1.
Membr Cell Biol
; 14(5): 637-47, 2001 Jul.
Article
in English
| MEDLINE
| ID: mdl-11699867
ABSTRACT
Liposomes made from phosphatidylcholine (PC) or PC-fatty acid ester mixtures have been shown to induce an activation of the respiratory burst in human blood monocytes and alveolar macrophages (AM). Incorporation of 1,2-diacylglycerol or arachidonic acid into PC liposomes significantly enhanced the effect. In the case of AM, the effect of PC liposomes was similar to those of phorbol 12-myristate 13-acetate (PMA) and the ionophore A 23187, while in monocytes, PMA and A 23187 induced a stronger respiratory burst than PC liposomes. In the presence of PMA, higher liposomal concentrations were required to produce the maximum activation of the respiratory burst in both types of cells.
Subject(s)
Liposomes/pharmacology , Macrophage Activation/drug effects , Macrophages, Alveolar/drug effects , Monocytes/drug effects , Phospholipids/pharmacology , Respiratory Burst/drug effects , Arachidonic Acid/pharmacology , Calcimycin/pharmacology , Diglycerides/pharmacology , Fatty Acids/pharmacology , Humans , Ionophores/pharmacology , Macrophages, Alveolar/physiology , Monocytes/physiology , NADPH Oxidases/metabolism , Phosphatidylcholines/pharmacology , Tetradecanoylphorbol Acetate/pharmacology
2.
Biull Eksp Biol Med
; 126(7): 63-5, 1998 Jul.
Article
in Russian
| MEDLINE
| ID: mdl-9777200
Subject(s)
Lipids/pharmacology , Liposomes/pharmacology , Monocytes/drug effects , Respiratory Burst/drug effects , Diglycerides/pharmacology , Esters , Fatty Acids/pharmacology , Gangliosides/pharmacology , Humans , In Vitro Techniques , Lipids/chemistry , Liposomes/chemistry , Monocytes/metabolism , Phosphatidylcholines/pharmacology
3.
Biull Eksp Biol Med
; 124(11): 520-3, 1997 Nov.
Article
in Russian
| MEDLINE
| ID: mdl-9471245