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Middle East J Anaesthesiol ; 18(5): 947-54, 2006 Jun.
Article in English | MEDLINE | ID: mdl-17094534

ABSTRACT

In this prospective case-series study, a balanced anesthetic scheme of sevoflurane in nitrous oxide supplemented with remifentanil and sustained neuromuscular block was applied in nine patients scheduled for laparoscopic adrenalectomy for pheochromocytoma. Laparoscopic adrenalectomy to treat pheochromocytoma results in marked catecholamine release during pneumoperitoneum and tumor manipulation. Remifentanil infusion was adjusted to maintain systolic arterial pressure between 120-170 mmHg. Increased infusion rate of remifentanil was used (up to 3 microg/kg/min) to prevent and treat marked hemodynamic changes from catecholamine release during tumor manipulation. Hpotension after tumor removal was treated with additional colloids fluids and decreasing the remifentanil infusion rate by 25-50%.


Subject(s)
Adrenal Gland Neoplasms/surgery , Adrenalectomy/methods , Blood Pressure/drug effects , Heart Rate/drug effects , Laparoscopy/methods , Pheochromocytoma/surgery , Piperidines/therapeutic use , Adrenalectomy/adverse effects , Adult , Anesthetics, Inhalation/administration & dosage , Anesthetics, Intravenous/adverse effects , Anesthetics, Intravenous/therapeutic use , Catecholamines/metabolism , Dose-Response Relationship, Drug , Female , Humans , Hypotension/prevention & control , Laparoscopy/adverse effects , Male , Methyl Ethers/administration & dosage , Middle Aged , Neuromuscular Blockade/methods , Nitrous Oxide/administration & dosage , Piperidines/adverse effects , Postoperative Nausea and Vomiting , Prospective Studies , Remifentanil , Sevoflurane , Treatment Outcome
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