Pitfalls in comparison of coronary artery measurements of Indian population with different geographical area studies.

INTRODUCTION: Coronary artery disease (CAD) is the most common cause of morbidity and mortality especially in the developing countries. Coronary artery measurements (CAM) are the most important factor affecting the procedure and outcome of coronary angioplasty (PCI) as well as coronary by-pass operations (CABG). In this study, we aimed to establish a database for the normal CAM as well as for gender difference among the Indian population using quantitative coronary angiography (QCA) with an objective of assessing normal coronary vessel morphology of patients with normal coronaries. MATERIALS AND METHODS: Four thousand angiograms from patients of Indian origin were studied prospectively after procuring the sanction for the same from the ethical committee of the pre-selected hospitals of four states in India. Informed consents were obtained. Post CABG, post PCI patients and patient being diabetic for ≥5 years were also excluded from the study. RESULTS: Ten segments from right and left coronary arteries were taken for diameter measurements. These coronary diameters were indexed to body surface area (BSA) (mean diameter mm/m2 BSA). Among, 4000 patients, 933(23.3%) [M:F-521:412] had normal coronaries and 3067 (76.7%) were diseased. DISCUSSION AND CONCLUSION: The dimensions of the coronary artery segments of Indians were smaller (in BSA indexed and non-indexed data), compared to studies from other continents which can be due to their smaller BSA.

Binary logistic regression analysis of hard palate dimensions for sexing human crania.

Sex determination is the preliminary step in every forensic investigation and the hard palate assumes significance in cranial sexing in cases involving burns and explosions due to its resistant nature and secluded location. This study analyzes the sexing potential of incisive foramen to posterior nasal spine length, palatine process of maxilla length, horizontal plate of palatine bone length and transverse length between the greater palatine foramina. The study deviates from the conventional method of measuring the maxillo-alveolar length and breadth as the dimensions considered in this study are more heat resistant and useful in situations with damaged alveolar margins. The study involves 50 male and 50 female adult dry skulls of Indian ethnic group. The dimensions measured were statistically analyzed using Student's t test, binary logistic regression and receiver operating characteristic curve. It was observed that the incisive foramen to posterior nasal spine length is a definite sex marker with sex predictability of 87.2%. The palatine process of maxilla length with 66.8% sex predictability and the horizontal plate of palatine bone length with 71.9% sex predictability cannot be relied upon as definite sex markers. The transverse length between the greater palatine foramina is statistically insignificant in sexing crania (P=0.318). Considering a significant overlap of values in both the sexes the palatal dimensions singularly cannot be relied upon for sexing. Nevertheless, considering the high sex predictability of incisive foramen to posterior nasal spine length this dimension can definitely be used to supplement other sexing evidence available to precisely conclude the cranial sex.

Binary Logistic Regression Analysis of Foramen Magnum Dimensions for Sex Determination.

Purpose. The structural integrity of foramen magnum is usually preserved in fire accidents and explosions due to its resistant nature and secluded anatomical position and this study attempts to determine its sexing potential. Methods. The sagittal and transverse diameters and area of foramen magnum of seventy-two skulls (41 male and 31 female) from south Indian population were measured. The analysis was done using Student's t-test, linear correlation, histogram, Q-Q plot, and Binary Logistic Regression (BLR) to obtain a model for sex determination. The predicted probabilities of BLR were analysed using Receiver Operating Characteristic (ROC) curve. Result. BLR analysis and ROC curve revealed that the predictability of the dimensions in sexing the crania was 69.6% for sagittal diameter, 66.4% for transverse diameter, and 70.3% for area of foramen. Conclusion. The sexual dimorphism of foramen magnum dimensions is established. However, due to considerable overlapping of male and female values, it is unwise to singularly rely on the foramen measurements. However, considering the high sex predictability percentage of its dimensions in the present study and the studies preceding it, the foramen measurements can be used to supplement other sexing evidence available so as to precisely ascertain the sex of the skeleton.

The origin of anatomy museums

The following article aims to review the contribution of anatomy museums to the development of anatomical science and to the understanding of human anatomy. We also describe the development of anatomical science since the thirteenth century, when artistic sketches and models were used by anatomists to demonstrate anatomical structures, due to religious and ethical issues preventing cadaveric dissection. These were prevalent at a time when there was a lot of inquisitiveness to know more about human anatomy. The origin of the concept of the anatomy museum and its evolution to contemporary anatomy museums are also discussed

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Enhancement of Hippocampal CA3 Neuronal Dendritic Arborization by Glycyrrhiza glabra root extract Treatment in Wistar Albino Rats.

BACKGROUND: In the traditional system of medicine, the roots and rhizomes of Glycyrrhiza glabra (Gg) (family: Leguminosae) have been in clinical use for centuries. AIM: In the present study, we investigated the role of aqueous extract of root of Gg treatment on the dendritic morphology of hippocampal Cornu Ammonis area three (CA3) neurons, one of the regions concerned with learning and memory, in 1- month- old male Wistar albino rats. MATERIALS AND METHODS: The aqueous extract of root of Gg was administered orally in four doses (75, 150, 225 and 300 mg/kg) for 4 weeks. After the treatment period, all experimental animals were subjected to spatial learning (Morris water maze, Hebb-William's maze and elevated plus maze) tests. At the end of the spatial memory tests, the rats were deeply anesthetized with Pentobarbitone and killed their brains were removed rapidly and fixed in rapid Golgi fixative. Hippocampal CA3 neurons were traced using camera lucida, and dendritic arborization and intersections were quantified. These data were compared to those of age-matched control rats. RESULTS: The aqueous root extract of Gg in the dose of 150 and 225 mg/kg/p.o showed a significant (P < 0.01) enhancement of dendritic arborization (dendritic branching points) and dendritic intersections along the length of both apical and basal dendrites in hippocampal (CA3) pyramidal neurons is comparable to control. CONCLUSION: Based on our results obtained, we conclude that constituents present in aqueous root extract of Gg have neuronal dendritic growth stimulating properties.

Beneficial effect of aqueous root extract of Glycyrrhiza glabra on learning and memory using different behavioral models: An experimental study.

BACKGROUND: In the traditional system of medicine, the roots and rhizomes of Glycyrrhiza glabra (Gg) (family: Leguminosae) have been studied for their ability to improve a variety of health ailments. AIMS: The present study was designed to investigate the beneficial effects of Gg root extract on learning and memory in 1-month-old male Wistar albino rats. Four doses (75, 150, 225, and 300 mg/kg) of aqueous extract of root of Gg was administered orally for six successive weeks. MATERIALS AND METHODS: The aqueous extracts were evaluated for their effect on spatial learning and memory in rats using the elevated plus maze, Hebb-William maze, and Morris water maze tests which served as the exteroceptive behavioral model. Diazepam-induced amnesia served as the interoceptive behavioral model. RESULTS: Results showed that all the doses of aqueous root extract of Gg significantly enhanced the memory; however, in the doses of 150 and 225 mg/kg, it showed a significant (P < 0.01) enhancement in learning and memory. Furthermore, Diazepam-induced amnesia was reversed by the aqueous root extract of Gg (150 and 225 mg/kg, p.o.). CONCLUSION: These findings suggest that the memory enhancement effects of Gg may be mediated by its antioxidant and anti-inflammatory activities. Thus, Gg appears to be a promising drug for improving memory in the management of impaired learning, dementia, Alzheimer's disease, and other neurodegenerative disorders.

Sexual dimorphism of the craniofacial region in a South Indian population.

INTRODUCTION: To the best of our knowledge, the sexually dimorphic characteristics of the craniofacial region among the South Indian population are not available in the current literature. We aimed to determine these characteristics using discriminant function analysis. METHODS: A total of 80 recent skulls (40 male, 40 female) from the Department of Anatomy, Yenepoya Medical College, Yenepoya University, Karnataka, India, were analysed. Ten craniofacial parameters were measured and subjected to univariate and multivariate statistical analyses using the Statistical Package for the Social Sciences version 13.0. RESULTS: Statistical analyses revealed that the differences in the bizygomatic, orbital and biorbital breadths of males and females were significant (p < 0.05). Direct method gave an accuracy of 68.8% for sex determination. In stepwise analysis, bizygomatic breadth and upper facial height were selected, giving a 65.0% accuracy for sex prediction. CONCLUSION: Craniofacial parameters are sexually dimorphic. The present study established several features of craniofacial morphometry that can be used for sex determination among the South Indian population. The findings of the present study serve as a foundation for future studies that aim to compare craniofacial parameters among various ethnic groups in South India.

Primary pattern of arteries of upper limb with relevance to their variations / Patrón primario de las arterias de los miembros superiores con relevancia a sus variaciones

A detailed description of the vascular pattern of upper limbs especially their variations in their origin, course and branching pattern is of utmost importance anatomically in general and clinically in particular. These variations have drawn attention of surgeons, physicians, radiologists and interventionists due to the advanced surgical procedures practiced in vascular surgeries, plastic (reconstructive) surgeries and also for diagnostic and therapeutic approaches. 50 cadavers (100 upper limbs) were used for the study, which were dissected as the part of routine dissection for teaching undergraduate students at our institution. Length of the normal and variant arteries with mean, standard deviation, 'p' and 't' values are noted in each of the limbs. The following variations are observed: i) high division of brachial artery, ii) higher origin of profunda brachii artery, iii) high origin of radial artery, iv) absence of common interosseous artery. The variations are of particular importance to the surgeons operating in the area, especially for those involved in vascular reconstructive surgeries. So it is prudent to do pre-operative studies of the brachial and antebrachial arteries and their branching patterns, to prevent possible complications post operatively.

Una descripción detallada del patrón vascular de los miembros superiores, especialmente sus variaciones en el origen, curso y patrón de ramificación son de suma importancia anatómica en general y clínica en particular. Estas variaciones han llamado la atención de los cirujanos, médicos, radiólogos e intervencionistas debido a los procedimientos quirúrgicos avanzados practicados en cirugía vascular, cirugía plástica (de reconstrucción) y también para los métodos diagnósticos y terapéuticos. 50 cadáveres (100 miembros superiores) se utilizaron para el estudio, los que fueron disecados como parte de una disección de rutina para la enseñanza de los estudiantes de pregrado en nuestra institución. La longitud de las arterias normales y variantes con su media, desviación estándar, valores "p" y "t" se observaron en cada uno de los miembros. Las siguientes variaciones se observaron: i) división alta de la arteria braquial, ii) origen alto de la arteria braquial profunda, iii) origen alto de la arteria radial, iv) ausencia de la arteria interósea común. Las variaciones son de particular importancia para los cirujanos que operan en la zona, especialmente para quienes participan en cirugías de reconstrucción vascular. Por lo tanto, es prudente hacer estudios pre-operatorios de las arterias braquial y antebraquiales y sus patrones de ramificación, para evitar posibles complicaciones post-operatorias.

The mendosal suture of the occipital bone: occurrence in Indian population, embryology and clinical significance.

The occipital bone is ontogenetically and functionally unique when compared to the other bones of the skull in humans and other mammalian cousins. The occipital bone develops from six ossification centers; any defect in the ossification process will give rise to mendosal suture (accessory suture) and conditions like posterior plagiocephaly. There is a paucity of literature regarding the mendosal suture and further more, its report in Indian population is not known. The present study was conducted to find out the occurrence of mendosal suture in the Indian dry skulls. Fifteen specimens (3%) were found to have these sutures out of five hundred (500) skulls examined. Nine (3.1%) samples are of male skulls out of two hundred ninety (290) and six (2.85%) samples are that of female skulls out of two hundred ten (210). The mendosal suture ran close to the superior nuchal line in all specimens and traveled medially from the lambdoidal suture. The length of the sutures ranged from 0.8 cm to 2.6 cm (1.88 cm) on the right side and 1.4 cm to 2.9 cm (1.94 cm) on the left side respectively in male skulls; and 0.7 cm to 2.8 cm (1.55 cm) on the right side and 1 cm to 2.4 cm (1.42 cm) on the left side, respectively, in female skulls. The origin of mendosal suture from the lambdoidal suture was 5.7 cm to -6.3 cm (5.98 cm) from the tip of the mastoid process on the right side and 5.6 to -6.3 cm (6 cm) on the left side, respectively, in male skulls; and 5.4 cm to -5.8 cm (5.58 cm) on the right side and 5.4 cm to -5.6 cm on the left side respectively in female skulls. The occurrence and clinical significance of the present study is discussed.