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1.
Int Marit Health ; 73(3): 119-124, 2022.
Article in English | MEDLINE | ID: mdl-36217973

ABSTRACT

BACKGROUND: The waters surrounding the French Southern Lands are a fishing zone, accessible only by sailing for several days in a region where weather conditions are often difficult. The scientific bases of the region have medical staff whose services can be called upon if seafarers require assessment and rapid medical treatment. We conducted an epidemiological study of the maritime teleconsultations carried out by the French Telemedical Maritime Assistance Service (TMAS), where patients navigating in the Southern Indian Ocean zone were advised to disembark on the medical bases in the French Southern Lands, between 2015 and 2020, to receive medical treatment. MATERIALS AND METHODS: We extracted data from all of the maritime records from 1 January 2015 to 31 December 2020 relating to patients who attended a maritime teleconsultation with a French TMAS doctor in the Southern Indian Ocean zone and who had been redirected to the medical bases in the French Southern Lands. Data were collected on the patients' age, gender, nationality, rank, type of vessel, teleconsultation diagnosis, patient management on board and in the French Southern Lands medical bases, as well as the medical outcome. We carried out a descriptive data analysis. RESULTS: French TMAS doctors managed 11,908 cases including 76 in the Southern Indian Ocean zone (0.6%). Nineteen (25%) patients were redirected to the French Southern Lands over the study period. Eighteen patients were men with an average age of 45 ± 10 years. Eighteen patients were on board a trawler and 11 of them were sailors. Nine patients were treated for a trauma-related condition, 8 for a medical condition and 2 for a surgical disease. Eleven (58%) patients were evacuated to Reunion Island and 8 (42%) patients received medical treatment and were able to re-embark aboard their vessel. CONCLUSIONS: Relatively few patients are redirected to the French Southern Lands for medical assistance, but referrals occur on a regular basis. The presence of these medical bases is unusual in a maritime setting, but they can be a valuable asset when maritime medical assistance is required in this region. The type of condition encountered, and the patient profile, were typical of the fishing community. The presence of these bases and communication between the various stakeholders delivering maritime medical assistance provided these patients with optimal care despite their isolated location.


Subject(s)
Naval Medicine , Telemedicine , Adult , Antarctic Regions , Female , Humans , Indian Ocean , Male , Middle Aged , Ships
2.
Int Marit Health ; 70(4): 220-225, 2019.
Article in English | MEDLINE | ID: mdl-31891175

ABSTRACT

BACKGROUND: The medical kit is the basis of medical support in maritime environment; it is defined by international or national regulations and guidelines. For offshore races, rules and recommendations are proposed by national or international sailing federations. Sailing and racing offshore alone presents specificities that sometimes make it difficult to apply the usual recommendations. The epidemiology of single-handed offshore race is dominated by traumatic risks. Medical events are relatively rare because competitors are high-level athletes, generally young and subject to complete medical assessments. The scarcity of available scientific data makes it necessary to choose appropriate methods for developing recommendations. The purpose of this work is to propose a medical kit adapted and applicable to these situations. MATERIALS AND METHODS: The method used was that of "Professional recommendations by formal consensus of experts" derived from the Rand/UCLA method. After a critical analysis of the literature, a panel of 19 experts having expertise in medicine in maritime environment was gathered from various medical specialties (cardiologist, internist, intensivist and emergency physician, ear-nose-throat physician and general practitioner) and from varied medical activities. They had not declared any direct conflict of interest. RESULTS: A medical kit proposal has been developed. The choice of drugs was based on the analysis of the epidemiology of medical events observed during the last offshore races. The experts' choice was to reduce the quantity of medication and medical devices in order to limit the risk of confusion of medicines and dosages. Drugs with significant side effects or requiring third party monitoring have been removed. Medical devices designed to do an intervention impossible to perform on oneself have also been eliminated. CONCLUSIONS: Solo sailing remains a marginal maritime activity with specific risks. The development of single-handed races requires an adaptation of medical support through the development of a specific medical kit and adapted training. The formalised consensus of experts seems to be an appropriate method for developing recommendations in the field of maritime medicine.


Subject(s)
First Aid/instrumentation , Naval Medicine/standards , Ships , Water Sports , First Aid/standards , Humans
4.
Int Marit Health ; 68(1): 7-11, 2017.
Article in English | MEDLINE | ID: mdl-28357830

ABSTRACT

BACKGROUND: A single-handed transatlantic rowing race was organised between Senegal and French Guyana (2600 nautical miles). During the race, rowers adjust their lifestyle to maintain an optimal level of performance. Nutrition, circadian rhythm disturbance, psychological state, pain and other medical problems impact on physical abilities and increase the occurrence of accidents. We surveyed the prevalence of medical complications during this race and the preparation that we could suggest for this kind of activity. MATERIALS AND METHODS: This is a descriptive, retrospective case series study. Follow-up consisted of sending out a questionnaire and performing individual interviews. RESULTS: A total of 23 participants including 1 woman and 22 men; mean age of 46.5 years (range: 35-59) entered the race. The race lasted for 39 to 52 days with participants rowing between 10 and 12 h/day. Nine participants dropped out. Energy intake was 4500 to 6000 kcal/day and fluid intake was 4 to 5.5 L/day. Mean weight loss was 13.3 kg. The resting period was 6 ± 1 h/24 h divided into 1.5 to 2 h periods essentially during darkness. A total of 92% of the racers required medical care for dermatological problems; other conditions requiring medical care were: tendinitis in 10 cases, diarrhoea in 4, moderate to severe seasickness in 4, hallucinations in 3, panic attacks in 2, burns in 2, and disembarkation syndrome ("land sickness") lasting from 45 min to 6 h in 13. CONCLUSIONS: Physiological and psychological impact of this type of event is still unclear. The most common medical problems are dermatological, rheumatological complications and minor trauma. Medical and psychological preparation should be offered to candidates for these competitions.


Subject(s)
Skin Diseases/epidemiology , Sports Medicine/methods , Adult , Atlantic Ocean , Female , Follow-Up Studies , Humans , Male , Middle Aged , Motion Sickness/epidemiology , Naval Medicine , Nutritional Status , Retrospective Studies , Sleep , Sports Medicine/statistics & numerical data , Wounds and Injuries/epidemiology
5.
Int J Inj Contr Saf Promot ; 23(3): 317-22, 2016 Sep.
Article in English | MEDLINE | ID: mdl-26082429

ABSTRACT

Drowning affects more than 500,000 people worldwide and is responsible for at least 350,000 deaths each year. In France, 1235 drowning resulting in 496 deaths were recorded in the summer 2012. This retrospective study has investigated the epidemiology of drowning in the city of Marseille (South of France) between 2000 and 2011. We identified 449 cases of unintentional drowning. The highest incidence was found among males with a median age of 36 years. The incidence was 5.3 victims per 10,000 inhabitants with a mortality rate of 1.2 per 10,000. These accidents occurred mainly at sea (89%) and during the summer season. A majority of drowning victims (69%) were admitted in a hospital. This is the only study in France to analyse data on drowning throughout the year and over a long period. Drowning is a serious condition burdened by 22% of victims who die.


Subject(s)
Drowning/epidemiology , Adolescent , Adult , Age Factors , Aged , Child , Child, Preschool , Drowning/mortality , Female , France/epidemiology , Hospitalization/statistics & numerical data , Humans , Incidence , Infant , Male , Mediterranean Sea/epidemiology , Middle Aged , Retrospective Studies , Risk Factors , Sex Factors , Young Adult
8.
Prehosp Disaster Med ; 28(4): 370-5, 2013 Aug.
Article in English | MEDLINE | ID: mdl-23651794

ABSTRACT

INTRODUCTION: Ambulance drivers often travel under stressful conditions at high speed while using vehicles with poor high-speed maneuverability. The occupant safety of ambulance vehicles has not yet been addressed by the automotive safety paradigm; particularly for the rear patient compartment. This study had two objectives: (1) to assess by survey the French Emergency Medical Services (EMS) to determine the layout of the vehicle most often used and the EMS personnel's behavior during transport; and (2) to conduct a crash test to analyze the injuries which may affect EMS personnel and patients in the rear patient compartment. METHOD: Firstly, a survey was distributed to the 50 largest metropolitan French EMS programs. Secondly, a crash test was performed with a Mobile Intensive Care Unit (MICU) in conditions closest to reality. RESULTS: Forty-nine of the 50 biggest metropolitan French EMS programs responded to the survey. This represents 108 French MICUs. During the last three years, 12 of 49 EMS programs (24%) identified at least one accident with an MICU, and six of these 12 (50%) suffered at least one death in those accidents. A crash test using a typical French EMS MICU showed that after impact of a collision, the ambulance was moved more than five meters with major consequences for all passengers. A study-approved human cadaver placed in the position of a potential patient was partially thrown from the stretcher with a head impact. The accelerometric reaction of the anthropomorphic manikin head was measured at 48G. CONCLUSION: The crash test demonstrated a lack of safety for EMS personnel and patients in the rear compartment. It would be preferable if each piece of medical equipment were provided with a quick release system resistant to three-dimensional 10G forces. The kinetic changes undergone by the "patient" substitute on the stretcher would probably have an effect of causing injury pathology. This study highlights the need for more research and development in this area.


Subject(s)
Accidents, Traffic/prevention & control , Ambulances/standards , Equipment Safety/methods , Occupational Health , Patient Safety , Emergency Medical Services/standards , Equipment Design , France , Health Care Surveys , Humans , Intensive Care Units/standards , Mobile Health Units/standards , Workforce
9.
PLoS One ; 8(3): e58111, 2013.
Article in English | MEDLINE | ID: mdl-23469263

ABSTRACT

BACKGROUND: Patients admitted to intensive care units are frequently exposed to pathogenic microorganisms present in their environment. Exposure to these microbes may lead to the development of hospital-acquired infections that complicate the illness and may be fatal. Amoeba-associated microorganisms (AAMs) are frequently isolated from hospital water networks and are reported to be associated to cases of community and hospital-acquired pneumonia. METHODOLOGY/PRINCIPAL FINDINGS: We used a multiplexed immunofluorescence assay to test for the presence of antibodies against AAMs in sera of intensive care unit (ICU) pneumonia patients and compared to patients at the admission to the ICU (controls). Our results show that some AAMs may be more frequently detected in patients who had hospital-acquired pneumonia than in controls, whereas other AAMs are ubiquitously detected. However, ICU patients seem to exhibit increasing immune response to AAMs when the ICU stay is prolonged. Moreover, concomitant antibodies responses against seven different microorganisms (5 Rhizobiales, Balneatrix alpica, and Mimivirus) were observed in the serum of patients that had a prolonged ICU stay. CONCLUSIONS/SIGNIFICANCE: Our work partially confirms the results of previous studies, which show that ICU patients would be exposed to water amoeba-associated microorganisms, and provides information about the magnitude of AAM infection in ICU patients, especially patients that have a prolonged ICU stay. However, the incidence of this exposure on the development of pneumonia remains to assess.


Subject(s)
Antibodies, Bacterial/blood , Cross Infection/diagnosis , Gram-Negative Bacteria/isolation & purification , Gram-Negative Bacterial Infections/diagnosis , Gram-Positive Bacteria/isolation & purification , Gram-Positive Bacterial Infections/diagnosis , Mimiviridae/isolation & purification , Pneumonia/diagnosis , Adult , Cross Infection/blood , Cross Infection/microbiology , Gram-Negative Bacterial Infections/blood , Gram-Negative Bacterial Infections/microbiology , Gram-Positive Bacterial Infections/blood , Gram-Positive Bacterial Infections/microbiology , Humans , Intensive Care Units , Length of Stay , Pneumonia/blood , Pneumonia/microbiology , Seroepidemiologic Studies
10.
Eur J Emerg Med ; 20(1): 39-44, 2013 Feb.
Article in English | MEDLINE | ID: mdl-22343694

ABSTRACT

BACKGROUND: The Emergency Medical Services (EMS) play a primordial role in the early management of adults with acute ischaemic stroke (AIS). The aim of this study was to evaluate the role and effectiveness of the EMS in the stroke chain of survival in Marseille. METHODS: A retrospective observational study was conducted in patients treated for AIS or transient ischaemic attack in three emergency departments and at the Marseille stroke centre over a period of 12 months. RESULTS: In 2009, of 1034 patients ultimately presenting a diagnosis of AIS or transient ischaemic attack, 74% benefited from EMS activation. Dispatchers correctly diagnosed 57% of stroke patients. The symptoms most frequently reported included limb weakness, speech problems and facial paresis. Elements resulting in misdiagnosis by dispatchers were general discomfort, chest pain, dyspnoea, fall or vertigo. Stroke patients not diagnosed by emergency medical dispatchers but calling within 3 h of symptom onset accounted for 20% of cases. CONCLUSION: Our study demonstrates that public intervention programmes must stress the urgency of recognizing stroke symptoms and the importance of calling EMS through free telephone numbers. Further efforts are necessary to disseminate guidelines for healthcare providers concerning stroke recognition and the new therapeutic possibilities in order to increase the likelihood of acute stroke patients presenting to a stroke team early enough to be eligible for acute treatment. In addition, EMS dispatchers should receive further training about atypical stroke symptoms, and 'Face Arm Speech Test' tests must be included in the routine questionnaires used in emergency medical calls concerning elderly persons.


Subject(s)
Brain Ischemia/diagnosis , Emergency Medical Services , Stroke/diagnosis , Aged , Aged, 80 and over , Brain Ischemia/mortality , Female , France , Humans , Ischemic Attack, Transient/diagnosis , Male , Middle Aged , Stroke/mortality
12.
PLoS One ; 7(2): e32486, 2012.
Article in English | MEDLINE | ID: mdl-22389704

ABSTRACT

Despite the considerable number of studies reported to date, the causative agents of pneumonia are not completely identified. We comprehensively applied modern and traditional laboratory diagnostic techniques to identify microbiota in patients who were admitted to or developed pneumonia in intensive care units (ICUs). During a three-year period, we tested the bronchoalveolar lavage (BAL) of patients with ventilator-associated pneumonia, community-acquired pneumonia, non-ventilator ICU pneumonia and aspiration pneumonia, and compared the results with those from patients without pneumonia (controls). Samples were tested by amplification of 16S rDNA, 18S rDNA genes followed by cloning and sequencing and by PCR to target specific pathogens. We also included culture, amoeba co-culture, detection of antibodies to selected agents and urinary antigen tests. Based on molecular testing, we identified a wide repertoire of 160 bacterial species of which 73 have not been previously reported in pneumonia. Moreover, we found 37 putative new bacterial phylotypes with a 16S rDNA gene divergence ≥ 98% from known phylotypes. We also identified 24 fungal species of which 6 have not been previously reported in pneumonia and 7 viruses. Patients can present up to 16 different microorganisms in a single BAL (mean ± SD; 3.77 ± 2.93). Some pathogens considered to be typical for ICU pneumonia such as Pseudomonas aeruginosa and Streptococcus species can be detected as commonly in controls as in pneumonia patients which strikingly highlights the existence of a core pulmonary microbiota. Differences in the microbiota of different forms of pneumonia were documented.


Subject(s)
Intensive Care Units , Pneumonia/microbiology , Bacteria/classification , Bacteria/genetics , Bacteria/isolation & purification , Bronchoalveolar Lavage Fluid/microbiology , DNA, Ribosomal/genetics , Humans , Molecular Sequence Data , Phylogeny
13.
Am J Emerg Med ; 30(6): 1015.e1-2, 2012 Jul.
Article in English | MEDLINE | ID: mdl-21703802

ABSTRACT

Pulmonary embolism (PE) is a common cause of sudden death; the use of prehospital thrombolysis is currently a last-resort option and requires a prolonged cardiopulmonary resuscitation (CPR). Novel mechanical devices have recently been introduced that provides automatic mechanical chest compression (AMCC) according to the guidelines and continually without decrease efficiency throughout prolonged resuscitation. A 54 year-old woman with a history of breast cancer experienced sudden chest pain and severe dyspnea. A mobile intensive care unit was dispatched to her home. During physical examination, she suddenly collapsed with pulseless electrical activity as the initial rhythm. Prehospital thrombolysis during CPR combined with use of AMCC was performed based on a strongly suspected diagnosis of massive PE. After 75 minutes of effective CPR, return of spontaneous circulation was attained. After admission to an intensive care unit, computed tomographic scan confirmed bilateral PE. The patient was discharged 3 weeks after CPR in good neurologic condition. To our knowledge, this is the first case describing combined use of thrombolysis and AMCC in out-ofhospital cardiac arrest. However, for the time being, prehospital thrombolysis in CPR continues to be a measure that should only be performed on a case-by-case basis based on informed decision. Further studies are needed to evaluate the efficacy and safety of AMCC with thrombolysis and thus prolonged CPR.


Subject(s)
Cardiopulmonary Resuscitation , Emergency Medical Services , Out-of-Hospital Cardiac Arrest/therapy , Pulmonary Embolism/therapy , Thrombolytic Therapy , Cardiopulmonary Resuscitation/methods , Emergency Medical Services/methods , Female , Humans , Middle Aged , Out-of-Hospital Cardiac Arrest/etiology , Pulmonary Embolism/complications , Thrombolytic Therapy/methods
14.
Am J Ind Med ; 54(11): 819-25, 2011 Nov.
Article in English | MEDLINE | ID: mdl-22006591

ABSTRACT

BACKGROUND: The short-term effects of smoke inhalation have been little studied in European wildland firefighters, especially in an intra-individual design. Our purpose is to study the spirometric changes from the early stage during a wildland fire season and to compare smokers and non-smokers. METHODS: A population of 108 firefighters from a Civil Security Unit, based in Corsica, was tested immediately after having been exposed to the smoke of coniferous trees. RESULTS: Out of 108 people, 59 were smokers and 49 were non-smokers without any acute or chronic pulmonary disease. Compared to baseline values, a decrease of spirometric parameters was observed immediately after the end of exposure and an even greater decrease was seen after 24 hr (FEV1 -0.53 L; FVC -0.59 L; PEF -53 L min(-1), P < 0.05 for each). None of the participants complained of respiratory symptoms. Three months after the end of the season, a final test was given which revealed a persistent decrease in spirometric parameters in comparison with baseline values (FEV1 -0.28 L; FVC -0.34 L; PEF -45 L min(-1), P < 0.05 for each). Comparison of smoking and non-smoking groups did not show any noteworthy difference for each parameter or the importance of their decline. CONCLUSIONS: The findings show that firefighters are likely to develop respiratory impairments after wood smoke exposure. We did not observe any statistical differences between smokers and non-smokers.


Subject(s)
Firefighters , Fires/statistics & numerical data , Occupational Exposure/adverse effects , Smoke Inhalation Injury/complications , Spirometry , Female , France/epidemiology , Humans , Lung Diseases/epidemiology , Lung Diseases/etiology , Male , Occupational Medicine , Predictive Value of Tests , Prospective Studies , Smoke Inhalation Injury/diagnosis , Statistics, Nonparametric , Time Factors , Young Adult
15.
Presse Med ; 40(3): e145-51, 2011 Mar.
Article in French | MEDLINE | ID: mdl-21251791

ABSTRACT

OBJECTIVE: The aim of this study is to report the observation of the pandemic of influenza A (H1N1 virus) from August to September 2009 on the island of Futuna, in a context of isolated island that may mimic an environment closed. METHOD: We conducted a prospective observational study of influenza-like illness, from the first confirmed case of influenza A on the island until the end of the epidemic wave. RESULTS: From August 15 to September 20, 2009, 1536 cases of influenza syndrome were identified. The estimate of the overall clinical attack rate was 36 %. The evolution of the epidemic shows an explosion of new cases of influenza A and subsequently a rapid decline of the epidemic. The spread of the infection was made by contiguity, jumping from one city to another. The cumulative number of cases by age group shows that the majority of cases were children and young adults under the age of 20 years. The most frequent symptoms were cough, rhinorrhea, headache, myalgia or asthenia, and fever. CONCLUSION: This study, despite these limitations, shows an explosive epidemic of influenza A, which can be explained by the circulation of virus that has been fostered by gatherings of public and closed environment. Age group classification shows that majority of cases were young, in contrast to seasonal influenza, but the symptoms were alike. This study highlights the difficulties to manage an epidemic surveillance system at high level and given the quick spread of the disease.


Subject(s)
Influenza A Virus, H1N1 Subtype , Influenza, Human/epidemiology , Pandemics/statistics & numerical data , Adolescent , Adult , Aged , Aged, 80 and over , Child , Child, Preschool , Cross-Sectional Studies , Female , Humans , Infant , Influenza, Human/diagnosis , Influenza, Human/transmission , Male , Middle Aged , Polynesia , Population Surveillance , Social Isolation , Young Adult
16.
Eur J Emerg Med ; 18(2): 99-101, 2011 Apr.
Article in English | MEDLINE | ID: mdl-20881842

ABSTRACT

INTRODUCTION: Serious pulmonary and cardiac failure may be treated with extracorporeal membrane oxygenation (ECMO) when the conventional treatment fails. Improvements in extracorporeal circulation devices have allowed us to set up two specialized mobile units: a mobile cardiac assistance unit (MCAU) and a mobile respiratory assistance unit (MRAU). Their role is to provide ECMO at patient's bedside, and then to ensure inter-hospital transport (IHT). The aim of this study was to evaluate our experiences with the transportation of patients on ECMO. METHODS: We performed two prospective observational studies, the first on IHT requiring MCAU during 3 years and the second on IHT requiring MRAU during 6 months. RESULTS: Thirty-two patients needed MCAU. The median age is 40 years. The median distance travelled is 45 km. The median time of arrival at patient bedside is 49 min. Causes of cardiac shock were: myocarditis (28.1%), acute heart failure of unknown aetiology (21.9%), drug-induced cardiovascular failure (18.8%), post-infarction cardiac failure (12.5%), post-cardiac surgery (12.5%) and refractory cardiac arrest (6.2%). Thirty days mortality was 40%. Eleven patients needed MRAU. The median age was 33 years. The median distance travelled is 40 km; the median time of arrival at patient bedside is 47 min. All patients had severe acute respiratory distress syndrome complicating severe H1N1 virus infection. Thirty days mortality was 65%. In both the cases, all transportations were uneventful. CONCLUSION: This study shows that mobile ECMO system can be successfully and quickly established at patient's bedside, and that transportation of patients on ECMO can be performed safely and without technical difficulties.


Subject(s)
Ambulances , Emergency Medical Services/methods , Emergency Medicine/instrumentation , Extracorporeal Membrane Oxygenation/instrumentation , Heart Failure/therapy , Respiratory Insufficiency/therapy , Adult , Cohort Studies , Emergencies , Emergency Medicine/methods , Extracorporeal Membrane Oxygenation/methods , Female , France , Heart Failure/diagnosis , Heart Failure/mortality , Humans , Male , Middle Aged , Prospective Studies , Respiratory Insufficiency/diagnosis , Respiratory Insufficiency/mortality , Risk Assessment , Survival Analysis , Transportation of Patients , Treatment Outcome
17.
Resuscitation ; 81(11): 1516-20, 2010 Nov.
Article in English | MEDLINE | ID: mdl-20621409

ABSTRACT

BACKGROUND: Securing the airway in emergency is among the key requirements of appropriate prehospital therapy. The Easytube (Ezt) is a relatively new device, which combines the advantages of both an infraglottic and supraglottic airway. AIMS: Our goal was to evaluate the effectiveness and the safety of use of Ezt by emergency physicians in case of difficult airway management in a prehospital setting with minimal training. METHODS: We performed a prospective multi-centre observational study of patients requiring airway management conducted in prehospital emergency medicine in France by 3 French mobile intensive care units from October 2007 to October 2008. RESULTS: Data were available for 239 patients who needed airway management. Two groups were individualized: the "easy airway management" group (225 patients; 94%) and the "difficult airway management" group (14 patients; 6%). All patients had a successful airway management. The Ezt was used in eight men and six women; mean age was 64 years. It was used for ventilation for a maximum of 150 min and the mean time was 65 min. It was positioned successfully at first attempt, except for two patients, one needed an adjustment because of an air leak, and in the other patient the Ezt was replaced due to complete obstruction of the Ezt during bronchial suction. CONCLUSION: The present study shows that emergency physicians in cases of difficult airway management can use the EzT safely and effectively with minimal training. Because of its very high success rate in ventilation, the possibility of blind intubation, the low failure rate after a short training period. It could be introduced in new guidelines to manage difficult airway in prehospital emergency.


Subject(s)
Emergency Medical Services/methods , Intubation, Intratracheal/instrumentation , Respiration, Artificial/instrumentation , Adolescent , Adult , Aged , Aged, 80 and over , Child , Child, Preschool , Female , France , Humans , Infant , Infant, Newborn , Male , Middle Aged , Prospective Studies , Treatment Outcome
18.
Emerg Infect Dis ; 16(2): 258-63, 2010 Feb.
Article in English | MEDLINE | ID: mdl-20113556

ABSTRACT

Tropheryma whipplei is the etiologic pathogenic agent of Whipple disease (WD), characterized by various clinical signs, such as diarrhea, weight loss, lymphadenopathy, and polyarthritis. PCR-based methods for diagnosis of WD have been developed. T. whipplei has been identified in saliva and stool samples from patients with WD and from healthy persons. T. whipplei DNA has also been found in bronchoalveolar lavage (BAL) samples of a child with pneumonia. We detected DNA of T. whipplei in 6 (3%) of 210 BAL samples collected in intensive care units by using 16S rDNA and specific quantitative PCR. We identified 4 novel genotypes of T. whipplei. In 1 case, T. whipplei was the only bacterium; in 4 others, it was associated with buccal flora. We suggest that T. whipplei should be investigated as an etiologic agent of pneumonia.


Subject(s)
Actinomycetales Infections/microbiology , Bronchoalveolar Lavage Fluid/microbiology , Pneumonia, Bacterial/microbiology , Tropheryma/isolation & purification , Adolescent , Adult , Aged , Aged, 80 and over , Community-Acquired Infections/microbiology , Humans , Intensive Care Units , Male , Middle Aged , Polymerase Chain Reaction , Population Surveillance , Saliva/microbiology , Young Adult
19.
J Trauma ; 68(2): 395-400, 2010 Feb.
Article in English | MEDLINE | ID: mdl-20154552

ABSTRACT

BACKGROUND: The development of an early-onset pneumonia (EOP), occurring within the first 72 hours after admission, represents a critical event in severe thoracic trauma population. The aim of this study was to determine risk factors associated with the occurrence of this complication in this specific population. METHODS: A retrospective review of a prospective implemented trauma registry was conducted during a 4-year period in a Level I trauma center. Over the study period, 223 severely injured patients were admitted with severe thoracic trauma (Injury Severity Score >16 and Thorax Abbreviated Injury Score >2). Multiple logistic regression analysis was used to determine the independent predictors of EOP based on the clinical characteristics and the initial management both in the field and after admission in the trauma center. RESULTS: Independent predictors of EOP were the necessity of intubation and mechanical ventilation in the field (adjusted odds ratio [OR]: 11.8; 95% confidence interval [CI]: 4.3-32.7), a history of aspiration (OR: 28.6; 95% CI: 4.0-203.5), the presence of pulmonary contusion (OR: 7.0; 95% CI: 2.0-23.9), and the occurrence of a hemothorax (OR: 3.2; 95% CI: 1.4-7.6). CONCLUSION: These results emphasize the influence of prehospital and early factors in the further occurrence of EOP, which allows the development of early and specific clinical management to prevent it.


Subject(s)
Pneumonia/etiology , Thoracic Injuries/complications , Adult , Drainage , Female , Humans , Injury Severity Score , Logistic Models , Male , Middle Aged , Pneumonia/prevention & control , Respiration, Artificial , Retrospective Studies , Risk Factors , Time Factors , Young Adult
20.
Therapie ; 63(6): 419-23, 2008.
Article in French | MEDLINE | ID: mdl-19236833

ABSTRACT

OBJECTIVE: We have performed a survey on the use of aspirin in decompression sickness (DCS) treatment in French hyperbaric centers'. We also conducted a review of literature to determine if aspirin was beneficial to treat human victims of DCS. METHODS: Prospective observational study investigating French hyperbaric centers' prescription of aspirin to DCS' divers victims. The question we asked by mail or phone to French hyperbaric centers was: Do you give some aspirin to a diver with DCS if this treatment has not been given yet (on the site of accident). RESULTS: A large majority of French hyperbaric centers (77.5%) consider aspirin in DCS treatment. However this practice is not consensual. There is no evidence from the literature to support the efficiency of aspirin in DCS. CONCLUSIONS: Although aspirin is widely used for DCS treatment in France, more research is needed to determine if aspirin is useful.


Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Aspirin/therapeutic use , Decompression Sickness/drug therapy , Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Aspirin/adverse effects , Data Collection , Drug Utilization , France , Humans , Prospective Studies
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