[Adverse effects of multi-drug therapy in patients with tuberculosis and ways of their correction]. / Negativnye vozdeistviia polikhimioterapii u bol'nykh tuberkulezom i puti ikh korrektsii.

Thirty and seventy six patients with tuberculosis receiving multidrug therapy and 107 healthy persons were examined. There is a high rate (38.5%) of adverse responses to antibiotics, deteriorated baseline vitamin deficiency, PLO-AOA imbalance, poorer liver tests, preserved protein deficiency, and secondary immunodeficiency. The use of Trofosan, an enterosorbent-antioxidant complex, and MRT as pathogenetic drugs corrects the disorders found. With this, the incidence of adverse decreased on the average by 2 times and the efficiency of inpatient treatment increased.

[Immediate and long-term results of the combined treatment of patients with extensive destructive tuberculosis of the lungs]. / Neposredstvennye i otdalennye rezul'taty kompleksnogo lecheniia bol'nykh s rasprostranennym destruktivnym tuberkulezom legkikh.

To increase the treatment efficacy in patients with extended destructive tuberculosis of the lungs, in the background of adequate combined therapy a number of pathogenetic agents such as methyluracil and glucocorticoids, as well as tuberculin or ultrasound were used. 339 patients were examined. In 320 of them the remote results of the treatment were studied. It was shown that the use of the combined pathogenetic therapy promoted a 19% increase in the frequency of recovery and marked improvement with a simultaneous decrease in the number of lethal outcomes. The remote results of the treatment (closing of the destructive cavities in 88.4 per cent of the patients) proved to be better than the immediate ones. The highest effects were stated in the new cases.