ABSTRACT
The aim of the study was to assess correlative risk of progression of inflammatory periodontal lesions, the development of a systemic inflammatory reaction and cardiovascular diseases. The study involved 89 patients with chronic periodontal disease (CPD) of varying degrees. High cardiovascular disease risk was revealed in 8.8% of patients with moderate and 13.3% of patients with severe periodontal disease. It is proved that an additional factor contributing to the pathogenic relationship between periodontal inflammatory changes and the development of cardiovascular disease is systemic inflammatory response with increased hrC-reactive protein >3.4 mg/l and interleukin-6 to11.0±3.4 mg/l. Changes of blood lipid spectrum with a reduction in apolipoprotein A1 were associated with progression and development of the CPD. Correlations of somatic and dental pathology requires dentists and cardiologists joint efforts to modify common risk factors.
Subject(s)
Cardiovascular Diseases/epidemiology , Chronic Periodontitis/epidemiology , Adult , Apolipoprotein A-I/blood , Biomarkers/blood , C-Reactive Protein/analysis , Cardiovascular Diseases/blood , Chronic Periodontitis/blood , Female , Humans , Interleukin-6/blood , Male , Middle Aged , Risk Factors , Russia/epidemiologyABSTRACT
The study included 35 patients (19 men and 16 women, aged 35 to 65 years) with chronic generalized severe periodontitis and atherosclerosis of the brachiocephalic artery (BCA). The changes of the BCA tone were evaluated by ultrasonic duplex scanning before and after transient limb ischemia created by endothelium-dependent vasodilation at baseline and at different laps after the anti-inflammatory and surgical treatment. The size of atherosclerotic plaques before and after the treatment was measured. In the early stages of treatment there were no changes of the tone of the brachial artery. The long-term results after conservative treatment also showed no changes but 6 months after surgical treatment in all patients the study showed the improved of the brachial artery tone on average 3-4% and a slight tendency to decrease of the atherosclerotic plaque.
Subject(s)
Atherosclerosis/diagnostic imaging , Brachial Artery/diagnostic imaging , Chronic Periodontitis/therapy , Endothelium, Vascular/diagnostic imaging , Plaque, Atherosclerotic/diagnostic imaging , Adult , Aged , Atherosclerosis/complications , Atherosclerosis/pathology , Brachial Artery/pathology , Chronic Periodontitis/complications , Chronic Periodontitis/surgery , Endothelium, Vascular/pathology , Female , Humans , Male , Middle Aged , Plaque, Atherosclerotic/pathology , Ultrasonography, Doppler, Duplex , VasodilationABSTRACT
Estimated the relationship between inflammatory periodontal diseases and the risk of developing cardiovascular disease. Installed combined effect of periodontitis and cardiovascular disease.
Subject(s)
Cardiovascular Diseases/epidemiology , Cardiovascular Diseases/microbiology , Periodontitis/epidemiology , Periodontitis/microbiology , Periodontium/microbiology , Carotid Stenosis/epidemiology , Carotid Stenosis/microbiology , Humans , Risk FactorsABSTRACT
The study of gingival microvessels was carried out by means of computer capillaroscopy in patients with moderate periodontal disease and early symptoms of atherosclerosis of extracranial portions of cephalic arteries. The results proved the decreased density of the capillar network in the marginal gingiva, as well as of linear and volumetric blood flow velocities drop in the arterial and venular portions of capillaries in patients with periodontal diseases combined with early atherosclerosis.
Subject(s)
Capillaries/ultrastructure , Cerebral Arterial Diseases/complications , Gingiva/blood supply , Image Processing, Computer-Assisted/methods , Intracranial Arteriosclerosis/complications , Microscopic Angioscopy/methods , Periodontitis/physiopathology , Adult , Female , Hemodynamics , Humans , Male , Microcirculation , Middle Aged , Periodontitis/complicationsABSTRACT
By ultrasonicduplex scanning nature estimated haemodynamics in the arteriessubmentalis and facial of patients with early signs of atherosclerotic changes in the brakhiotsefalarteries and periodontal pathology of different stages - for perfection of prophylaxis of periodontal diseases by the means of investigation of prophylaxis vascular diseases. It was established, that influence of risk factors is more important than the age of patients.