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1.
Ann Surg Oncol ; 31(5): 3325-3338, 2024 May.
Article in English | MEDLINE | ID: mdl-38341381

ABSTRACT

BACKGROUND: Ovarian pseudomyxoma peritonei (OPMP) are rare, without well-defined therapeutic guidelines. We aimed to evaluate cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) to treat OPMP. METHODS: Patients from the French National Network for Rare Peritoneal Tumors (RENAPE) database with proven OPMP treated by CRS/HIPEC and with histologically normal appendix and digestive endoscopy were retrospectively included. Clinical and follow-up data were collected. Histopathological and immunohistochemical features were reviewed. RESULTS: Fifteen patients with a median age of 56 years were included. The median Peritoneal Cancer Index was 16. Following CRS, the completeness of cytoreduction (CC) score was CC-0 for 9/15 (60%) patients, CC-1 for 5/15 (33.3%) patients, and CC-2 for 1/15 (6.7%) patients. The median tumor size was 22.5 cm. After pathological review and immunohistochemical studies, tumors were classified as Group 1 (mucinous ovarian epithelial neoplasms) in 3/15 (20%) patients; Group 2 (mucinous neoplasm in ovarian teratoma) in 4/15 (26.7%) patients; Group 3 (mucinous neoplasm probably arising in ovarian teratoma) in 5/15 (33.3%) patients; and Group 4 (non-specific group) in 3/15 (20%) patients. Peritoneal lesions were OPMP pM1a/acellular, pM1b/grade 1 (hypocellular) and pM1b/grade 3 (signet-ring cells) in 13/15 (86.7%), 1/15 (6.7%) and 1/15 (6.7%) patients, respectively. Disease-free survival analysis showed a difference (p = 0.0463) between OPMP with teratoma/likely-teratoma origin (groups 2 and 3; 100% at 1, 5, and 10 years), and other groups (groups 1 and 4; 100%, 66.6%, and 50% at 1, 5, and 10 years, respectively). CONCLUSION: These results suggested that a primary therapeutic strategy using complete CRS/HIPEC for patients with OPMP led to favorable long-term outcomes.


Subject(s)
Appendiceal Neoplasms , Hyperthermia, Induced , Neoplasms, Cystic, Mucinous, and Serous , Pseudomyxoma Peritonei , Teratoma , Female , Humans , Middle Aged , Pseudomyxoma Peritonei/pathology , Hyperthermic Intraperitoneal Chemotherapy , Cytoreduction Surgical Procedures/methods , Retrospective Studies , Hyperthermia, Induced/methods , Appendiceal Neoplasms/therapy , Appendiceal Neoplasms/pathology , Combined Modality Therapy , Survival Rate
2.
Ann Pathol ; 24(3): 259-63; quiz 227, 2004 Jun.
Article in French | MEDLINE | ID: mdl-15480261

ABSTRACT

Histiocytoid carcinoma of the breast, a cellular variant of invasive breast cancer, is mainly found among infiltrating lobular carcinomas (ILC). It can be easily confused with benign conditions or other mammary tumors also composed of cells with a pink granular to foamy cytoplasm and an eccentric nucleus. We report 3 cases of histiocytoid ILC. Our aim is to discuss recent immunocytochemical data that could suggest a special type of apocrine differentiation of tumor cells, including a diffuse immunoreactivity for GCDFP-15 (Gross Cystic Disease Fluid Protein 15) and a predominant expression of androgen receptor, and to describe the features useful for the differential diagnosis.


Subject(s)
Apolipoproteins , Breast Neoplasms/pathology , Carcinoma, Lobular/pathology , Membrane Transport Proteins , Aged , Apolipoproteins D , Breast Neoplasms/chemistry , Breast Neoplasms/diagnosis , Carcinoma, Lobular/chemistry , Carcinoma, Lobular/diagnosis , Carrier Proteins/analysis , Cell Differentiation , Cell Nucleus/ultrastructure , Cytoplasm/ultrastructure , Diagnosis, Differential , Female , Glycoproteins/analysis , Histiocytes/chemistry , Histiocytes/ultrastructure , Humans , Lymphatic Metastasis , Middle Aged , Neoplasm Proteins/analysis , Postmenopause , Receptors, Androgen/analysis
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