Subject(s)
Pancreatitis/complications , Stomach Rupture/etiology , Abdominal Pain/diagnostic imaging , Acute Disease , Hematemesis/etiology , Humans , Male , Middle Aged , Pancreatitis/diagnostic imaging , Pancreatitis/surgery , Severity of Illness Index , Stomach Rupture/diagnostic imaging , Stomach Rupture/surgery , Tomography, X-Ray ComputedSubject(s)
Humans , Male , Pancreatitis/complications , Stomach Rupture/etiology , Pancreatitis/surgery , Pancreatitis/diagnostic imaging , Stomach Rupture/surgery , Stomach Rupture/diagnostic imaging , Severity of Illness Index , Tomography, X-Ray Computed , Abdominal Pain/diagnostic imaging , Hematemesis/etiology , Acute DiseaseABSTRACT
La trombosis parcial segmentaria del cuerpo cavernoso (TPSCC) es una patología extremadamente infrecuente, que afecta principalmente a hombres jóvenes, cuya etiología aún no está clara. Se caracteriza por una trombosis del cuerpo cavernoso en su porción proximal, prácticamente siempre unilateral, generando dolor perineal. El caso presentando cuenta con una acabada descripción de los factores de riesgo que se cree asociados a la patología, así como un completo registro imagenológico (AU)
Partial segmental thrombosis of the corpus cavernosum (PSTCC) is an extremely rare disease, mainly affecting younger men, and with an aetiology that is not completely understood. It is characterised by thrombosis of the proximal portion of the corpus cavernosum, almost always unilateral, generating perineal pain. In the current case report, a complete description of the risk factors and imaging associated with this pathology is presented (AU)
Subject(s)
Humans , Male , Adult , Cavernous Sinus Thrombosis/complications , Cavernous Sinus Thrombosis/pathology , Cavernous Sinus Thrombosis , Risk Factors , Tomography, Emission-Computed/instrumentation , Tomography, Emission-Computed/methods , Tomography, Emission-Computed , Perineum/pathology , Perineum , Andrology/methodsABSTRACT
BACKGROUND: The mortality of lung cancer (LC), increases each year in the world, in spite of any advances, in development of new drugs to advance stages of LC. The high incidence of LC has been associated with smoking habit, genetic diversity and environmental pollution. Antofagasta region has been reported to have the highest LC mortality rate in Chile and its inhabitants were exposed to arsenic in their drinking water in concentrations as high as 870 µg/L. Non-invasive techniques such as biomarkers (Automatic Quantitative Cytometry: AQC and DR70) and Auto Fluorescence Bronchoscopy (AFB) might be potentially useful as a supplementary diagnostic approach and early detection. Early detection is one of the most important factors to intervene and prevent cancer progression in LC. This is a work of an ongoing prospective bimodality cancer surveillance study in high risk LC volunteers. Enrolment was done in subjects from Antofagasta and Metropolitan regions. In addition, we enrolled subjects who were suspected of having lung cancer. AQC, DR70 and AFB were used as tools in the detection of pre-neoplastic (PNL) and neoplastic lesions (NL). RESULTS: Half of the samples, classified as suspicious by AFB, were confirmed as metaplasia or dysplasia by histopathology. For LC, DR70 showed a higher sensitivity (95.8%) and specificity (91.9%) than AQC. However, for PNL AQC showed a higher sensitivity (91.9%) than DR70 (27.3%), although both with low PPV values. As a pre screener, both biomarkers might be employed as complementary tools to detect LC, especially as serially combined tests, with a sensitivity of 60% and a PPV of 65.2%. Additionally, the use of parallel combined tests might support the detection of PNL (sensitivity 91.2%; PPV 49.1%). CONCLUSION: This work adds information on cellular and molecular biomarkers to complement imaging techniques for early detection of LC in Latin America that might contribute to formulate policies concerning screening of LC. Supported by INNOVA-CORFO, Chile.
Subject(s)
Adenocarcinoma/pathology , Early Detection of Cancer/methods , Lung Neoplasms/pathology , Precancerous Conditions/pathology , Adenocarcinoma/epidemiology , Adult , Aged , Aged, 80 and over , Bronchoscopy/methods , Carcinoma/epidemiology , Carcinoma/pathology , Chile/epidemiology , Confidence Intervals , Double-Blind Method , Female , Humans , Image Cytometry/standards , Lung Neoplasms/epidemiology , Male , Metaplasia/diagnosis , Middle Aged , Optical Imaging/standards , Predictive Value of Tests , Prevalence , Prospective Studies , ROC Curve , Risk Assessment , Sentinel Surveillance , Small Cell Lung Carcinoma/epidemiology , Small Cell Lung Carcinoma/pathology , Sputum/cytologyABSTRACT
BACKGROUND: The mortality of lung cancer (LC), increases each year in the world, in spite of any advances, in development of new drugs to advance stages of LC. The high incidence of LC has been associated with smoking habit, genetic diversity and environmental pollution. Antofagasta region has been reported to have the highest LC mortality rate in Chile and its inhabitants were exposed to arsenic in their drinking water in concentrations as high as 870 µg/L. Non-invasive techniques such as biomarkers (Automatic Quantitative Cytometry: AQC and DR70) and Auto Fluorescence Bronchoscopy (AFB) might be potentially useful as a supplementary diagnostic approach and early detection. Early detection is one of the most important factors to intervene and prevent cancer progression in LC. This is a work of an ongoing prospective bimodality cancer surveillance study in high risk LC volunteers. Enrolment was done in subjects from Antofagasta and Metropolitan regions. In addition, we enrolled subjects who were suspected of having lung cancer. AQC, DR70 and AFB were used as tools in the detection of pre-neoplastic (PNL) and neoplastic lesions (NL). RESULTS: Half of the samples, classified as suspicious by AFB, were confirmed as metaplasia or dysplasia by histopathology. For LC, DR70 showed a higher sensitivity (95.8%) and specificity (91.9%) than AQC. However, for PNL AQC showed a higher sensitivity (91.9%) than DR70 (27.3%), although both with low PPV values. As a pre screener, both biomarkers might be employed as complementary tools to detect LC, especially as serially combined tests, with a sensitivity of 60% and a PPV of 65.2%. Additionally, the use of parallel combined tests might support the detection of PNL (sensitivity 91.2%; PPV 49.1%). CONCLUSION: This work adds information on cellular and molecular biomarkers to complement imaging techniques for early detection of LC in Latin America that might contribute to formulate policies concerning screening of LC. Supported by INNOVA-CORFO, Chile.