1.
J Org Chem
; 65(4): 1200-6, 2000 Feb 25.
Article
in English
| MEDLINE
| ID: mdl-10814072
ABSTRACT
Three synthetic routes to 5-substituted 1,3-diazacyclohexane derivatives 1 are reported. The first method involves treatment of 1, 3-diaminopropan-2-ol 2 with paraformaldehyde to yield 5-hydroxy-1, 3-diazacyclohexane 3. A second method is based on the condensation of 2-bromo-2-nitro-1,3-propanediol with tert-butylamine and formaldehyde to yield 1,3-di-tert-butyl-5-bromo-5-nitro-1, 3-diazacyclohexane 22. The third method relies on the cycloalkylation of methylenebisacetamide with 3-chloro-2-chloromethyl-2-propene to provide 5-exomethylene-1, 3-diacetyl-1,3-diazacyclohexane 28. Functional group manipulations of 3, 22, and 28 provide a number of novel 1,3-diazacyclohexanes functionalized at the 5-position.
2.
3.
Anal Chem
; 43(13): 1815-20, 1971 Nov.
Article
in English
| MEDLINE
| ID: mdl-5110872
4.
Anal Chem
; 42(12): 1432-5, 1970 Oct.
Article
in English
| MEDLINE
| ID: mdl-5458227
5.
J Am Chem Soc
; 92(17): 5170-5, 1970 Aug 26.
Article
in English
| MEDLINE
| ID: mdl-5432663
6.
J Am Chem Soc
; 91(13): 3681-2, 1969 Jun 18.
Article
in English
| MEDLINE
| ID: mdl-5784193
7.
Tetrahedron Lett
; (18): 1397-400, 1969 Apr.
Article
in English
| MEDLINE
| ID: mdl-5794434
8.
Tetrahedron Lett
; (6): 401-5, 1969 Feb.
Article
in English
| MEDLINE
| ID: mdl-5794412