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Rev Med Chir Soc Med Nat Iasi
; 112(3): 848-55, 2008.
Article
in Romanian
| MEDLINE
| ID: mdl-20201280
ABSTRACT
UNLABELLED: The aim of the study was to investigate the stability of some oral liquid formulations containing 1 mg/ml captopril. MATERIAL AND METHOD: The oral solutions were prepared using captopril substance, keeping the formulation as simple as possible to avoid potentially undesirable excipients. Samples were stored for 39 days below 8 degrees C and at 22 +/- 3 degrees C and analysed for physical, chemical and microbiological stability. RESULTS: The formulations with ascorbic acid are stable for seven days either at 8 and 22 degrees C and could be prepared in hospital pharmacy as a more safely alternative to children terapy with tablets powders.