ABSTRACT
As part of our search for new secondary metabolites from Macaranga hurifolia Beille, a phytochemical investigation was carried out on the fruits that led to the isolation and characterization of two new prenylated flavonol derivatives named macafolias A (1) and B (2), along with five known compounds. Their chemical structures were established on the basis of extensive analysis of their 1-D and 2-D NMR (1H, 13C, APT, COSY, HSQC and HMBC) in conjunction with mass spectroscopy and by comparison with data from the literature. The in vitro assay of the antibacterial potency of the crude extract, fractions and some pure compounds were evaluated against a wide range of bacteria strains.
Subject(s)
Euphorbiaceae , Flavonoids , Flavonoids/pharmacology , Flavonoids/chemistry , Fruit/chemistry , Molecular Structure , Euphorbiaceae/chemistry , Anti-Bacterial Agents/pharmacology , Anti-Bacterial Agents/chemistryABSTRACT
This article deals with a phytochemical investigation of Melicia excelsa from which melicilamide A (1), a new ceramide has been isolated. Its structure was determined by comprehensive analyses of its (1)H- and (13)C-NMR, COSY, HMQC and HMBC spectroscopic, EI-MS and ESI-MS data. The remaining one known compound was identified as ß-sitosterol glucopyranoside.
Subject(s)
Ceramides/isolation & purification , Moraceae/chemistry , Plant Extracts/chemistry , Ceramides/chemistry , Glucosides/isolation & purification , Molecular Structure , Nuclear Magnetic Resonance, Biomolecular , Sitosterols/isolation & purification , Spectrum Analysis/methodsABSTRACT
Phytochemical investigation of Hylodendron gabunensis resulted in the isolation of two new glyceride derivatives, hyloglyceride (1) and hylodiglyceride (2). The structures of the two new compounds were determined by comprehensive analysis of their 1D and 2D NMR spectroscopic, and HREIMS data. One known compound was also isolated and identified as beta-sitosterol.
