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1.
Neurology ; 74(5): 392-8, 2010 Feb 02.
Article in English | MEDLINE | ID: mdl-20124204

ABSTRACT

BACKGROUND: The unambiguous identification of the epileptogenic tubers in individuals with tuberous sclerosis complex (TSC) can be challenging. We assessed whether magnetic source imaging (MSI) and coregistration of (18)fluorodeoxyglucose PET (FDG-PET) with MRI could improve the identification of the epileptogenic regions noninvasively in children with TSC. METHODS: In addition to standard presurgical evaluation, 28 children with intractable epilepsy from TSC referred from 2000 to 2007 had MSI and FDG-PET/MRI coregistration without extraoperative intracranial EEG. RESULTS: Based on the concordance of test results, 18 patients with TSC (64%) underwent surgical resection, with the final resection zone confirmed by intraoperative electrocorticography. Twelve patients are seizure free postoperatively (67%), with an average follow-up of 4.1 years. Younger age at surgery and shorter seizure duration were associated with postoperative seizure freedom. Conversely, older age and longer seizure duration were linked with continued seizures postoperatively or prevented surgery because of nonlateralizing or bilateral independent epileptogenic zones. Complete removal of presurgery MSI dipole clusters correlated with postoperative seizure freedom. CONCLUSIONS: Magnetic source imaging and (18)fluorodeoxyglucose PET/MRI coregistration noninvasively localized the epileptogenic zones in many children with intractable epilepsy from tuberous sclerosis complex (TSC), with 67% seizure free postoperatively. Seizure freedom after surgery correlated with younger age and shorter seizure duration. These findings support the concept that early epilepsy surgery is associated with seizure freedom in children with TSC and intractable epilepsy.


Subject(s)
Seizures/etiology , Seizures/pathology , Tuberous Sclerosis/complications , Adolescent , Child , Child, Preschool , Electroencephalography/methods , Female , Fluorodeoxyglucose F18 , Follow-Up Studies , Humans , Infant , Magnetic Resonance Imaging/methods , Male , Neurosurgical Procedures/methods , Positron-Emission Tomography/methods , Radiopharmaceuticals , Retrospective Studies , Seizures/diagnostic imaging , Statistics as Topic , Treatment Outcome , Tuberous Sclerosis/diagnosis , Tuberous Sclerosis/diagnostic imaging , Tuberous Sclerosis/pathology , Tuberous Sclerosis/surgery
2.
J Child Neurol ; 16(9): 661-7, 2001 Sep.
Article in English | MEDLINE | ID: mdl-11575607

ABSTRACT

We retrospectively compared electroencephalographic (EEG) dipoles of interictal spikes from prolonged video-EEG monitoring with magnetoencephalographic dipoles from short-term recording in four children with extratemporal lobe epilepsy. We analyzed both sets of dipoles using individual interictal spikes and single moving dipole modeling and evaluated the profiles of spike appearance, dipole position, and orientation in EEG and magnetoencephalography. We obtained more than 100 magnetoencephalographic spikes in two patients who manifested frequent interictal EEG spikes throughout both day and night but fewer than 40 magnetoencephalographic spikes in two patients who had interictal EEG spikes mainly during sleep. The dipole positions of EEG and magnetoencephalography were in close proximity and included in the surgical resection area. Most of the dipoles between EEG and magnetoencephalography were oriented perpendicularly. A combination of EEG dipole analysis from prolonged video-EEG monitoring and magnetoencephalographic dipole analysis provides complementary information for presurgical evaluation in children with intractable extratemporal lobe epilepsy.


Subject(s)
Electroencephalography , Epilepsies, Partial/diagnosis , Epilepsy, Frontal Lobe/diagnosis , Epilepsy, Temporal Lobe/diagnosis , Magnetoencephalography , Parietal Lobe , Video Recording , Adolescent , Brain Mapping , Child , Diagnosis, Differential , Epilepsies, Partial/physiopathology , Epilepsies, Partial/surgery , Epilepsy, Frontal Lobe/physiopathology , Epilepsy, Frontal Lobe/surgery , Epilepsy, Temporal Lobe/physiopathology , Epilepsy, Temporal Lobe/surgery , Evoked Potentials/physiology , Female , Humans , Length of Stay , Male , Monitoring, Physiologic , Parietal Lobe/physiopathology , Parietal Lobe/surgery , Predictive Value of Tests , Retrospective Studies , Signal Processing, Computer-Assisted
4.
Electroencephalogr Clin Neurophysiol ; 43(2): 151-9, 1977 Aug.
Article in English | MEDLINE | ID: mdl-69526

ABSTRACT

Using clicks with varying interstimulus intervals and coherent tone-bursts, early components of the auditory evoked potential (brain stem responses) were studied in four patients with confirmed acoustic neuroma. Abnormalities in responses appeared with shorter interstimulus intervals and with tone-bursts delivered monaurally to the involved ear; bilateral alterations occurred in one patient with brain stem displacement. The results indicate that BSR can provide a stable, independent, noninvasive measure of auditory nerve function useful in the early detection of acoustic neuroma. The results contribute to the understanding of the so-called human FFR.


Subject(s)
Brain Stem/physiopathology , Electroencephalography , Neurilemmoma/diagnosis , Vestibulocochlear Nerve , Acoustic Stimulation , Adult , Evoked Potentials , Female , Humans , Male , Middle Aged
5.
Neurology ; 25(12): 1101-10, 1975 Dec.
Article in English | MEDLINE | ID: mdl-1238954

ABSTRACT

Serums from six patients with progressive idiopathic acute or chronic polyneuropathy possessed a cytolytic activity against transformed mouse cholinergic or noncholinergic neuroblasts but not against transformed rat astrocytes. This activity was not qualitatively nor quantitatively present in serums from normal controls or from patients with a variety of other motor system disorders and other neurologic disorders. Fluorescein conjugated goat antihuman IgG and IgM monospecific immunoglubulins were used to characterize further the cytotoxic activity from patient serums and these studies suggested the presence of immunoglobulin G (IgG) and immunoglobulin M (IgM) directed against a cell surface neuroblastoma antigen. Cold reactive immunoglobulins of the IgG and IgM type were present in the serums of all six patients. A bioassay is described that may be helpful in evaluating other patients with progressive idiopathic polyneuropathies.


Subject(s)
Cytotoxicity Tests, Immunologic , Immunoglobulin G/analysis , Immunoglobulin M/analysis , Polyneuropathies/immunology , Adolescent , Adult , Aged , Animals , Astrocytoma/immunology , Blood Proteins/analysis , Cells, Cultured , Child , Child, Preschool , Female , Humans , Infant , Male , Mice , Middle Aged , Neuroblastoma/immunology , Peripheral Nerves/pathology , Polyneuropathies/diagnosis , Polyneuropathies/pathology , Species Specificity , Temperature
7.
Dis Nerv Syst ; 35(5): 246-8, 1974 May.
Article in English | MEDLINE | ID: mdl-17894109

ABSTRACT

Forty-one epileptics with normal or nonspecific EEG changes were subjected to methohexital and pentylenetetrazol activations (Group I). Fifteen epileptic patients with specific epileptiform discharges were subjected to methohexital activation procedures (Group II). The present study showed that, though it is a safe agent, methohexital is not an effective electroencephalographic activator for the epileptic population. In this study, it activated only 7% of the epileptics with normal records or minimal and nonspecific EEG abnormalities and it activated only 33.3% of epileptics who had previously demonstrated a specific paroxysmal epileptiform discharge in a routine recording.


Subject(s)
Anesthetics, Intravenous/pharmacology , Electroencephalography , Epilepsy/physiopathology , Methohexital/pharmacology , Adolescent , Adult , Aged , Convulsants/administration & dosage , Convulsants/pharmacology , Epilepsy/diagnosis , Female , Humans , Injections, Intravenous , Male , Middle Aged , Pentylenetetrazole/administration & dosage , Pentylenetetrazole/pharmacology
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