1.
Zh Mikrobiol Epidemiol Immunobiol
; (1): 83-8, 1993.
Article
in Russian
| MEDLINE
| ID: mdl-7520655
ABSTRACT
F. tularensis lipopolysaccharide (LPS) was studied with the use of monoclonal antibodies (McAb) having protective properties. The binding site of these McAb (IgG2a) is localized on the O-chain of LPS. In contrast to LPS isolated from vaccine strain 15, LPS isolated from F. tularensis cells in the R-form has no O-chains and does not interact with McAb.
Subject(s)
Antibodies, Bacterial/analysis , Antibodies, Monoclonal/analysis , Antibody Specificity , Epitopes/analysis , Francisella tularensis/immunology , Lipopolysaccharides/immunology , Animals , Antibodies, Bacterial/isolation & purification , Antibodies, Monoclonal/isolation & purification , Binding Sites, Antibody/immunology , Epitopes/isolation & purification , Francisella tularensis/pathogenicity , Hybridomas/immunology , Immunologic Techniques , Lipopolysaccharides/isolation & purification , Mice , Mice, Inbred BALB C , Serial Passage , Virulence/immunology
2.
Zh Mikrobiol Epidemiol Immunobiol
; (9-10): 67-70, 1992.
Article
in Russian
| MEDLINE
| ID: mdl-1481610
ABSTRACT
The preventive activity of five monoclonal antibodies (McAb) in experimental tularemia was evaluated. McAb produced by hybridoma FB11-k (IgG2a), specific to F. tularensis lipopolysaccharide, prevented the death of mice and guinea pigs infected with F. tularensis virulent strain 503 of the holarctic subspecies.