Evaluation of a pilot regimen for postoperative pain control in patients receiving oral morphine pre-operatively.

Postoperative analgesia in patients who receive regular oral opioids pre-operatively is frequently suboptimal. To improve management we introduced a regimen using subcutaneous diamorphine infusions with incremental doses. Infusion doses were calculated as half the daily pre-operative dose of oral morphine with the increments as one-sixth of the infusion dose. Results were recorded on the first two postoperative days before (n = 13) and after (n = 23) commencing the new regimen. The percentage of patients reporting severe pain at rest and on movement were significantly reduced by the new regimen (54% and 69% vs. 13% and 40%, respectively) since the opioid dose as a percentage of the pre-operative dose was significantly higher (160% vs. 352%). There were no instances of excessive sedation or slow respiratory rate in any patient. The use of the regimen has resulted in greater doses of opioids being administered with fewer patients in severe pain without significant complications.

Bleeding complications with enoxaparin for deep venous thrombosis prophylaxis.

The safest and most efficacious method of deep venous thrombosis prophylaxis remains controversial. With the use of enoxaparin, a low-molecular-weight heparin, becoming ubiquitous in many institutions, we specifically examined bleeding complications related to its use. A case-control study was conducted on consecutive patients receiving enoxaparin prophylaxis after primary or revision total knee or total hip arthroplasty or hip hemiarthroplasty. Matched controls receiving no pharmacologic anticoagulation were identified. Patient and operative characteristics, hematologic values, and timing of enoxaparin dosing were analyzed as related to major and minor bleeding complications. A total of 152 procedures with enoxaparin and an equal number of control cases were included for a total of 304 patients. The enoxaparin group had a 23.7% total complication rate compared to 16.5% for the control group (P = .11). The power of the test was .35 and indicated that approximately 970 patients would need to be reviewed to have at least an 80% chance of finding a statistically significant difference. Major complications occurred in 5 patients (3.3%) in the enoxaparin group and 2 (1.3%) in the control group (P = .25, power = .21). Minor complications in the enoxaparin group were slightly higher but not significant at 20.4% versus 15.1% in the control group (P = .23). There were significantly fewer minor complications in the enoxaparin group after primary single-joint procedures (16.50%) than all other procedures (32.4%). Patients receiving the first dose of enoxaparin 10 hours or more postoperatively had significantly fewer complications (P = .05). The postoperative hematocrit drop was significantly greater for the enoxaparin group for all procedures (P = .003) as well as for primary single procedures (P = .0005). The postoperative transfusion requirement was significantly greater after primary single procedures (P = .02) in the enoxaparin group. One patient with an epidural catheter and receiving enoxaparin postoperatively developed an epidural hematoma. Although there were not significantly more complications with enoxaparin, there was evidence of significantly increased postoperative bleeding. The low-power analysis reveals that a large number of patients (970-1,700) are required to show a statistically significant difference in bleeding complications between the 2 groups. To minimize complications, a short period to allow initial hemiostasis postoperatively is recommended, as is preferential use of enoxaparin for primary single-joint replacements. Enoxaparin used in conjunction with an indwelling epidural catheter is not recommended.

Continuous axillary brachial plexus blockade for reflex sympathetic dystrophy.

Reflex sympathetic dystrophy is one of the commoner neurogenic pain syndromes; the typical onset follows peripheral trauma and is characterised by diffuse burning pain and hyperalgesia, accompanied by variable vasomotor and dystrophic changes. Successful treatment of an established reflex sympathetic dystrophy may be difficult. A case is reported describing the successful use of a series of continuous axillary brachial plexus blocks for the treatment of this syndrome.

Survey of health promotion organisational arrangements and levels of service for health promotion.

This study was promoted by the Executive Committee of the Association of Directors of Public Health when faced with the need to examine the organisation of and quantify health promotion arrangements in the Health Districts of England and Wales, resulting from the concerns of many of the members of the Association. These concerns were based on the views that health promotion is a key purchasing function of the District Health Authorities and must be appropriately and effectively structured and adequately resourced if the requirements of The Health of The Nation are to be fulfilled. There are many aspects to health promotion work and the delivery of health promotion services which will need addressing in the new commissioning environment of the NHS. A need was recognised for up-to-date data about health promotion services to inform a necessary debate about future arrangements, since it appeared that organisational change was being driven by influences unconnected with the possibly most appropriate structure of health promotion departments and which relate to a contemporary view of health promotion. Reducing the size and cutting the cost of commissioning authorities was perceived as one of the most important influences. A postal questionnaire survey to all Health District and Regional Health Authorities in England and Wales was conducted covering questions about the present organisational arrangements and levels of service, and soliciting the opinions of those canvassed. A total of 185 District and Regional Health Authorities, effectively reduced to 171 because of mergers, was sent questionnaires, of which 141 were completed and returned, giving a response rate of 82.5%.(ABSTRACT TRUNCATED AT 250 WORDS)

Outcome following epineurotomy in carpal tunnel syndrome: a prospective, randomized clinical trial.

To assess the efficacy of an adjunctive epineurotomy in carpal tunnel syndrome, 36 wrists in 33 patients were prospectively randomized into epineurotomy and non-epineurotomy treatment groups. The operating surgeons and evaluating therapist were double-blinded. Patients were evaluated preoperatively and at either 6 or 12 months postoperatively, with 15 patients examined at both postoperative time points. Evaluation consisted of five sensory and four motor tests: static and moving two-point discrimination, Semmes-Weinstein monofilament testing, vibratory (30 and 256 cps) sensibility, and dynamometer testing of grip strength and lateral, three-jaw, and tip pinch strengths. Sensory testing showed overall improvement within both groups postoperatively, but there was no difference between the two groups at either 6 or 12 months postoperatively. Motor testing revealed no improvement in the grip strength or lateral, three-jaw, or tip pinch of either group at 12 months when compared to preoperative levels. Twenty-four of 26 epineurotomy patients and all 10 control patients were satisfied with their clinical outcome 30 months after surgery. The addition of an adjunctive epineurotomy, although safe, offered no clinical benefit in the surgical treatment of carpal tunnel syndrome in this series.

Tips of the trade #34. Removal of broken rush pins.

Reported rates of nonunion with the nonoperative treatment of isolated humeral shaft fractures (nonpathologic bone) are low. Higher rates (13%) in open fractures are reported; open intramedullary nails may contribute to this nonunion rate. In this situation, when we identify a fractured pin, an anterolateral approach is used. The proximal pin is removed and the nonunion site is identified. The fibrous nonunion or pseudoarthrosis is excised and the distal pin fragment is identified in the intramedullary canal. A drill bit is used to remove the rod. Bone grafting is also generally utilized.

Injection injuries of the hand: Caveat doctor.

Airless gun injection injuries of the hand are a surgical emergency. The injection of paint or paint solvents are the most pernicious, whereas grease or diesel fuel injections have a better prognosis for the victim. Tissue necrosis and subsequent morbidity results from the diffusion of the noxious substance. Solvents and paint generate the most severe inflammatory response. Prompt major surgical treatment can minimize morbidity.

Rupture of the radial collateral ligament of the metacarpo-phalangeal joint of the index finger: a report of three cases.

We have diagnosed and treated three patients with complete rupture of the radial collateral ligament of the metacarpo-phalangeal joint of the index finger. Rupture of the radial collateral ligament of the metacarpo-phalangeal joint occurs most commonly in the little finger and has not previously been reported in the index finger. Operative treatment is recommended in all cases, due to the significant stresses placed on the radial side of the M.P. joint of the index finger.

Silicone synovitis following silicone implant arthroplasty.

Silicone synovitis is a late complication of silicone implant arthroplasty. The problem is usually heralded by pain and limitation of motion caused by synovitis and bone destruction. Once silicone synovitis develops, secondary procedures include removal of the implant, synovectomy, and reconstructive surgery individualized to the patient's pathology.

Silicone synovitis of the wrist.

Foreign body giant cell synovitis and focal bony destruction requiring secondary surgery developed in nine patients after carpal and radiocarpal arthroplasty with silicone rubber implants. Synovitis followed silicone rubber replacement of the lunate in four patients, the carpal scaphoid in two patients, and the trapezium in one patient, trapezial resurfacing hemiarthroplasty in one patient, and total wrist arthroplasty in one patient. All the removed implants were deformed. Some had changed in color from clear white at the time of insertion to yellow-white or deep yellow upon removal. Scanning electron microscopy of a silicone rubber implant of the lunate removed from one patient revealed extensive fibrillation in the capitate fossa. Light microscopy of the synovium revealed hyperplasia and hundreds of fragments of silicone particulate debris throughout the tissue adjacent to the implant. The silicone debris was surrounded by multinuclear foreign body giant cells in the eight patients from whom the synovium was studied. All patients required revision surgery. We believe that in the patients studied, synovitis represented a biologic reaction to the silicone fragments found scattered throughout the synovium for the following reasons: The synovitis found was not present before surgery (except in the patient with rheumatoid arthritis); the synovitis found was not associated with the condition for which replacement arthroplasty was performed (except in the patient with rheumatoid arthritis); synovitis subsided after implants were removed; and synovitis was noted histologically in areas of silicone debris and appeared directly related to silicone seeding. Fibrillation, fragmentation, and local seeding of silicone after carpal or radiocarpal arthroplasty appear related to gradual deformation of the implant, which was the result of repeated compressive loading and shearing. Clinically significant complications of rubber carpal or radiocarpal arthroplasty with silicone rubber implants may develop from silicone synovitis.

Conventional total hip arthroplasty for degenerative joint disease in patients between the ages of forty and sixty years.

We analyzed the records of 103 conventional hip arthroplasties in seventy-five active patients who were between the ages of forty and sixty years. After five to ten years of follow-up, an excellent or good clinical result was evident in 90 per cent. The radiographic appearance of the cement-bone interface of the acetabular component was stable in those hips, and no progressive acetabular radiolucency was found in 80 per cent of the hips. Of twenty hips with a complete acetabular radiolucency (Grade III or IV), only three had a secondary revision operation, two in conjunction with a fracture of the stem of the prosthesis and one for migration (Grade IV). Eight additional hips showed migration. Seventy per cent of the femoral components were well fixed, without radiographic evidence of loosening. A fracture of the femoral stem occurred in eight hips, all of which had a revision operation. One revision operation was done for loosening of the femoral stem. Seven femoral stems showed either shift or subsidence. An isolated radiolucency in the superolateral zone was present in four hips and an isolated lucency in other zones, measuring one millimeter or less, was present in ten hips. Thus, radiographic evidence of loosening, including the hips with a fractured stem, was present in 29.9 per cent. One additional revision, making ten in all, was done for symptomatic acetabular loosening. Based on this study, we concluded that conventional hip arthroplasty is a highly successful treatment in active patients between forty and sixty years old who have osteoarthritis of the hip.

Simultaneous fractures of both femoral necks: review of the literature and report of two cases.

Simultaneous fracture of both femoral necks is extremely rare. Delay in diagnosis may be avoided by noting the association of these fractures with two conditions: violent skeletal trauma and major motor seizures. Treatment of two patients is reported in addition to a review of seven cases previously reported. The author's experience indicates that accurate reduction and percutaneous Knowles pinning provide adequate fixation and permit early weight-bearing.

An antacid comparison trial.

A trial is described in which patients going into labour were randomly allocated to treatment with either Andursil or Magnesium Trisilicate Co. Following delivery of the baby the stomach is emptied and the volume and pH are measured. Table 5 summarizes the results of 1106 patients. Andursil was found to be more palatable by patients than was Magnesium Trisilicate Co, but the incidence of nausea and vomiting was similar in the two groups.

Subanaesthetic dosage of Althesin as a sedative for conservative dentistry. A controlled trial.

A randomized partial cross-over clinical trial of two intravenous techniques for outpatient conservative dentistry was performed in 61 patients. Subanaesthetic incremental doses of Althesin were used at 52 sessions and a single sedative dose of diazepam at 45 sessions. Each technique produced similar cardiovascular and respiratory changes. With Althesin, recovery after operation was more rapid and there was some evidence of a stronger anxiolytic effect and of less frequent and less severe thrombophlebitis. In contrast, Althesin was sometimes associated with jaw tremor or shivering and was less frequently mentioned by those patients who expressed a strong preference for one of the two techniques.

Bupivacaine carbonate and bupivacaine hydrochloride: a comparison of blood concentrations during epidural blockade for vaginal surgery.

Carbonated bupivacaine, plain bupivacaine hydrochloride, and bupivacaine hydrochloride with adrenaline were used to provide epidural analgesia for patients undergoing vaginal hysterectomy. Following injection to the blood concentrations of bupivacaine were measured at intervals over a period of 30 minutes. All three preparations produced satisfactory analgesia at a bupivacaine dose of 1.5 mg/kg body weight. The highest group mean blood concentrations were just outside the toxic dose range. Carbonated bupivacaine was absorbed most rapidly producing significantly higher blood concentrations up to 12 minutes after injection.