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1.
Malar J ; 23(1): 80, 2024 Mar 15.
Article in English | MEDLINE | ID: mdl-38491492

ABSTRACT

BACKGROUND: Malaria vector control activities in Sudan rely largely on Long-Lasting Insecticidal Nets (LLINs), Indoor Residual Spray (IRS) and Larval Source Management (LSM). The present study attempted to determine cost effectiveness of inputs and operations of vector control interventions applied in different environmental settings in central and eastern Sudan, as well as their impact. METHODS: The inputs utilized and cost of each vector control activity, operational achievements and impact of the applied malaria vector control activities; IRS, LLINs and LSM were determined for eight sites in Al Gazira state (central Sudan) and Al Gadarif state (eastern Sudan). Operational costs were obtained from data of the National Malaria Control Program in 2017. Impact was measured using entomological indicators for Anopheles mosquitoes. RESULTS: The total cost per person per year was $1.6, $0.85, and $0.32 for IRS, LLINs and LSM, respectively. Coverage of vector control operations was 97%, 95.2% and 25-50% in IRS, LLINs and LSM, respectively. Vectorial capacity of malaria vectors showed statistically significant variations (P < 0.034) and ranged 0.294-0.65 in areas implemented LSM in comparison to 0.097-0.248 in areas applied IRS and LLINs, respectively. Both indoor and outdoor biting Anopheles mosquitoes showed noticeable increase that reached 3-12 folds in areas implemented LSM in comparison to areas implemented IRS and LLINs. Annual malaria prevalence was 13.1-21.1% in areas implemented LSM in comparison to 3.20%, 4.77% in areas implemented IRS and LLINs, respectively. CONCLUSION: IRS and LLINs are cost effective control measures due to adequate inputs and organized process. However, the unit cost of LSM intervention per outcome and subsequently the impact is hugely affected by the low coverage. The very weak support for implementation of LSM which includes inputs resulted in weakness of its process and consequently its impact. Implementation of LSM by local government in urban settings is challenged by many factors the most important are maintenance of adequate stable level of funding, un-adequate number of well trained health workers, unstable political and administrative conditions and weak infrastructure. These challenges are critical for proper implementation of LSM and control of malaria in urban settings in Sudan.


Subject(s)
Anopheles , Insecticide-Treated Bednets , Insecticides , Malaria , Animals , Humans , Mosquito Control/methods , Cost-Effectiveness Analysis , Sudan/epidemiology , Mosquito Vectors , Malaria/epidemiology , Malaria/prevention & control , Insecticides/pharmacology , Larva
2.
Pestic Biochem Physiol ; 185: 105151, 2022 Jul.
Article in English | MEDLINE | ID: mdl-35772840

ABSTRACT

The chemical composition of cypress, lavender, lemon eucalyptus, and tea tree oils has been investigated using gas chromatography/mass spectrometry (GC/MS). These oils were tested for larvicidal activity against Culex pipiens alongside their nanoemulsions (NEs) and conventional emulsifiable concentrates (ECs). Oil-in-water (O/W) NEs preparation was based on a high-energy ultra-sonication technique. The effect of independent variables of preparation on the different outputs was studied using the response surface method to obtain the optimum preparation technique. The droplet sizes of prepared NEs were significantly different (71.67, 104.55, 211.07, and 70.67 for cypress, lavender, lemon eucalyptus, and Tea tree NEs, respectively). The zeta potentials of NEs were recorded to have a high negatively charge (-28.4, -22.2, -23.6, and - 22.3 mV for cypress, lavender, lemon eucalyptus, and tea tree NEs, respectively). The results showed that the tea tree oil has the most significant effect with LC50 = 60.02 and 57.10 mg/L after 24 and 48 h of exposure, respectively. In comparison, cypress oil proved the lowest toxicity with LC50 values of 202.24 and 180.70 mg/L after 24 and 48 h, respectively. However, lavender oil does not show any effect against larvae at tested concentrations. In addition, pure oil exhibited the lowest larvicidal activity. However, the EC of all tested insecticides slightly improved the toxic action against the larvae. While the NEs showed significantly high toxicity compared to the EO and EC. An in vivo assessment of acetylcholine esterase (AChE), adenosine triphosphatase (ATPase), and gamma-aminobutyric acid transaminase (GABA-T) revealed that the NEs exhibited higher activity than the pure oils and ECs. This work describes these oils with potential use against C. pipiens larvae as eco-friendly products.


Subject(s)
Culex , Insecticides , Oils, Volatile , Animals , Insecticides/chemistry , Insecticides/pharmacology , Larva , Oils, Volatile/chemistry , Oils, Volatile/pharmacology , Plant Oils/chemistry , Plant Oils/pharmacology , Tea
3.
J Egypt Public Health Assoc ; 96(1): 21, 2021 Jul 15.
Article in English | MEDLINE | ID: mdl-34264427

ABSTRACT

BACKGROUND: The growing threat of vector-borne diseases and environmental pollution with conventional pesticides has led to the search for nanotechnology applications to prepare alternative products. METHODS: In the current study, four pyrethroid insecticides include alpha-cypermethrin, deltamethrin, lambda-cyhalothrin, and permethrin were incorporated into stable nanoemulsions. The optimization of nanoemulsions is designed based on the active ingredient, solvent, surfactant, sonication time, sonication cycle, and sonication energy by factorial analysis. The nanoscale emulsions' droplet size and morphology were measured by dynamic light scattering (DLS) and transmission electron microscopy (TEM), respectively. The toxicity of nanoemulsions against Culex pipiens larvae was evaluated and compared with the technical and commercial formulations. The in vitro assay of adenosine triphosphatase (ATPase), carboxylesterase (CaE), and glutathione-S-transferase (GST) were also investigated. Furthermore, molecular docking was examined to assess the binding interactions between the tested pyrethroids and the target enzymes. Also, an ecotoxicological assessment of potential effects of the tested products on the freshwater alga Raphidocelis subcapitata was determined according to OECD and EPA methods. The emulsifible concentration (EC50) and NOEC (no observed effect concentration) values were estimated for each insecticide and graded according to the GHS to determine the risk profile in aquatic life. RESULTS: The mean droplet diameter and zeta potential of the prepared pyrethroid nanoemulsions were found to be in the range of 72.00-172.00 nm and - 0.539 to - 15.40 mV, respectively. All insecticides' nanoemulsions showed significantly high toxicity (1.5-2-fold) against C. pipiens larvae compared to the technical and EC. The biochemical activity data proved that all products significantly inhibited ATPase. However, GST and CaE were significantly activated. Docking results proved that the pyrethroids exhibited a higher binding affinity with CaE and GST than ATPase. The docking scores ranged from - 4.33 to - 10.01 kcal/mol. Further, the biosafety studies of the nanopesticides in comparison with the active ingredient and commercial EC were carried out against the freshwater alga R. subcapitata and the mosquitocidal concentration of nanopesticides was found to be non-toxic. CONCLUSION: The mosquitocidal efficacy of nano-pyrethroids formulated in a greener approach could become an alternative to using conventional pesticide application in an environmentally friendly manner.

4.
Environ Sci Pollut Res Int ; 25(31): 30802-30807, 2018 Nov.
Article in English | MEDLINE | ID: mdl-28374203

ABSTRACT

Pesticides occupy a critical position among many chemicals to which man can be exposed; their diffusion into the environment causes killing and damaging of some forms of life. The lack of highly selective pesticide action represents risk both for man and other desirable forms of life present in the environment. The present study was designed to evaluate the relation between exposure to pesticides and disorder on hematological parameters and kidney function of male agricultural workers with the mean age 37.11 ± 9.3. Another 100 unexposed men matched for age, and socioeconomic status were recruited as a control to compare the levels of hemoglobin, hematocrit, red blood cells (RBCs), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and urea and creatinine concentration. The results indicate that there was no significant difference in hemoglobin concentration and hematocrit value among exposed group as compared to control group. However, there was a significant decrease (P < 0.05) in the RBCs count and a highly significant increase (P < 0.01) in MCV among exposed group. There was no significant difference in MCH and MCHC among exposed group. There was a significant increase (P < 0.05) in urea (39.4 ± 22 mg/dl) among exposed group as compared to control (35.7 ± 26.3 mg/dl). Also, there was a highly significant increase (P < 0.01) in creatinine among exposed group (0.953 ± 0.3 mg/dl) as compared to control (0.8 ± 0.2 mg/dl). In conclusion, exposure to pesticides produces a variety of hematological parameter disorders as well as kidney malfunction in human.


Subject(s)
Agriculture/statistics & numerical data , Farmers/statistics & numerical data , Kidney/drug effects , Occupational Exposure/adverse effects , Pesticides/toxicity , Adult , Hematologic Tests , Humans , Kidney Function Tests , Male , Middle Aged
5.
J Trop Med ; 2016: 8540830, 2016.
Article in English | MEDLINE | ID: mdl-27891154

ABSTRACT

Different mixtures of monoterpenes (ketone, alcohol, and alkene) were loaded on paper discs and wax and their knockdown activities were evaluated against Culex pipiens adults. Some individual monoterpenes were also evaluated by residual toxicity technique. Citronella oil as a reference was also loaded separately or in combination with monoterpenes on paper discs and wax. The ketone monoterpenes mixture (camphor, menthone, carvone, and fenchone) on paper discs was the most active (KT50 = 17.20 min) followed by ketone monoterpenes with citronella oil (KT50 = 20.79 min) and citronella oil alone (KT50 = 28.72 min). Wax formulations proved that the ketone and alcohol (geraniol, thymol, and menthol) monoterpenes gave the most activity as knockdown (KT50 = 31.79 and 43.39 min, resp.). Alcohol monoterpenes formulation recorded KT50 = 43.39 min. Residual activity of tested individual monoterpenes reported that the menthol was more toxic than camphor and camphene. Generally, this study suggests that the monoterpenes have the properties, which make them used as eco-friendly compounds in the control programs of Cx. pipiens adult. The use of paper discs is more applicable than wax in the adulticidal formulations.

6.
Res Rep Trop Med ; 7: 23-38, 2016.
Article in English | MEDLINE | ID: mdl-30050337

ABSTRACT

Efficacy of spinosad and malathion loaded in eco-friendly biodegradable formulations was evaluated for controlling Culex pipiens larvae. Malathion (organophosphorus larvicide) and spinosad (naturally derived insecticide) were loaded on chitosan/alginate/gelatin capsules. Capsules were characterized by size measurement, scanning electron microscopy, Fourier transform infrared spectroscopy, and water uptake. In vitro release kinetics of the larvicides was studied in the running and stagnant water. Biochemical studies on the larvae treated with technical and formulated insecticides were also demonstrated. The results indicated that the released spinosad was active for a long time up to 48 and 211 days in the running and stagnant water, respectively. However, the capsules loaded with malathion showed larvicidal activity for 20 and 27 days in the running and stagnant water, respectively. Technical and formulated malathion and spinosad had an inhibition effect on acetylcholinesterase, carboxylesterase, and glutathione S-transferase. The results proved that the prepared capsules consisting of biodegradable polymers containing larvicides could be effective as controlled-release formulation against C. pipiens larvae for a long period.

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