ABSTRACT
OBJECTIVE: To compare the extent of perilimbal conjunctival pigmentation and limbal palisadal pigmentation in patients with vernal conjunctivitis and controls and correlate it with the duration of disease. STUDY DESIGN: Case control study. PLACE AND DURATION OF STUDY: Eye Department, Combined Military Hospital, Abbottabad, from May 2009 to March 2010. METHODOLOGY: One hundred subjects including 50 patients with vernal conjunctivitis and 50 controls were studied. Demographic data, family and personal history, disease duration, symptoms, signs, complications and extent of perilimbal and palisadal conjunctival pigmentation were recorded among patients and controls. Mann Whitney-U test and Spearman's rho test were used for statistical analysis. RESULTS: The extent of perilimbal conjunctival pigmentation in patients with vernal conjunctivitis was more than controls (p < 0.0001). Similarly, limbal palisadal pigmentation was also more extensive than controls (p = 0.004). There was no correlation between the duration of disease and severity of conjunctival pigmentation (r = 0.24) (p = 0.086). CONCLUSION: The presence of increased perilimbal and limbal palisadal conjunctival pigmentation among patients with vernal conjunctivitis is a specific sign of vernal conjunctivitis.
Subject(s)
Conjunctiva/pathology , Conjunctival Diseases/diagnosis , Conjunctivitis, Allergic/diagnosis , Pigmentation Disorders/diagnosis , Adolescent , Child , Child, Preschool , Conjunctival Diseases/etiology , Conjunctivitis, Allergic/complications , Disease Progression , Female , Follow-Up Studies , Humans , Male , Pigmentation Disorders/etiology , Prospective Studies , Severity of Illness IndexABSTRACT
Papulonecrotic tuberculids represent an immunological expression of an internal focus of tuberculosis in an individual with a moderate or high degree of immunity. It responds to anti-tuberculosis treatment and is characterized by an eruption of necrotizing papules occurring in symmetrical crops, particularly affecting the elbows, knees, buttocks and face. A case of papulonecrotic tuberculids associated with immune mediated unilateral uveitis is reported in which all investigations were negative for tuberculosis except a strongly positive tuberculin test. There was an excellent response to anti-tuberculosis treatment. The association of immune mediated uveitis with papulonecrotic tuberculids has not been described before.
