Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters









Database
Language
Publication year range
1.
Deregulated expression of fat and muscle genes in B-cell chronic lymphocytic leukemia with high lipoprotein lipase expression.
Bilban, M; Heintel, D; Scharl, T; Woelfel, T; Auer, M M; Porpaczy, E; Kainz, B; Kröber, A; Carey, V J; Shehata, M; Zielinski, C; Pickl, W; Stilgenbauer, S; Gaiger, A; Wagner, O; Jäger, U.
Leukemia ; 20(6): 1080-8, 2006 Jun.
Article in English | MEDLINE | ID: mdl-16617321

ABSTRACT

Lipoprotein lipase (LPL) is a prognostic marker in B-cell chronic lymphocytic leukemia (B-CLL) related to immunoglobulin V(H) gene (IgV(H))mutational status. We determined gene expression profiles using Affymetrix U133A GeneChips in two groups of B-CLLs selected for either high ('LPL+', n=10) or low ('LPL-', n=10) LPL mRNA expression. Selected genes were verified by real-time PCR in an extended patient cohort (n=42). A total of 111 genes discriminated LPL+ from LPL- B-CLLs. Of these, the top three genes associated with time to first treatment were Septin10, DMD and Gravin (P

Subject(s)
Gene Expression Regulation, Enzymologic , Gene Expression Regulation, Leukemic , Immunoglobulin Heavy Chains/genetics , Immunoglobulin Variable Region/genetics , Leukemia, Lymphocytic, Chronic, B-Cell/enzymology , Leukemia, Lymphocytic, Chronic, B-Cell/genetics , Lipoprotein Lipase/genetics , Cohort Studies , Cytoskeletal Proteins/genetics , Dystrophin/genetics , Fatty Acids/genetics , Fatty Acids/metabolism , GTP Phosphohydrolases/genetics , Gene Expression Profiling , Humans , Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis , Lipoprotein Lipase/biosynthesis , Mutation , RNA, Messenger/genetics , Reverse Transcriptase Polymerase Chain Reaction , Septins
SEND TO:
Email
Export
Print
RSS
XML
SELECTION OF CITATIONS
SEARCH DETAIL