1.
Bioorg Med Chem Lett
; 28(10): 1765-1768, 2018 06 01.
Article
in English
| MEDLINE
| ID: mdl-29678465
ABSTRACT
Simple 2'-OMe-chemical modification in the loop region of the 15mer G-rich DNA sequence GGTTGGTGTGGTTGG is reported. The G-quadruplex structure of this thrombin-binding aptamer (TBA), is stabilized by single modifications (Tâ¯ââ¯2'-OMe-U), depending on the position of the modification. The structural stability also renders significantly increased inhibition of thrombin-induced fibrin polymerization, a process closely associated with blood-clotting.