Isoenzymes/metabolism , Ketorolac Tromethamine , Lysine/pharmacology , Male , Prostaglandin-Endoperoxide Synthases/metabolism , Prostaglandins/biosynthesis , Rats , Rats, Wistar , Thromboxane B2/biosynthesis , Thromboxane B2/metabolism , Tolmetin/pharmacologyABSTRACT
Natural Dermatophilus congolensis infection is found in many species of livestock and wild animals. It is, however, rarely described in camels and there are no details of bacterial isolation. In an investigation of both arid and semi-arid areas in Kenya, an outbreak of dermatophilosis was observed in camel calves being reared on a commercial farm in a semi-arid area. Histopathology and bacterial isolation were used to diagnose the diseases. The potential impact of the disease in camels is discussed.
