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1.
Afr J Med Med Sci ; 29(2): 123-6, 2000 Jun.
Article in English | MEDLINE | ID: mdl-11379442

ABSTRACT

The relationship between male reproductive function and the blood plasma level of epidermal growth factor (EGF) is of interest in the light of the role that circulating EGF appears to play in regulating mouse spermatogenesis. We measured the concentrations of EGF in the blood plasma of 39 fertile men (sperm count > 20 x 10(6)/ml) and compared them with those of 31 infertile men (sperm < 20 x 10(6)/ml). Blood plasma levels of follicle stimulating hormone (FSH), luiteinising hormone (LH), prolactin and testosterone were also determined. The infertile patients had mean blood plasma EGF concentrations of 0.75 +/- 0.10 ug/L. The value was significantly lower than that of the fertile group (1.28 +/- 0.14 ug/L; P < 0.005). There were statistically significant differences between the fertile and infertile groups in sperm count, sperm viability, mean forward progression, testosterone, LH and FSH (P values between 0.0001 and 0.023). There was no significant difference in the prolactin concentrations between the two groups. Although overall average blood plasma EGF concentrations are significantly lower in the infertile males, regression analysis failed to reveal any direct relationships among the various parameters studied.


Subject(s)
Epidermal Growth Factor/blood , Infertility, Male/blood , Adult , Analysis of Variance , Case-Control Studies , Epidermal Growth Factor/physiology , Follicle Stimulating Hormone/blood , Humans , Luteinizing Hormone/blood , Male , Middle Aged , Prolactin/blood , Regression Analysis , Sperm Count , Sperm Motility , Spermatogenesis/physiology , Testosterone/blood
2.
Am J Reprod Immunol Microbiol ; 7(3): 109-12, 1985 Mar.
Article in English | MEDLINE | ID: mdl-3993828

ABSTRACT

We selected 91 infertile men who were tested for increased sperm-associated immunoglobulin and also tested in the human sperm/hamster ova penetration assay. There was a statistically significant association between the presence of increased sperm-associated IgG alone (p = 0.0218) and both sperm-associated IgG and A (p = 0.0187) when correlated with the failure to penetrate any hamster ova. There was a trend but no statistical significance when sperm-associated immunoglobulin A alone was present. There was a trend but no statistical relationship between the presence of sperm-associated immunoglobulin and the sperm penetration assay when the criteria for normality of the sperm penetration assay was a 15% or greater ovum penetration rate.


Subject(s)
Infertility, Male/immunology , Sperm-Ovum Interactions , Spermatozoa/immunology , Animals , Autoantibodies , Cricetinae , Female , Humans , Male
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