[Mental and nutritional habits at the beginning of the COVID-19 pandemic: impact, perspectives and recommendations]. / Hábitos de salud mental y nutricional a inicios de la pandemia por COVID-19: impacto, perspectivas y recomendaciones.

Besides the severe impact on the mortality rate in the world, the COVID-19 pandemic demonstrated the importance of having an optimal physical and mental health, since subjects with chronic diseases were the most affected. The aim of this review was to describe the consequences of nutritional and mental health during the beginning of the pandemic. In developing countries, such as Mexico, the prevalence of mental illnesses including depression, anxiety, stress, and suicide increased considerably. In addition, it was found an increase rate of sedentary lifestyles due to the confinement established as a preventive measure to avoid COVID-19 infections. Concerning eating habits, it was reported a decrease in fruits and vegetables consumption and an increase in energy-dense foods, as well as alcohol consumption or smoking, as compensatory measures for mental disorders of anxiety and depression. Based on the information we look up on the impact of COVID-19 on human health, we suggest as prevention measures multidisciplinary care strategies aimed at promoting mental health, diet, and physical activity habits in a comprehensive context. Likewise, information it is highlighted the importance of establishing care and monitoring programs for patients with chronic diseases, because this factor was decisive for mortality after COVID-19 infection.

Además de su impacto en la tasa de mortalidad en el mundo, la pandemia por COVID-19 demostró la importancia de un estado de salud física y mental óptimo, ya que los sujetos con enfermedades crónicas fueron los más afectados. El objetivo de esta revisión fue describir las consecuencias de la salud nutricional y mental durante los inicios de la pandemia. En los países en vías de desarrollo, como México, la prevalencia de enfermedades mentales como la depresión, la ansiedad, el estrés y los suicidios aumentaron. Además, incrementaron las cifras de sedentarismo debido al confinamiento. Con relación a los hábitos de alimentación, diversos autores reportaron una disminución en el consumo de frutas, verduras, y un aumento de alimentos densamente energéticos, así como el consumo de alcohol o tabaquismo como medidas compensatorias en relación con los trastornos mentales de ansiedad y depresión. A partir de la información consultada en torno al impacto de la COVID-19 en la salud humana, se sugieren como medidas de prevención estrategias de atención multidisciplinaria encaminadas a promover hábitos de salud mental, alimentación y actividad física en un contexto integral. De igual forma, destaca la importancia de establecer programas de atención y monitoreo de pacientes con enfermedades crónicas, debido a que este factor fue determinante para la mortalidad tras la infección por COVID-19.

Association of the genetic variants (-794 CATT5-8 and -173 G > C) of macrophage migration inhibitory factor (MIF) with higher soluble levels of MIF and TNFα in women with breast cancer.

BACKGROUND: Functional variants -173 G > C (rs755622) and -794CATT5-8 (rs5844572) MIF gene have been associated with the risk in several types of cancer, as well as with the increase of soluble levels of MIF and TNFα. However, in previous studies contradictory and uncertain results have been presented on the implication of MIF polymorphisms with the association in cancer, specifically in breast cancer (BC). We investigated whether the variants are associated with the susceptibility to develop BC and the soluble levels of MIF and TNFα in women with BC from western Mexico. MATERIALS AND METHODS: A total of 152 women with BC and 182 control subjects (CS) were enrolled in this study. The determination of genotypes -173 G > C and -794 CATT5-8 MIF polymorphisms was performed by PCR-RFLP and PCR, respectively. In addition, the soluble levels of MIF and TNFα in both studied groups were quantified by ELISA and MILLIPLEX assay, respectively. RESULTS: The most frequent allele found in BC was the G (74.3%) and 6 (54%) in the variants -173G > C and -794 CATT5-8 , respectively, without significant differences in both groups. Nevertheless, the women with BC carriers -173*C and -794CATT7 have higher levels of MIF in comparison with CS. An increase of MIF (BC: 11.1 ng/mL vs CS: 5.2 ng/mL, P < .001) and TNFα (BC: 24.9 ng/mL vs CS: 9.9 pg/mL, P < .001) was found. CONCLUSION: The functional variants of MIF are not genetic susceptibility markers for BC. Nevertheless, the alleles -173*C and -794CATT7 are associated with the increase of MIF circulating in women with BC.

Circulating soluble levels of MIF in women with breast cancer in the molecular subtypes: relationship with Th17 cytokine profile.

Breast cancer (BC) is a health problem worldwide; there is evidence that inflammatory cytokines are increased in BC. Macrophage migration inhibitory factor (MIF) has multiple effects on immune cells, inflammation and cancer. Besides, in previous studies, contradictory and uncertain results have been presented on the implication of Th17 cytokine profile in BC. The aim of this study was to evaluate the plasma levels of MIF and the Th17 cytokine profile in BC and their association with their molecular subtypes and clinical stage. A total of 150 women with BC of Ella Binational Breast Cancer Study and 60 healthy women (HW) were evaluated in cross-sectional study. The molecular subtypes were identified by immunohistochemistry. The plasma levels of MIF were quantified by ELISA and Th17 cytokine profile by multiplex system. MIF and IL-17 were significantly increased in BC versus HW (11.1 vs. 5.2 ng/mL and 14.8 pg/mL vs. 2.5 pg/mL p < 0.001, respectively). Our analysis showed that both MIF and IL-17A were associated with increased risk of breast cancer (OR 3.85 CI 95% 1.98-7.50 and OR 4.51 95% 1.83-11.15, respectively), higher in aggressive subtypes Luminal B, HER2 and TN. Likewise, we observed positive correlation between MIF and IL-17A (p < 0.001). In addition, IL-17E was lower in BC versus HW (p <0.001). Likewise, we observed a positive correlation between MIF and IL-17A (p < 0.001). In conclusion, both MIF and IL-17A were associated with high risk for breast cancer and aggressive molecular subtypes.